Preparation method of phenolic hydroxy autopolymerization hydrogel

Abstract

The invention discloses a preparation method of phenolic hydroxy autopolymerization hydrogel, and belongs to the technical field of a biological material. In the invention, an oxidation-reduction reaction is performed between specific metal ions and organic matter containing phenolic hydroxy to generate quinonyl free radicals, and simultaneously, the quinonyl free radicals and a complex formed with the metal ions and the organic matter containing the phenolic hydroxy synergistically and efficiently catalyze persulfate to generate hydroxyl free radicals; finally, double bonds of a dual-bond compound are opened to polymerize to form a hydrogel network. In the invention, a metal ion-phenolic hydroxy complex catalytic system can carry out autocatalysis by generating the quinonyl free radicalsto generate the hydrogel; different from a conventional chemical crosslinking process, the preparation method enables a crosslinking network to be homogenized, proposes a brand new principle and ideafor polymerization of the hydrogel, does not require addition of a crosslinking agent and an assistant and auxiliary conditions, and is high in gel forming rate and excellent in gel forming effect.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method of phenolic hydroxyl self-polymerized hydrogel. Background technique [0002] Hydrogels have good biocompatibility and water permeability, and hydrogel materials with different microstructures and properties can be obtained through artificial synthesis; these properties make hydrogels widely used in the field of biomedicine; but traditional The double-bond hydrogels have difficulty in double-bond polymerization, which needs to be completed under the action of cross-linking agents, auxiliary agents or auxiliary ultraviolet light. [0003] Secondly, NNNN-tetramethylethylenediamine, an auxiliary agent commonly used in the polymerization of traditional hydrogels such as polyacrylamide, has certain toxicity and pollutes the environment, while the polymerization of polyacrylic acid requires a cross-linking agent, and it must be catalyzed by ultraviolet light. ...

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Problems solved by technology

[0002] Hydrogels have good biocompatibility and water permeability, and hydrogel materials with different microstructures and properties can be obtained through artificial synthesis; these properties make hydrogels widely used in the field of biomedicine; but traditional The double bond hydrogel has difficulty in double bond polymerization, which needs to be completed under the action of crosslinking agent, auxiliary agent or auxiliary ultraviolet light

[0003] Secondly, NNNN-tetramethylethylenediamine, an auxiliary agent commonly used in the polymerization of traditional hydrogels such as polyacrylamide, has certain toxicity and pollutes the environment, while the polymerization of polyacrylic acid requires a cross-linking agent, and it must be catalyzed by ultraviolet light. complete polymerization, etc.; on the one hand, the double bond hydrogel has the problem of difficult polymerization and complicated conditions; on the other hand, there are more or less defects in the preparation process of traditional hydrogel, so that hydrogel cannot meet the current Applications in Biology and Engineering

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