Method for preparing polysaccharide modified nanometer selenium on large scale and application

A large-scale preparation, nano-selenium technology, applied in the field of selenium resource utilization, can solve the problems of environmental pollution, complicated process, high cost of nano-selenium, etc., and achieve the effect of reducing cost

Active Publication Date: 2019-04-19
GUANGDONG JINAN ESTABLISHED SELENIUM SOURCE NANO TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the existing nano-selenium technology has the following disadvantages: 1. The current patents for nano-selenium synthesis are all small-scale synthesis, which cannot be industrialized

Method used

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  • Method for preparing polysaccharide modified nanometer selenium on large scale and application
  • Method for preparing polysaccharide modified nanometer selenium on large scale and application
  • Method for preparing polysaccharide modified nanometer selenium on large scale and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]In 500 liters of reactors, the lentinan (Shaanxi Senfu Natural Products Co., Ltd., 1kg / bag 50%, CAS No. 37339-90-5) aqueous solution and 100L concentration of 10g / L lentinan (Shaanxi Senfu Natural Products Co., Ltd., CAS No. 37339-90-5) and 100L concentration are mixed in the 80mM Vc aqueous solution uniform. Then pump the mixed solution into a 500L fermenter, add water to 450L, start the fermenter, maintain the stirring speed at 90 rpm and stir for 5min, and continue to mix the lentinan aqueous solution and the Vc aqueous solution. Then slowly add 30 L of sodium selenite aqueous solution containing 700 g with a low-pressure water pump. Close the fermenter, set the number of revolutions to 70 revolutions / min, and react for 8 hours under the conditions of a pressure of 0.1 MPa and a reaction temperature of 50°C. After the reaction is completed, the prepared lentinan-modified nano-water selenium solution is exported through the outlet of the fermenter and placed in a clea...

Embodiment 2

[0049] In a 25 ml reactor, nano-selenium was prepared with chitosan (Sinopharm Chemical Reagent Co., Ltd., biochemical reagent, batch number 20160525, 100 g / bottle) as a modifier. First, mix 0.05g chitosan with 5mL 80mM Vc aqueous solution, add 0.2mL 1% (v / v) acetic acid to dissolve, then add 5mL water, and stir for 5min at 90 rpm. Then add 5 mL of sodium selenite aqueous solution with a concentration of 23.3 g / L, set the rotation speed to 70 rpm, and react for 8 hours under the conditions of 0.1 MPa and 50° C., and the obtained solution is a transparent orange solution. Finally, the chitosan-modified nano-selenium aqueous solution is filtered through a filter membrane (molecular weight cut-off: 10KD) to obtain the purified chitosan-modified nano-selenium aqueous solution, which is orange in appearance and stored at 4°C.

[0050] After the obtained orange solution was placed for 120 hours, a large amount of gray-red flocculent precipitates appeared, which could not be disperse...

Embodiment 3

[0052] In a 25 ml reactor, carboxymethyl chitosan (substitution degree greater than 80%, Mackin) was used to replace the acid-soluble chitosan in Example 2 to prepare nano-selenium. First, mix 0.05 g of carboxymethyl chitosan with 5 mL of 80 mM Vc aqueous solution, then add 5 mL of water, and stir at 90 rpm for 5 min. Then add 5 mL of sodium selenite aqueous solution with a concentration of 23.3 g / L, set the rotation speed to 70 rpm, and react at 0.1 MPa and 50° C. for 8 h. Finally, the carboxymethyl chitosan-modified nano-selenium water solution was filtered through a filter membrane (molecular weight cut-off: 10KD) to obtain the purified carboxymethyl chitosan-modified nano-selenium water solution, which was stored at 4°C.

[0053] The experimental results show that although carboxymethyl chitosan is easy to dissolve in water, when the Vc aqueous solution is added dropwise to the mixed solution of carboxymethyl chitosan and sodium selenite, nano-selenium quickly coagulates, ...

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Abstract

The invention belongs to the field of selenium resource utilization, and particularly relates to a method for preparing polysaccharide modified nanometer selenium on a large scale and application. According to the method, a polysaccharide water solution and a reducing agent water solution are mixed, then deionized water is added into the mixture, then a mixed solution is obtained, then a sodium selenite water solution is added for uniform stirring, then purifying is conducted, and therefore a polysaccharide modified nanometer selenium water solution is obtained. The preparing method for industrially producing nanometer selenium on a large scale is simple, and the problems of corrosion and contamination caused by acetic acid during industrialized production are well solved. The scale of a reaction system is enlarged to an industrial level, which is a great breakthrough compared with other small-scale laboratory reaction systems. The prepared polysaccharide modified nanometer selenium has the size of 80-120 nm, and is stable. In this way, the polysaccharide modified nanometer selenium can be widely applied to rich-selenium products, rich-selenium foods and all kinds of medicine products.

Description

technical field [0001] The invention belongs to the field of selenium resource utilization, and in particular relates to a large-scale preparation method and application of polysaccharide-modified nano-selenium. Background technique [0002] Selenium is an essential trace element for animals and plants, and it plays a role in antioxidant defense, immune regulation and anti-aging. Selenium deficiency is one of the common diseases of poultry and livestock. The human body cannot synthesize selenium by itself and must be ingested from the outside world. Selenium is an ultra-trace element in geochemistry. Natural selenium has only one stable isotope, and its atomic weight is 79. According to the prior art, it is known that the gray element selenium and the black element selenium are almost inactive and toxic, while the understanding of the biological properties of the red element selenium is vague. Selenium is a metalloid element in the fourth cycle. The research of Chinese sci...

Claims

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Application Information

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IPC IPC(8): C01B19/02B82Y30/00
CPCB82Y30/00C01B19/02
Inventor 陈填烽陈义康李海伟桑诚诚贺利贞
Owner GUANGDONG JINAN ESTABLISHED SELENIUM SOURCE NANO TECH RES INST CO LTD
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