Eye drop and preparation method thereof
A technology for eye drops and solutions, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as strong toxic and side effects
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[0014] The present invention provides a kind of preparation method of eye drop, wherein, described preparation method comprises:
[0015] 1) cutting honeysuckle and Houttuynia cordata into sections, drying and grinding to obtain a mixed powder; adding a solvent to the mixed powder prepared above for percolation, collecting the percolated solution and drying to obtain a crude extract M1;
[0016] 2) adding water to the crude extract M1 prepared in step 1), mixing, filtering and drying, collecting the dried powder to obtain the extract M2;
[0017] 3) After adding the extract M2, borneol, ethanol and sodium chloride into the water and mixing, then adding a pH regulator to adjust the pH to 6-7 to prepare eye drops.
[0018] The present invention uses honeysuckle and Houttuynia cordata as main materials, utilizes the heat-clearing and detoxifying effects of honeysuckle and Houttuynia cordata, and at the same time, because honeysuckle is sweet in nature and fragrant in cold air, an...
Embodiment 1
[0031] 1) Dry and grind 10 g of honeysuckle and 5 g of Houttuynia cordata into sections to obtain a mixed powder; add 100 mL of water to the mixed powder prepared above for percolation (the drip rate of water is 50 drops / min), and collect the percolation powder. The final solution was dried at a temperature of 60° C. to obtain a crude extract M1;
[0032] 2) adding water to the crude extract M1 prepared in step 1), mixing, filtering and drying, collecting the dried powder to obtain the extract M2;
[0033] 3) Add 10 parts by weight of extract M2, 1 part by weight of borneol, 3 parts by weight of ethanol, 0.5 parts by weight of sodium chloride, 0.005 parts by weight of benzalkonium chloride and 0.01 parts by weight of cysteine to 80 parts by weight of water and mix Afterwards, citric acid was added therein to adjust the pH to 6.8, and then sterilized by radiation to obtain eye drops A1.
Embodiment 2
[0035] 1) Dry and grind 10 g of honeysuckle and 10 g of Houttuynia cordata into sections to obtain a mixed powder; add 500 mL of water to the mixed powder prepared above for percolation (the dripping rate of water is 100 drops / min), and collect the percolated powder. The final solution was dried at a temperature of 100° C. to obtain a crude extract M1;
[0036] 2) adding water to the crude extract M1 prepared in step 1), mixing, filtering and drying, collecting the dried powder to obtain the extract M2;
[0037] 3) Add 10 parts by weight of extract M2, 2 parts by weight of borneol, 5 parts by weight of ethanol, 3 parts by weight of sodium chloride, 0.005 parts by weight of benzalkonium chloride and 0.01 parts by weight of cysteine into 150 parts by weight of water and mix Afterwards, citric acid was added therein to adjust the pH to 6.8, and then sterilized by radiation to obtain eye drops A2.
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