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Kit for detecting juvenile osteoporosis based on rs7532173

A technology of osteoporosis and kit, applied in the field of genetic diagnosis, can solve the problems that cannot be popularized and used in a large area, and achieve the effect of improving detection accuracy, high specificity, and good accuracy

Inactive Publication Date: 2019-04-12
刘露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the need for special instruments, this method cannot be widely used in some poor areas.

Method used

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  • Kit for detecting juvenile osteoporosis based on rs7532173

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Embodiment 1

[0020] Example 1 Obtaining of SNP molecular markers

[0021] 1. Selection of samples

[0022] The samples used for the SNP molecular marker analysis of this patent come from two large-scale genome-wide association studies (GWAS) of bone density: 1) UK Biobank dataset (UK Biobank, UKB). The sample size of this data set is as high as 142,487 individuals, and each individual has measured heel bone mineral density using quantitative ultrasound technology, while using high-throughput genotyping technology to obtain genotype sequences of genomic SNPs, and using sequences of large-scale reference samples Genotype imputation is performed on the untyped SNP genotype sequence of the data, so as to obtain the genotype information of all SNPs on the genome. The original study of UKB analyzed the genetic association between each SNP and bone density, and published the analysis results on the Internet, the download URL is (http: / / www.gefos.org); 2) International Federation of Osteoporosis ...

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Abstract

The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs7532173. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs7532173, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs7532173 closely related to the genetic susceptibility to the juvenile osteoporosis.

Description

technical field [0001] The invention belongs to the field of gene diagnosis and relates to a kit for juvenile osteoporosis detection. Background technique [0002] Osteoporosis is a systemic skeletal disease characterized by decreased bone mineral content and microstructural deterioration of bone tissue. Its main hazard is the induction of osteoporotic fractures, which significantly reduce the quality of life and survival rate of patients. According to reports, only the osteoporotic fracture of the hip joint has a mortality rate of 20% within 1 year, and about 25% of those who survive for more than 1 year lose their ability to move, which is a serious hazard. [0003] Osteoporosis and fractures mainly occur in middle-aged and elderly people, especially postmenopausal women. With the aging of my country's population, the incidence of osteoporosis has jumped to the third place among common chronic diseases. Currently, there are as many as 90 million osteoporosis patients in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 刘露
Owner 刘露
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