Benzothiophene-pyrone type compound and synthesis method thereof

Abstract

The invention discloses a benzothiophene-pyrone type compound and a synthesis method thereof. The synthesis method comprises the following steps: firstly, weighing 4-thiophenyl pyran-2-ketone as a rawmaterial; mixing the weighed raw material with a solvent, and adding a catalyst and an oxidant to carry out a heating reaction; separating and purifying the obtained reaction product to obtain the benzothiophene-pyrone type compound. Defects that present synthesis reactions have harsh conditions, a substrate is hard to prepare, the reaction yield is low, and the like, can be avoided, reaction steps are simplified, and the reaction yield is increased.

Description

technical field

[0001] The invention belongs to the field of organic synthesis, and in particular relates to a benzothienopyrone compound and a synthesis method thereof. Background technique

[0002] It is well known that pyrone and thiophene derivatives are important heterocyclic compounds, which widely exist in natural products and many drug molecules. The strategies for synthesizing these two compounds have reached a relatively mature level. [a) MacDowell, D.W.; Jourdenais, R.A.; Naylor, R.W.; J. Org. Chem. 1972, 37, 4406. b) Bolognese, A.; Correale, G.; , E.; Lavecchia, A.J.Med.Chem.2008,51,8148.c) Li, C.; Liu, M.; Pschirer, N.G.; Baumgarten, M.; 6817.d) Lin, Y.; Li, Y.; Zhan, X. Chem. Soc. Rev. 2012, 41, 4245.]. Based on the practicability and importance of these two heterocyclic compounds, chemists have been continuously exploring the synthesis methods of benzothienopyrone derivatives. However, relatively speaking, there are few reports on the specific synthesis of...

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