Multifunctional cerebral neuron targeting polypeptide and its application in preparing medicine for treating Alzheimer's disease

Abstract

The invention belongs to the technical field of pharmaceutical preparations, and relates to a multifunctional cerebral neuron targeting polypeptide and its application in preparing a medicine for treating Alzheimer's disease. The polypeptide of the present invention comprises a peptide chain X targeting a blood brain barrier and a peptide chain Y targeting neuron, which are connected by a flexiblepeptide chain L at middle, and a structure thereof is X-L-Y or Y-L-X. The polypeptide has greater brain targeting and neuronal targeting than the original single targeting peptide (X or Y), and a nano-delivery system linked to targeting polypeptide is used to deliver more drugs to a central neuron part, which greatly improves the therapeutic effect on Alzheimer's disease; the targeted modification is simpler and controllable, the dosage is reduced, and the economic cost is reduced, which has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a polypeptide targeting brain neurons and its application in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] The prior art discloses that Alzheimer's disease (AD) is the most common type of dementia, and its main clinical manifestations are progressive cognitive dysfunction, memory loss, and personality and behavior changes. According to statistics, with the aging of the population, the incidence of AD is increasing year by year. At present, there are about 47 million AD patients in the world. It is estimated that by 2050, the number of AD patients will reach 130 million. Due to the complex etiology and long course of AD (latency period as long as 10 to 25 years), when the clinical diagnosis is made, the apoptotic neurons in the brain tissue of the patient often fail to regenerate, so far there is still no e...

AI Technical Summary

Problems solved by technology

[0004] In order to solve this problem, our research group constructed a cascade targeting nano-delivery system in the early stage. By simultaneously modifying the bifunctional groups (both polypeptides) targeting the BBB and neurons on the surface of the nano-system, it can improve the peptide / transfer ratio to a certain extent. The amount of gene medicine that penetrates the BBB and enters the central neurons improves the therapeutic effect on AD; however, the delivery system needs to modify two targeting peptides, which has disadvantages such as large dosage, complicated preparation, and insufficient targeting efficiency

Images