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Preparation method of modified bilirubin adsorbent

An adsorbent and bilirubin technology, which is applied in the field of biomedicine, can solve the problems of reducing the adsorption rate of adsorbents to bilirubin, blocking the effective pore size, and affecting the removal effect of bilirubin, so as to improve blood compatibility and increase The effect of adsorption capacity

Inactive Publication Date: 2019-03-26
重庆希尔康血液净化器材研发有限公司
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  • Application Information

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Problems solved by technology

However, the coating process will block some effective pore sizes of the adsorption resin and reduce the adsorption rate of the adsorbent to bilirubin
In addition, due to the lipophilicity of bilirubin, the PHEMA film is hydrophilic, which is not conducive to the diffusion of bilirubin into the adsorbent, further affecting the scavenging effect on bilirubin

Method used

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  • Preparation method of modified bilirubin adsorbent
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Experimental program
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Effect test

Embodiment 1

[0024] Synthesis of poly(HEMA-co-GMA) copolymer compounds: purified polymer monomers and initiators, according to hydroxyethyl methacrylate (HEMA): glycidyl methacrylate (GMA): N, N- Add dimethylformamide: azobisisobutyronitrile (AIBN) at a mass ratio of 25:5:70:0.3 into a three-necked flask, and stir for 8 hours in a water bath at 70°C under nitrogen protection.

Embodiment 2

[0026] Purification of poly(HEMA-co-GMA) copolymer compound: the polymerization solution was added to 2 times the volume of anhydrous ether to precipitate the polymer, then washed with a large amount of anhydrous ether, and finally dried. That is, a pure poly(HEMA-co-GMA) copolymer compound is obtained.

Embodiment 3

[0028] Preparation of poly(HEMA-co-GMA) coated bilirubin adsorbent: Weigh 1.5g of poly(HEMA-co-GMA) copolymer compound, add 150ml of absolute ethanol, and configure the mass concentration to be 1% (g / mL ) of the coating solution. Add 100ml of fully dried bilirubin adsorbent into the coating solution, stir well, and let stand for 30min. where V 吸附剂 :V 包膜溶液 =1:1.5 Subsequently, the excess coating fluid was removed by suction filtration, and the solid adsorbent was fully dried in a blast drying oven.

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Abstract

The invention provides a preparation method of a modified bilirubin adsorbent. According to the preparation method, a poly(HEMA-co-GMA)-PEI film-coated modified bilirubin adsorbent is obtained. The preparation method comprises the steps of with the bilirubin adsorbent for blood perfusion as a raw material, carrying out physical film coating treatment on the bilirubin adsorbent by virtue of a hydroxyethyl methylacrylate and glycidyl methacrylate copolymer (poly(HEMA-co-GMA)), processing film-coated bilirubin adsorbed resin by virtue of a polyethyleneimine (PEI) solution to graft amino to the poly(HEMA-co-GMA) film, so as to obtain the modified bilirubin adsorbent. According to the modified bilirubin adsorbent, the problem that micro-particles of an adsorbent fall during the blood perfusionis solved, the blood compatibility is improved, and the adsorption capacity of bilirubin is improved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of a modified bilirubin adsorbent. Background technique [0002] Bilirubin is mainly a metabolite of heme in aging red blood cells, and bilirubin at physiological concentrations has antioxidant effects. If the bilirubin is produced too much or the metabolic pathway is blocked, it will lead to the accumulation of a large amount of bilirubin in the body, causing irreversible damage to the human brain and nerves, and even life-threatening in severe cases. In particular, the toxicity of unconjugated free bilirubin is particularly evident. [0003] Hemoperfusion is a common method for the clinical treatment of hyperbilirubinosis, that is, the patient's blood is introduced into a perfusion device that can absorb bilirubin to remove excess bilirubin in the blood, and the purified blood is returned to the body a method of treatment. Adsorbents used for bilirubin hemoper...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30C08F220/28C08F220/32
CPCB01J20/265C08F220/28C08F220/32C08F220/281C08F220/325
Inventor 邹玲玲罗章凯张文
Owner 重庆希尔康血液净化器材研发有限公司
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