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Sensor and capsule integrated biocompatible micro device

A biocompatible, micro-device technology that is applied in sensors, medical science, and pharmaceutical equipment to achieve small size, ensure accuracy, and reduce damage

Pending Publication Date: 2019-03-19
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, regarding a convenient implantation of the target blood vessel segment, through the real-time monitoring of blood flow pressure during and after the operation, according to the change of blood flow pressure, real-time early warning of thrombus formation is implemented. In the formation stage, through the detection of blood flow pressure, the slow release of antithrombotic drugs is realized, and there is no relevant report on a biocompatible micro-device integrating sensors and drug-loaded capsules to achieve antithrombotic purposes.

Method used

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  • Sensor and capsule integrated biocompatible micro device
  • Sensor and capsule integrated biocompatible micro device
  • Sensor and capsule integrated biocompatible micro device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Please see attached figure 1 , figure 1 It is a schematic diagram of a biocompatible microdevice integrating sensors and drug-carrying capsules of the present invention. A biocompatible microdevice integrating a sensor and a drug-carrying capsule, the biocompatible microdevice includes a pressure sensor 1; the pressure sensor 1 is wrapped by a biocompatible polymer to form an elliptical drug-carrying capsule capsule 2; the upper and lower sides of the front section of the drug-loaded capsule 2 are provided with sensor flexible touch rods 11; the upper and lower sides of the middle part of the drug-loaded capsule 2 are provided with tube wall fixing hooks 21; There are heparin slow-release channels 22 on the upper and lower sides; the head end of the drug-loaded capsule 2 is also provided with a lead wire 23, and the tail end is connected with a circuit lead wire 24; the flexible sensor rod 11 of the sensor is connected with the body of the pressure sensor 1; The above...

Embodiment 2

[0036] Please see attached image 3 , image 3 It is another structural schematic diagram of a biocompatible micro-device integrating a sensor and a drug-carrying capsule of the present invention. This embodiment is basically the same as Embodiment 1, the difference being that the surface of the device in this embodiment, that is, the surface of the drug-loaded bag 2 is provided with a plurality of through holes 25; A through hole 25 can make the antithrombotic drug in the drug-loaded bag 2 release in a wider range after the device receives the pressure of the blood flow, thereby effectively ensuring the therapeutic effect of thrombus.

[0037] A biocompatible micro-device integrating a sensor and a drug-carrying capsule according to the present invention uses a pressure sensor as a piezoresistive pressure sensor, which is small in size and is conducive to real-time monitoring of blood flow pressure by placing it into a blood vessel through surgery or interventional methods ...

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Abstract

The invention relates to a sensor and capsule integrated biocompatible micro device. The sensor and capsule integrated biocompatible micro device is characterized by comprising a pressure sensor, which is wrapped by biocompatible polymer into an oval capsule; the upper side and the lower side of the front section of the capsule are provided with sensor flexible touch rods; the upper side and the lower side of the middle of the capsule are provided with pipe wall fixing hooks; the upper side and the lower side of the rear section of the capsule are provided with heparin slowly releasing channels; the sensor flexible touch rods are connected with a pressure sensor body; the heparin slowly releasing channels are communicated with the capsule. The sensor and capsule integrated biocompatible micro device has the advantages of being convenient to implant in blood vessel, achieving real-time alarming of thrombogenesis by real-time monitoring intraoperative and postoperative blood pressure andaccordingly the blood pressure change, and achieving antithrombotic drug slow releasing by implanting a system in positions where thrombus is prone to shaping and detecting the blood pressure duringthe easy formation period of thrombus, thereby achieving the aim of antithrombotic treatment.

Description

technical field [0001] The invention relates to the technical field of drug-carrying devices, in particular to a biocompatible micro-device integrating sensors and drug-carrying capsules. Background technique [0002] With the aging of the population and the improvement of people's living standards, the incidence of arteriosclerosis obliterans (ASO) is increasing year by year both in western countries and in my country. According to literature reports, the amputation rate of ASO is 15.3%, and the mortality rate is 3.6%, which has a great impact on the quality of life of patients. At present, the treatment methods for severe ASO include traditional surgery and endovascular treatment. However, whether it is traditional surgery or endovascular treatment, the high postoperative complication rate has become the main factor restricting the success of treatment. According to foreign literature reports, after ASO surgical treatment, the incidences of intravascular arterial thrombos...

Claims

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Application Information

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IPC IPC(8): A61B5/0215A61M31/00
CPCA61M31/00A61B5/0215A61B5/6876A61M2210/12A61M2210/005
Inventor 王敏李燕甘树杰汤敬东冯弈雯
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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