Artesunate containing toothpaste composition and preparation method of artesunate containing toothpaste composition

Abstract

The invention discloses an artesunate containing toothpaste composition and a preparation method of the artesunate containing toothpaste composition, the artesunate containing toothpaste composition comprises the following raw materials by weight ratio: water materials: 17-20 parts of sorbitol, 4-8 parts of PEG-600, 0.3-0.45 part of saccharin, 0.6-0.8 part of EDTA-2 sodium, and 20-24 parts of deionized water; oil materials: 0.5-1.2 parts of eugenol, 0.6-0.9 part of menthol, 1.0-3.0 parts of star anise oil, 1.0-2.5 parts of artesunate, and 1-1.5 parts of essence; powder materials: 35-42 parts of calcium hydrophosphate, 2-5 parts of silicon dioxide, 1.0-1.5 parts of sodium carboxymethylcellulose, and 2.4-3.0 parts of lauryl sodium sulfate (K12); the water materials, the oil materials and thepowder materials are respectively mixed evenly, are pumped into a three-in-one paste making machine and are stirred evenly to prepare the artesunate containing toothpaste composition. The artesunatecontaining toothpaste composition gives full play to the bacteriostatic action of the artesunate, so that the diseases of oral lichen planus, dental ulcer and gum diseases are effectively alleviated.

Description

technical field [0001] The invention relates to a toothpaste composition, in particular to a toothpaste composition for improving oral mucosa and gingival tissue inflammation and a preparation method thereof. technical background [0002] Oral lichen planus is common in the inner walls of both sides of the mouth, tongue, lips, gums, palate and other parts. Initially, the affected area presents white linear, dendritic, circular or reticular stripes. Red, erosion. It is often mistaken for ordinary oral ulcers, which delays treatment. In addition, oral lichen planus is not a bacterial infection, but a degeneration of cells that cannot be treated with antibiotics. [0003] In recent years, the incidence of oral lichen planus has been increasing. However, many people do not know much about lichen planus, so that benign can turn into malignant. When leukoplakia forms in the affected area, you should be alert to cancer. [0004] Oral ulcer, commonly known as "oral sore", is a co...

AI Technical Summary

Problems solved by technology

[0009] In the above patents, since artemisinin and artesunate are insoluble in water and alcohol compounds, and artemisinin and artesunate exist in the form of molecules, they can play a role on the diseased oral mucosa. Reasons for making artesunate into injection and oral administration

The presence of artesunate in the form of particles cannot be absorbed by the diseased oral mucosa, so in the preparation process of the above-mentioned prior art, artesunate and artesunate are added to the alcohol solution for treatment, and artemisinin and artesunate are not The artesunate is dissolved, but the artemisinin and artesunate are dispersed in the alcohol solution, that is, the artemisinin and artesunate cannot be dissolved into a transparent liquid, and the artemisinin and artesunate are still in the form of particles The state exists in the alcohol liquid, which is a turbid and precipitated mixed solution. In the toothpaste prepared in this way, artesunate still exists in particles, so artemisinin and artesunate cannot be absorbed by the mucosa of oral lesions. The artemisinin and artesunate in the granular state have negligible permeation effect on the mucosa of oral lesions and cannot play a role in improving the treatment of oral lesions.

[0010] In addition, the above-mentioned patent discloses that artemisinin and artesunate have antibacterial effects, but they also add preservative benzoic acid, so it is reasonable to question whether the antibacterial ability of this patent has its disclosed antibacterial properties

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