Preparation method for potassium chloroplatinite

Abstract

The invention discloses a preparation method for potassium chloroplatinite. The preparation method comprises the following steps: 1) dissolving spongy platinum in aqua regia for denitration, thereby acquiring a chloroplatinic acid solution; 2) dropwise adding the chloroplatinic acid solution into a potassium chloride solution and reacting; 3) washing the potassium chloride solution with ethyl alcohol, and then drying, thereby acquiring potassium chloroplatinate; 4) uniformly mixing deionized water and potassium chloroplatinate, thereby forming a turbid liquid; dropwise adding hydroxylamine hydrochloride solution and potassium hydroxide solution in turn; removing platinum black by filtering under a heat state after the ending of reaction, thereby acquiring the potassium chloroplatinite solution; 5) performing rotary evaporation on the potassium chloroplatinite solution, and then cooling and filtering, and vacuum-drying, thereby acquiring solid potassium chloroplatinite. According to theinvention, hydroxylamine hydrochloride is used as a reducing agent for reducing potassium chloroplatinate, potassium hydroxide is used for neutralizing excessive acid in the system, and potassium chloroplatinate is completely reduced to potassium chloroplatinite, so that high-purity potassium chloroplatinite is prepared. The quality purity of the prepared potassium chloroplatinite is more than orequal to 99.5%, potassium chloroplatinate residue is less than or equal to 0.04% and yield is above 92.2%.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical intermediates, and in particular relates to a preparation method of potassium chloroplatinite. Background technique [0002] Cancer is currently one of the major diseases that seriously affect human health and threaten human life, so the development of anticancer drugs has become a research hotspot. Since American scientist Rosenberg discovered that cisplatin has the ability to inhibit tumor cell growth in 1967, the research and clinical application of platinum-based drugs in tumor treatment has achieved rapid development. Cisplatin, carboplatin and oxaliplatin have become mature anti-tumor drugs, and the market demand is increasing year by year. The new generation of platinum-based anti-tumor drugs such as leplatin and cycloplatin will further expand the application of platinum-based compounds in anti-tumor treatment. application. [0003] Potassium chloroplatinite is an i...

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Problems solved by technology

[0009] In the above 4 kinds of methods for preparing potassium chloroplatinite, CN101279772A, CN102774894A and CN103253718B all have the problem of incomplete reduction in the reduction process, thereby affecting the product purity of potassium chloroplatinite. CN102390874A reduces chloroplatinic acid solution with oxalic acid, due to chlorine The acidity of the platinum acid solution is difficult to be strictly controlled, the reduction process is not repeatable, and the phenomenon of incomplete platinum reduction is prone to occur, which affects the purity of potassium chloroplatinite.