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A digestive system inflammation drug targeted delivery drug system

A technology of digestive system and inflammation, applied in the field of designing targeted drugs for inflammation, can solve the problems of drug internal organ toxicity, drug consumption, etc., and achieve the effect of strong targeting, improving therapeutic effect, and applying drugs accurately

Active Publication Date: 2021-01-29
李翠 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen that the current targeted therapy for inflammation is generally by directly injecting drugs and targeted materials into animals. Although in the current situation, the targeting has been greatly improved, there are still drugs that are consumed in the body and drug toxicity to other internal organs

Method used

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  • A digestive system inflammation drug targeted delivery drug system
  • A digestive system inflammation drug targeted delivery drug system

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0048] The preparation method of the system A is as follows:

[0049] Step A-1 Pretreatment of neutrophils: take the freshly prepared neutrophil suspension, incubate in the culture medium at 37°C for 1-5 hours, and remove the culture medium;

[0050] Add positively charged liposomes to the incubated neutrophils, add fresh culture medium to dilute, and incubate at 37°C for 1-2 hours;

[0051] Step A-2 Encapsulation of the first base sequence: Take the prepared first base sequence fragment, add fresh culture medium to dilute and negatively charged liposomes, ultrasonically disperse, and incubate at 37°C for 1-3 hours ;

[0052] Step A-3 connection of neutrophils and the first nucleotide sequence, the incubated neutrophils obtained in step A-1 and the incubated first nucleotide sequence fragments obtained in step A-2 are positively charged Liposomes and negatively charged liposomes are mixed at a mass ratio of 2-4:1, and incubated at 37° C. for 2 hours after mixing; neutrophils...

Embodiment 1

[0072] System A was prepared as follows:

[0073] Step A-1 Pretreatment of neutrophils: Take the freshly prepared neutrophil suspension, incubate in the culture medium at 37°C for 1 hour, and remove the culture medium;

[0074] Add positively charged liposomes to the incubated neutrophils, add fresh culture medium to dilute, and incubate at 37°C for 2 hours;

[0075] Step A-2 Encapsulation of the first base sequence: take the prepared first base sequence fragment, add fresh culture medium to dilute and negatively charged liposomes, ultrasonically disperse, and incubate at 37°C for 3 hours;

[0076] Step A-3 connection of neutrophils and the first nucleotide sequence, the incubated neutrophils obtained in step A-1 and the incubated first nucleotide sequence fragments obtained in step A-2 are positively charged Liposomes and negatively charged liposomes were mixed at a mass ratio of 2:1, and incubated at 37° C. for 2 hours after mixing; neutrophils connected with the first base...

Embodiment 2

[0092] System A was prepared as follows:

[0093] Step A-1 Pretreatment of neutrophils: take the freshly prepared neutrophil suspension, incubate in the culture medium at 37°C for 2 hours, and remove the culture medium;

[0094] Add positively charged liposomes to the incubated neutrophils, add fresh culture medium to dilute, and incubate at 37°C for 1 hour;

[0095] Step A-2 Encapsulation of the first base sequence: take the prepared first base sequence fragment, add fresh culture medium to dilute and negatively charged liposomes, ultrasonically disperse, and incubate at 37°C for 2 hours;

[0096] Step A-3 connection of neutrophils and the first nucleotide sequence, the incubated neutrophils obtained in step A-1 and the incubated first nucleotide sequence fragments obtained in step A-2 are positively charged Liposomes and negatively charged liposomes were mixed at a mass ratio of 2:1, and incubated at 37° C. for 2 hours after mixing; neutrophils connected with the first base...

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Abstract

The invention relates to the field of targeted drugs designed for inflammation, in particular to a targeted drug delivery system and devicefor inflammation treating drugs in digestive system. Base sequences are respectively connected to neutrophils and an inflammation treating drug, and the neutrophils can be injected into an animal body when in use, and the inflammation treating drug is applied to extracellular inflammation, so that the problems are avoided that the inflammation drug is damaged to other organs and the inflammation drug is consumed in vivo when the inflammation treating drug is directly applied to the animal body. Especially, the system has the good treatment effect on inflammation of digestive systems, such as esophagus, gastrointestinal organs and the like. When the system A and the system B are used for treatment, a drug A can be directly injected into the animal body along the vein, the system B is administered through a digestive system inflammation targeted inspection and repair device provided by the invention, the retention state of the drug on the inner wall of the digestive system organ can be further observed after administration, and image support is provided for examination and positioning of inflammation.

Description

technical field [0001] The invention relates to the field of targeted drug design for inflammation, in particular to a drug delivery system and a drug delivery device for targeted delivery of digestive system inflammation drugs. Background technique [0002] Targeted therapy is a treatment method aimed at an already identified cancer-causing site at the cellular molecular level (the site can be a protein molecule inside a tumor cell or a gene fragment). Corresponding therapeutic drugs can be designed. When the drugs enter the body, they will specifically select the carcinogenic sites to combine and act, so that the tumor cells can die specifically without affecting the normal tissue cells around the tumor. Therefore, molecular targeted therapy is also called "Biological Missile". [0003] Regarding the targeted therapy of inflammation, the application number 201510142691.3 discloses a targeted reagent for multimodal diagnosis and treatment of inflammation-related diseases, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K47/26A61K47/46A61K45/00A61P1/00A61P29/00A61M31/00
Inventor 李翠吴志宏
Owner 李翠
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