Degradable metal guided tissue regeneration barrier membrane and preparation method thereof

Abstract

The invention discloses a degradable metal guided tissue regeneration barrier membrane and a preparation method thereof. A transparent liquid medium which does not react with metal is used as a protective solution, and especially when a sodium hydroxide solution is adopted, it is achieved that pure magnesium and magnesium alloy materials are processed in water. By using a flowing liquid membrane,the heat diffusion situation on the periphery of a processing site can be obviously improved, and self cleaning in the processing process is achieved. On the basis that the processing quality of the micro-nano structure of the metal surface is ensured, the processing precision is obviously improved, the processing precision reaches about 10 micrometers, and it is of great significance for loadingof a specific drug, such as a drug of a specified size. The content of oxides in the processing product can be remarkably reduced, the adverse effects of excessive oxides on drug loading are avoided,and the degradability and the mechanical property of the metal guided tissue regeneration membrane are ensured. Through the multi-level mesh hole structure of micro-nano patterns, level-by-level release of the drug is achieved; compared with the prior art that deep holes are directly dug in the surface of magnesium alloy to load the drug, the medical treatment effects of treating inflammation andguiding tissue regeneration are greatly improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of oral medical materials, and in particular relates to a degradable metal-guided tissue regeneration barrier film used in oral restoration work and a preparation method thereof. Background technique [0002] With the improvement of living standards, people pay more and more attention to oral health, and periodontal disease is one of the most common oral diseases. The main goal of periodontal treatment is to restore the periodontal ligament and cementum lost due to periodontal disease. In order to achieve this goal, it is often necessary to implant dental implant materials and purposefully guide their own tissue regeneration, which requires fixing a regeneration space that is not disturbed by other tissues. The specific method is to place a layer of film on the periodontal defect and the corroded tooth root surface to prevent other cells from entering, so that periodontal ligament cells and b...

AI Technical Summary

Problems solved by technology

Excessive oxides generated by laser ablation will have adverse effects on drug loading. In addition, the generation of excessive oxides will greatly slow down the degradation rate of materials, even block the degradation process, and change the mechanical properties of metals, which may Abnormal inflammatory response or even abnormalities in cell metabolism, division and differentiation caused by cell attachment or other mechanical stimuli will affect the course of treatment and may lead to the development of fibrosis in some exposed cells

However, when filled with an inert atmosphere or other gases, it is difficult to find a transparent medium that is resistant to femtosecond laser or has no pulse width broadening as a barrier, and the processing conditions are more demanding, which significantly increases the processing cost.

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