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Detection method of prototype components and metabolite components in the extract

A detection method and extract technology, which is applied in the field of detection of prototype components and metabolic components in the extract of Baiji, can solve the problems that restrict the deep development of Baiji products, and the substances and mechanism of Baiji's hemostatic effect are unclear. The effect of high repeatability, high throughput, and high ion transmission efficiency

Active Publication Date: 2022-02-18
GUIZHOU MEDICAL UNIV
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Problems solved by technology

However, in addition to the proven hemostatic effect of Baiji polysaccharides in existing studies, the other substances and mechanism of action of Baiji hemostatic are still unclear, especially the research on the direct action substances of Baiji is still blank, which seriously restricts Baiji products. in-depth development of

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  • Detection method of prototype components and metabolite components in the extract
  • Detection method of prototype components and metabolite components in the extract
  • Detection method of prototype components and metabolite components in the extract

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Embodiment Construction

[0021] The specific embodiments of the present invention will be further described below in conjunction with the accompanying drawings. It should be noted here that the descriptions of these embodiments are used to help understand the present invention, but are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not constitute a conflict with each other. The numerical values ​​or numerical ratios involved in the following content refer to mass numerical values ​​or mass ratios unless otherwise specified.

[0022] 1. Materials

[0023] 1.1 Reagent

[0024] Militarine reference substance (batch number: PS180413-03, content ≥ 98%) was purchased from Chengdu Pusi Biotechnology Co., Ltd.; gastrodin reference substance (batch number: 110807-201608, content 97.6%) was purchased from China Institute for Food and Drug Control; α ...

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Abstract

The invention discloses a method for detecting prototype components and metabolic components in an extract of Radix Sinensis. The method comprises: collecting biological samples of serum, urine, feces, and bile after oral administration of the extract of Radix Sinensis to rats, and adopting ultra-high performance liquid phase Chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS) technology detection and metabolic software analysis to determine the prototype components and metabolic components in rats after oral administration of white and extracts, and to clarify white and extracts The main forms of existence of chemical components in the body provide a reference for the development and quality control of white and innovative drugs.

Description

technical field [0001] The invention relates to the field of drug analysis, in particular to a method for detecting prototype components and metabolic components in white root extracts. Background technique [0002] Oral medication is the main method of traditional Chinese medicine treatment. Modern research has confirmed that oral medication enters the blood circulation system through the epithelial cells of the gastrointestinal tract and is distributed to various tissues and organs or targets, and can only produce curative effect when a certain blood concentration is reached. In actual research work, many traditional Chinese medicines and their compound prescriptions have no prototype drug components detected in the blood, but the drug effect is still very significant. It is speculated that the metabolic components produced after the drug is biotransformed in the body play a therapeutic role. It can be seen that the in vivo metabolism research of traditional Chinese medici...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/027
Inventor 黄勇李勇军郑林潘洁巩仔鹏李月婷孙慧园杨畅陆苑刘亭马雪刘春花
Owner GUIZHOU MEDICAL UNIV
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