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Calprotectin combined with lactoferrin antigen test strip and preparation method thereof

A technology of lactoferrin and calprotectin, applied in biological testing, measuring devices, material inspection products, etc., can solve problems such as long operation time, inability to check the gastrointestinal tract, discomfort, etc., achieve high sensitivity, improve sensitivity and Specific, highly specific effects

Pending Publication Date: 2019-04-26
ZHUHAI ENCODE MEDICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it is invasive, invasive, does not examine the entire GI tract, and requires skilled operators and uncomfortable bowel preparation
The commonly used detection methods for calprotectin include enzyme-linked immunosorbent assay and fluorescent enzyme-linked immunoassay. The enzyme-linked immunosorbent assay and fluorescent enzyme-linked immunoassay have high sensitivity and are suitable for professional detection. The operation time is long and requires professionals. operate

Method used

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  • Calprotectin combined with lactoferrin antigen test strip and preparation method thereof

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Embodiment 1

[0026] like figure 1 As shown, in this embodiment, the calprotectin combined with lactoferrin detection test strip includes a base plate 1, and a sample pad 2, a marking pad 3, a detection pad 4, and a water-absorbing pad 5 are sequentially overlapped on the base plate 1 , the detection pad 4 is provided with a calprotectin detection line T1, a lactoferrin detection line T2 and a quality control line C, the calprotectin detection line T1 is coated with a calprotectin antigen, and the lactoferrin detection line T2 is coated with lactoferrin antigen, and the quality control line C is coated with goat anti-mouse or goat anti-rabbit IgG.

[0027] The calprotectin detection line T1 and the lactoferrin detection line T2 are close to the marker pad 3 , and the quality control line C is close to the absorbent pad 5 .

[0028] The detection pad 4 is made of nitrocellulose membrane, and the marker pad 3 is made of glass cellulose.

[0029] A preparation method of a calprotectin combin...

Embodiment 2

[0047] The difference between this embodiment and the first embodiment: In this embodiment, the control line 232 is composed of goat anti-mouse IgG antibody.

[0048] The invention is applied in the technical field of test strips for detection of intestinal inflammatory disease marker protein.

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Abstract

The invention discloses a calprotectin combined with lactoferrin antigen test strip and a preparation method thereof, and aims to provide a calprotectin combined with lactoferrin test strip with highdetection speed, simple operation and high sensitivity and also provides a preparation method of the calprotectin combined with lactoferrin test strip with simple process, good repeatability, stable finished structure and good performance. The calprotectin combined with lactoferrin antigen test strip comprises a bottom plate, a sample pad, a marker pad, a test pad and an absorbent pad. The preparation method comprises the steps that firstly the sample pad, the marker pad and the test pad are prepared, and then the sample pad, the marker pad, the test pad and the absorbent pad are in lap jointon the bottom plate in sequence. The calprotectin combined with lactoferrin antigen test strip is applied to the technical field of intestinal inflammatory disease marker protein detection test strips.

Description

technical field [0001] The invention relates to the technical field of test strips for detection of intestinal inflammatory disease marker proteins, in particular to a test strip for detection of calprotectin combined with lactoferrin antigen and a preparation method thereof. Background technique [0002] Calprotectin belongs to the S-100 family and is a calcium-zinc binding protein with a relative molecular mass of 36kDa. It is a heterotrimer composed of two MRP-8 chains and one MRP-14 chain, mainly derived from Neutrophils are important markers of neutrophil renewal. The presence of calprotectin in feces is a hallmark of gastrointestinal proliferative disorders and intestinal inflammatory infectious diseases. In general, it is difficult to distinguish the discomfort caused by acute intestinal irritation from chronic infectious gastrointestinal diseases from the symptoms of the disease alone, which leads to unnecessary and excessive abuse of colonoscopy. A marker of tract...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/558G01N33/532
CPCG01N33/532G01N33/558G01N33/6893G01N2800/065
Inventor 孙宜峰曾冰冰崔淑珍
Owner ZHUHAI ENCODE MEDICAL ENG
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