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Application of zirconium metal organic framework material to clenbuterol hydrochloride detection and removal

A metal-organic framework and clenbuterol hydrochloride technology, which is applied in the application field of zirconium metal-organic framework materials in the detection and removal of clenbuterol hydrochloride, can solve problems such as expensive, complicated preparation steps or time cost, and achieve functional The effect of strong, rich structure types and good adsorption performance

Active Publication Date: 2019-03-22
北京六角体科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned detection methods involve expensive instruments or complicated preparation steps or time costs, and most importantly, both the confirmatory methods and sensing techniques are only suitable for the analysis of CLB, but not for the removal of CLB

Method used

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  • Application of zirconium metal organic framework material to clenbuterol hydrochloride detection and removal
  • Application of zirconium metal organic framework material to clenbuterol hydrochloride detection and removal
  • Application of zirconium metal organic framework material to clenbuterol hydrochloride detection and removal

Examples

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preparation example Construction

[0038] The zirconium metal organic framework material in the present invention is selected from UiO-66 material, which has excellent adsorption performance. Its preparation method comprises the following steps:

[0039] Dissolve zirconium tetrachloride (0.93g, 4mmol) and 1,4 phthalic acid (1.32g, 8mmol) in a mixed solution of 24mL dimethylformamide and 0.67mL hydrochloric acid, and heat at 200-240°C for 14- After 16 hours, UiO-66 was obtained.

[0040] Preferably, the detection and removal method of clenbuterol hydrochloride comprises the following steps:

[0041] (a) preparing zirconium metal-organic framework material, preparing a suspension of zirconium metal-organic framework material and a standard solution of clenbuterol hydrochloride;

[0042] (b) Titrate the suspension of the zirconium metal-organic framework material with a standard solution of clenbuterol hydrochloride, and detect the change of the fluorescence intensity;

[0043] By gradually adding the standard ...

Embodiment 1

[0064] A detection and removal method of clenbuterol hydrochloride, comprising the following steps:

[0065] (a) Prepare UiO-66, prepare a suspension of UiO-66, take 5 mg of UiO-66 and disperse it in 5 ml of deionized water, and ultrasonically oscillate for 10 minutes to detect the fluorescence signal intensity;

[0066] (b) prepare the standard solution of clenbuterol hydrochloride of 30ppm, the clenbuterol hydrochloride solution that concentration is 30ppm is titrated to the suspension of UiO-66, titrate 20 μ L each time, can obviously observe the increase of fluorescence signal intensity drop, such as Figure 4 shown.

[0067] The preparation method of described UiO-66, comprises the steps:

[0068] Dissolve zirconium tetrachloride (0.93g, 4mmol) and 1,4 phthalic acid (1.32g, 8mmol) in a mixed solution of 24mL dimethylformamide and 0.67mL hydrochloric acid, and heat at 220°C for 14 hours to obtain UiO-66.

Embodiment 2

[0070] A detection and removal method of clenbuterol hydrochloride, comprising the following steps:

[0071] To prepare UiO-66, take 5 mg of UiO-66, add clenbuterol hydrochloride solution with a concentration of 10 ppm, and measure the concentration of clenbuterol hydrochloride solution after shaking and absorbing for 10 hours.

[0072] The preparation method of the UiO-66 is the same as in Example 1.

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Abstract

The invention belongs to the technical field of trace target object detection, and particularly relates to application of a zirconium metal organic framework material to clenbuterol hydrochloride detection and removal. According to a clenbuterol hydrochloride detection and removal method, a solution to be tested is used for titrating suspension of the zirconium metal organic framework material; the fluorescence intensity of the solution is detected; when the fluorescence intensity descends, the condition that the clenbuterol hydrochloride exists in the solution to be detected is shown; meanwhile, the clenbuterol hydrochloride is removed. The used zirconium metal organic framework material has high stability and strong function; the clenbuterol hydrochloride can be fast and sensitively detected; good adsorption performance is realized on the clenbuterol hydrochloride; the clenbuterol hydrochloride in water body environment or animal urine can be well removed.

Description

technical field [0001] The invention relates to the technical field of trace target detection, in particular to the application of a zirconium metal organic framework material in detection and removal of clenbuterol hydrochloride. Background technique [0002] Clenbuterol (CLB) is a synthetic compound with a phenylethanolamine structure, which is widely used in the treatment of asthma, airway stenosis, lung disease and growth promotion in livestock production. However, due to the potentially harmful effects of CLB, very low concentrations of CLB are present in feed, animal products, and the aquatic environment, and methods for its detection and removal are in the process of continuous development. So far, a large number of analytical methods have been used to detect CLB in various sample matrices, such as liquid chromatography, liquid chromatography-tandem mass spectrometry, gas chromatography-mass spectrometry, etc., for the confirmatory determination of CLB. However, comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/64
Inventor 王培龙杨浩森苏晓鸥王瑞国程劼张苏董姝君
Owner 北京六角体科技发展有限公司