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Aromatic helical foldamer as well as preparation method and application of aromatic helical foldamer

A folded body and helix technology, applied in the field of aromatic helical folded body and its preparation, can solve the problems of formation mechanism and specific conformational arrangement research difficulties, and achieve the effect of great application prospects

Inactive Publication Date: 2019-05-03
JILIN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the construction of the supramolecular helix is ​​simpler than the above two, the research on its formation mechanism and specific conformational arrangement is slightly difficult

Method used

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  • Aromatic helical foldamer as well as preparation method and application of aromatic helical foldamer
  • Aromatic helical foldamer as well as preparation method and application of aromatic helical foldamer
  • Aromatic helical foldamer as well as preparation method and application of aromatic helical foldamer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The synthetic route of preparing the trimer oligomer containing bisacyl chloride active group is as follows:

[0052]

[0053]

[0054] The preparation method specific steps of the trimer oligomer containing bisacyl chloride active group are as follows:

[0055] Step A: Dissolve 10g of 2-aminobenzamide in a round-bottomed flask with 30ml of anhydrous methanol, feed 10g of 2-aminobenzamide and dimethyl butyndioate in a molar ratio of 1:1.1, and Dissolve dimethyl alkynedioate in 15ml of anhydrous methanol, then slowly add it dropwise into a round bottom flask, stir at room temperature until it is evenly mixed, and heat to reflux for 8 hours.

[0056] Let stand to room temperature, and put in a -20°C refrigerator overnight. The next day, filter and wash the filter cake repeatedly with ice methanol until the filtrate is colorless and clear. The bright yellow product 1,2-(2-carbamoylphenyl)amino)maleic acid dimethyl was collected after being fully dried at 30° C. in ...

Embodiment 2

[0087] The synthetic route of preparing the trimer oligomer containing bisacyl chloride active group is as follows:

[0088]

[0089]

[0090] The specific steps of the preparation method of the trimer containing the bisacyl chloride active group are as follows:

[0091] Step A: Dissolve 10g of 2-aminobenzamide in a round-bottomed flask with 30ml of anhydrous methanol, feed 10g of 2-aminobenzamide and dimethyl butynedate at a molar ratio of 1:1.3, and first add Dissolve dimethyl alkynedioate in 17ml of anhydrous methanol, then slowly add it dropwise into a round bottom flask, stir at room temperature until it is evenly mixed, and heat to reflux for 8 hours.

[0092] Allow to cool to room temperature and place in a -20°C refrigerator overnight. The next day, suction filtration was performed and the filter cake was repeatedly washed with ice methanol until the filtrate was colorless and clear. Finally, the filter cake was put into a vacuum drying oven, and after being fu...

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Abstract

The invention discloses an aromatic helical foldamer as well as a preparation method and application of the aromatic helical foldamer. The aromatic helical foldamer provided by the invention is dimethyl8,8'-((8,8'-(((pyridine-2,6-dicarbonyl)bis(aza-2-yl))bis(carbonyl))bis(4-isobutoxyquinoline-2,2'-carbonyl))bis(nitroalkyl-2-yl))bis(4-(2-(tert-butoxy)-2-oxyethoxy)quinoline-2-tert-butyl carboxylate.A synthesis method comprises the steps: firstly, preparing 8,8'-((pyridine-2,6-dicarbonyl)bis(aza-2-yl))bis(carbonyl))bis(4-isobutoxyquinoline-2-carbonyl chloride, and then, preparing the target aromatic helical foldamer. At present, a helical structure shows an unprecedented potential in the fields such as chiral separation, molecular recognition and display material, the aromatic helical foldamer is successfully synthesized, and novel thoughts and approaches are provided for the construction of an aromatic helical structure.

Description

technical field [0001] The invention belongs to the field of design and synthesis of a helical folded body, in particular to an aromatic helical folded body and its preparation method and application. Background technique [0002] Helical structures are important core structures in living organisms, and their functions are delicate and complex. The well-known DNA that can control heredity is the double helix structure, which can complete the storage and transmission of genetic information. In addition, the α-helix present in membrane proteins can realize the transmission and specific recognition of substances inside and outside the cell membrane. These helical structures all play very important roles in human life. Therefore, rational design and construction of artificial helix to imitate the function of natural helix is ​​a hot topic of current research. [0003] The artificial helical structure has great application potential in many aspects. For example, Zeng Huaqiang ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/14
Inventor 李文芳李传碧王家军刘春玲
Owner JILIN NORMAL UNIV
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