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Preparation method of polypropylene/polydopamine compounded patch, compounded patch and application

A polydopamine and polypropylene technology, applied in the field of medical materials and their preparation, can solve problems such as easy displacement, and achieve the effects of simple production process, increased abdominal wall tension, and stable properties

Active Publication Date: 2019-04-05
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both sides of the obtained composite patch are coated with polydopamine, that is, both sides of the obtained composite patch have anti-adhesion properties, and there is a risk of easy displacement, and there are still certain problems in clinical practice.

Method used

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  • Preparation method of polypropylene/polydopamine compounded patch, compounded patch and application
  • Preparation method of polypropylene/polydopamine compounded patch, compounded patch and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A polypropylene / polydopamine composite patch, which is a single-layer double-sided structure, one side is a polypropylene mesh surface, and the other side is a polypropylene / polydopamine film surface, that is, the other side is coated on the polypropylene mesh surface. Polydopamine film, its preparation process is as follows:

[0035] Step S1: Prepare 50mL of a 10mmol / L Tris solution, then add 0.12g of dopamine hydrochloride to prepare dopamine hydrochloride with a solubility of 2.4g / L, and add a piece of 2.5cm×2.5cm polypropylene mesh to the above solution The sheet was stirred and reacted in an air atmosphere at 28°C for 24 hours, then taken out, rinsed with distilled water and dried to obtain a polypropylene / polydopamine composite mesh material;

[0036] Step S2: adding sodium chloride into distilled water, continuously adding until it is configured as a saturated saline solution, and then, according to the volume of the saturated saline solution, adding sodium hypoc...

Embodiment 2

[0039] A polypropylene / polydopamine composite patch, which is a single-layer double-sided structure, one side is a polypropylene mesh surface, and the other side is a polypropylene / polydopamine film surface, that is, the other side is coated on the polypropylene mesh surface. Polydopamine film, its preparation process is as follows:

[0040] Step S1: Prepare 50mL of a 10mmol / L Tris solution, then add 0.12g of dopamine hydrochloride to prepare dopamine hydrochloride with a solubility of 2.4g / L, and add a piece of 2.5cm×2.5cm polypropylene mesh to the above solution The sheet was stirred and reacted in an air atmosphere at 28°C for 24 hours, then taken out, rinsed with distilled water and dried to obtain a polypropylene / polydopamine composite mesh material;

[0041] Step S2: adding sodium chloride into distilled water, and continuously adding until it is configured into a saturated saline solution, and then, according to the volume of the saturated saline solution, adding sodium...

Embodiment 3

[0044] A polypropylene / polydopamine composite patch, which is a single-layer double-sided structure, one side is a polypropylene mesh surface, and the other side is a polypropylene / polydopamine film surface, that is, the other side is coated on the polypropylene mesh surface. Polydopamine film, its preparation process is as follows:

[0045] Step S1: Prepare 50mL of a 10mmol / L Tris solution, then add 0.12g of dopamine hydrochloride to prepare dopamine hydrochloride with a solubility of 2.4g / L, and add a piece of 2.5cm×2.5cm polypropylene mesh to the above solution The sheet was stirred and reacted in an air atmosphere at 28°C for 24 hours, then taken out, rinsed with distilled water and dried to obtain a polypropylene / polydopamine composite mesh material;

[0046] Step S2: adding sodium chloride into distilled water, and continuously adding until it is configured as a saturated saline solution, and then, according to the volume of the saturated saline solution, sodium hypochlo...

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Abstract

The invention discloses a preparation method of a polypropylene / polydopamine compounded patch, the compounded patch and application. According to the preparation method disclosed by the invention, a single-layer compounded patch is divided into two faces from a nano scale by using the principle that a polydopamine membrane can be rapidly taken off from polypropylene by using sodium hypochlorite and the concentration of a polypropylene patch is lower than that of a saturated brine solution; a polypropylene / polydopamine membrane face serves as one face, and thus, the compounded patch is effectively prevented from being adhered to organs in an abdominal cavity; a polypropylene face, exposed after a polydopamine nano-membrane falls off, serves as the other face, the face is in contact with theinterior of an abdominal membrane, the tension of an abdominal wall is improved, the risk of displacement can be reduced, the structure is more reasonable, and intraperitoneal requirements and intraperitoneal requirements can be simultaneously met. Simultaneously, by the preparation method, stacked lamination of a variety of composite materials is not involved, the thickness of the polypropylene / polydopamine compounded patch keeps that of a pure PP patch macroscopically, and thus, the patch is relatively lightweight and thin and has a great clinical application value.

Description

technical field [0001] The invention relates to the technical field of medical materials and their preparation. Specifically, the invention relates to a polypropylene / polydopamine composite patch and its preparation method and application. Background technique [0002] Since the patch material was used in hernia repair, the recurrence rate of abdominal wall hernia decreased significantly, and the incidence of postoperative chronic pain also decreased. The patch used for intraperitoneal repair should meet the requirements of two sides, one side has an adhesion effect, and it fits closely with the peritoneum to reduce the risk of displacement; the other side has an anti-adhesion effect, which does not adhere to the organs in the abdominal cavity and reduces risk of intestinal obstruction and intestinal fistula. However, at present, most of the intra-abdominal meshes used clinically rely on imports, which are expensive and complicated to manufacture, and almost all double-side...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/50
CPCA61L27/48A61L27/50C08L25/02C08L79/02
Inventor 林燕欢王辉吴丁财胡民辉黄榕康周铭洪过文泰杨梓锋秦秀森钟清华罗坚初丽丽叶新梅郭学峰吴小剑兰平汪建平
Owner SUN YAT SEN UNIV
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