A kind of preparation method of phenolic hydroxyl self-polymerization hydrogel

Abstract

The invention discloses a preparation method of a phenolic hydroxyl self-polymerized hydrogel, which belongs to the technical field of biomaterials; in the invention, specific metal ions and organic substances containing phenolic hydroxyls undergo oxidation-reduction reactions to generate quinone free radicals, which are simultaneously combined with metal ions and organic substances containing phenolic hydroxyl groups. The complex formed by the organic matter of the phenolic hydroxyl group synergistically and efficiently catalyzes persulfate to produce hydroxyl radicals, and finally opens the double bond polymerization of the double bond compound to form a hydrogel network; the metal ion-phenolic hydroxyl complex catalytic system in the present invention can be passed The generation of quinone radicals to self-catalyze the formation of hydrogels is different from the traditional chemical cross-linking process, which makes the cross-linking network uniform, and proposes a new theory and idea for the polymerization of hydrogels, without adding cross-linking agents and additives and Auxiliary conditions, and the gelation rate is high, and the gelation effect is good.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method of phenolic hydroxyl self-polymerized hydrogel. Background technique [0002] Hydrogels have good biocompatibility and water permeability, and hydrogel materials with different microstructures and properties can be obtained through artificial synthesis; these properties make hydrogels widely used in the field of biomedicine; but traditional The double-bond hydrogels have difficulty in double-bond polymerization, which needs to be completed under the action of cross-linking agents, auxiliary agents or auxiliary ultraviolet light. [0003] Secondly, NNNN-tetramethylethylenediamine, an auxiliary agent commonly used in the polymerization of traditional hydrogels such as polyacrylamide, has certain toxicity and pollutes the environment, while the polymerization of polyacrylic acid requires a cross-linking agent, and it must be catalyzed by ultraviolet light. ...

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Problems solved by technology

[0002] Hydrogels have good biocompatibility and water permeability, and hydrogel materials with different microstructures and properties can be obtained through artificial synthesis; these properties make hydrogels widely used in the field of biomedicine; but traditional The double bond hydrogel has difficulty in double bond polymerization, which needs to be completed under the action of crosslinking agent, auxiliary agent or auxiliary ultraviolet light

[0003] Secondly, NNNN-tetramethylethylenediamine, an auxiliary agent commonly used in the polymerization of traditional hydrogels such as polyacrylamide, has certain toxicity and pollutes the environment, while the polymerization of polyacrylic acid requires a cross-linking agent, and it must be catalyzed by ultraviolet light. complete polymerization, etc.; on the one hand, the double bond hydrogel has the problem of difficult polymerization and complicated conditions; on the other hand, there are more or less defects in the preparation process of traditional hydrogel, so that hydrogel cannot meet the current Applications in Biology and Engineering

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