Multi-beam optical coherence elasticity measuring system and method based on microlens array

Abstract

The invention provides a multi-beam optical coherence elasticity measurement system and method based on a microlens array, wherein a cornea positioning subsystem is adopted to position an excitation and measurement position of a cornea, the cornea excitation subsystem is adopted to enable the cornea to generate trace mechanical waves and deformation, high-precision detection of the mechanical waves and deformation of each sampling point is carried out through an OCT detection subsystem, so that the rapid measurement of corneal elastic parameters is achieved. The OCT detection subsystem comprises a wide spectrum light source, a first optical fiber coupler, a second optical fiber coupler group, a sample arm, a reference arm group and a spectrum detector group, wherein each light path of thesample arm is provided with a collimating lens and a cylindrical lens which are mutually matched, each light path is also provided with a microlens array at a position in front of the cornea. According to the invention, the microarray lens is adopted as a key optical element, and elastic response of multiple directions and multiple positions around a sample excitation point under single load excitation can be measured simultaneously without adopting a vibrating mirror scanning mode like a prior OCE or a rotating sample arm.

Description

technical field [0001] The patent of the present invention relates to the field of biomedical elastography, in particular to a microlens array-based multi-beam optical coherent in vivo corneal elastometric measurement system and method. Background technique [0002] The human cornea is the main refractive medium of the human eye. The elastic mechanical characteristics of the cornea play an important role in maintaining the normal structure and function of the cornea, and are an important basis for studying the physiological and pathological characteristics of the cornea. Corneal diseases (such as keratoconus, corneal ectasia) and corneal surgery (corneal refractive surgery, ultraviolet cross-linking CXL, etc.) can cause changes in the elastic mechanical properties of the cornea. Conventional clinical detection methods are used for diagnosis based on corneal morphology (topography, thickness, curvature, etc.) and intraocular pressure parameters; although the detection rate of...

AI Technical Summary

Problems solved by technology

However, frequency-swept OCT still has a large phase error, and additional phase stabilization technology is required to obtain a stable phase

In addition, high-speed frequency-scanning OCT is expensive, and it is difficult to promote it clinically.

[0006] (2) The OCE scheme using line field (Line field) scanning (Liu etc. Biomedical OpticsExpress 7(8), 3021-3031(2016).) Although it can increase the detection speed of mechanical waves, it requires stronger light Strong signal, has not yet been successfully applied to the measurement of the human cornea

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