Black phosphorus microvesicle pharmaceutical carrier capable of realizing local fixedpoint radiotherapy for tumors and preparation method of black phosphorus microvesicle pharmaceutical carrier
A radiation therapy and radiopharmaceutical technology, applied in the field of black phosphorus microbubble drug carrier and its preparation, can solve the problems of difficult fixed-point enrichment therapy, low dose of radiopharmaceuticals, poor loading, etc., to achieve easy access to lesions and increase enrichment , technical solutions and technical effects with clear results
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specific Embodiment approach 1
[0024] Drug loading step, put through FMoc-NH-PEG12-CH 2 CH 2 COOH-modified black phosphorus aqueous solution injected into medical 99m TcN-NOET ampoule and mix evenly, and then draw out the uniformly dispersed mixed solution, wherein the black phosphorus in the black phosphorus aqueous solution is single-layer and / or few-layer nano black phosphorus flakes, and the particle size is between 500 nanometers and 5 microns between;
[0025] In the microbubble film forming step, inject the mixed solution formed in the drug loading step into the SonoVue microbubble preparation ampoule and fill it with SF 6 Gas, using ultrasonic oscillation and mechanical stirring and shearing successively to vibrate and stir and shear until foaming, and a gray-black dispersed emulsion is obtained. The microbubble concentration in the dispersed emulsion is about 3.0×10 9 pieces / ml. The particle size of the microbubbles in the emulsion is between 2 microns and 5 microns, and the microbubbles are co...
specific Embodiment approach 2
[0026] In the drug loading step, the aqueous solution of black phosphorus modified by fluorescent covalent injection is injected into the medical 99m TcN-NOET ampoule and mix evenly, then draw out the uniformly dispersed mixed solution, wherein the black phosphorus in the black phosphorus aqueous solution is single-layer and / or few-layer nano black phosphorus flakes, the particle size is between 200 nanometers and 4 microns between;
[0027] In the microbubble film-forming step, the mixed solution formed in the drug loading step is injected into the ampoule prepared by mixing phospholipid microbubbles, filled with perfluoropropane gas, and successively adopts ultrasonic oscillation and mechanical stirring and shearing to vibrate and stir until Bubbles, to obtain a gray-black dispersion emulsion, the microbubble concentration in the dispersion emulsion is about 3.2 × 10 9 pieces / ml. The diameter of the microbubbles in the emulsion is between 2 microns and 4 microns, and the i...
specific Embodiment approach 3
[0028] In the drug loading step, the black phosphorus aqueous solution modified by polydopamine is injected into the medical 99m TcN-NOET ampoule and mix evenly, then draw out the uniformly dispersed mixed solution, wherein the black phosphorus in the black phosphorus aqueous solution is single-layer and / or few-layer nano black phosphorus flakes, the particle size is between 200 nanometers and 5 microns between;
[0029] In the microbubble film forming step, inject the mixed solution formed in the drug loading step into the SonoVue microbubble preparation ampoule and fill it with SF 6Gas, using ultrasonic oscillation and mechanical stirring and shearing successively to vibrate and stir and shear until foaming, and a gray-black dispersed emulsion is obtained. The microbubble concentration in the dispersed emulsion is about 3.3×10 9 pieces / ml. The particle size of the microbubbles in the emulsion is between 2 microns and 5 microns, and the microbubbles are coated with SF 6 ga...
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