Formula and preparation method of POSS-based regenerative medical material

A technology for medical materials and formulations, applied in medical science, prostheses, etc., can solve the problems of low strength and few reactive groups, achieve high biological activity, and achieve simple effects

Active Publication Date: 2019-05-21
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of this, the main purpose of the present invention is to provide a formulation and preparation method of POSS-based regenerative medical materials, which solves the problems of brittleness and low strength of traditional bioactive glass, and also solves the problem of reactivity in traditional bioactive glass. The problem of too few groups

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  • Formula and preparation method of POSS-based regenerative medical material
  • Formula and preparation method of POSS-based regenerative medical material

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Experimental program
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Effect test

Embodiment 1

[0023] A formulation of POSS-based regenerative medicine material, comprising the following formulations in parts by weight:

[0024] Trialkoxysilane 80 parts

[0025] Methanol 72 parts

[0026] 22 parts of deionized water

[0027] Concentrated hydrochloric acid 3.2 parts

[0028] Phytic acid 5 parts

[0029] Contains 23 parts of calcium salts.

[0030] The preparation method of the formula of the POSS-based regenerative medicine material of the present embodiment comprises:

[0031] First, add 72 parts of methanol and 22 parts of deionized water into the reactor, then add 3.2 parts of catalyst concentrated hydrochloric acid and stir evenly, and measure the pH between 0.8-1.3;

[0032] Then, 80 parts of trialkoxysilane was added dropwise, and after the dropwise addition was completed, the mixture was stirred and reacted at 30-50°C for 6-8 hours to carry out the hydrolysis reaction;

[0033] Then, add 5 parts of phytic acid to promote polycondensation, and add 23 parts of...

Embodiment 2

[0043] A formulation of POSS-based regenerative medicine material, comprising the following formulations in parts by weight:

[0044] Trialkoxysilane 68 parts

[0045] Methanol 66 parts

[0046] 20 parts deionized water

[0047] 3 parts concentrated hydrochloric acid

[0048] Phytic acid 7 parts

[0049] Contains 25 parts of calcium salts.

[0050] The preparation method of the formula of the POSS-based regenerative medicine material of the present embodiment comprises:

[0051] First, add 66 parts of methanol and 20 parts of deionized water into the reactor, then add 3 parts of catalyst concentrated hydrochloric acid and stir evenly, and measure the pH between 0.8-1.3;

[0052] Then, 68 parts of trialkoxysilane was added dropwise, and after the dropwise addition was completed, the reaction was stirred at 30-50°C for 6-8 hours, and the hydrolysis reaction was carried out;

[0053] Then, add 7 parts of phytic acid to promote polycondensation, and add 25 parts of calcium-c...

Embodiment 3

[0062] A formulation of POSS-based regenerative medicine material, comprising the following formulations in parts by weight:

[0063] Trialkoxysilane 56 parts

[0064] Methanol 64 parts

[0065] 18 parts deionized water

[0066] 3 parts concentrated hydrochloric acid

[0067] Phytic acid 9 parts

[0068] Contains 28 parts of calcium salts.

[0069] The preparation method of the formula of the POSS-based regenerative medicine material of the present embodiment comprises:

[0070] First, add 64 parts of methanol and 18 parts of deionized water into the reactor, then add 3 parts of catalyst concentrated hydrochloric acid and stir evenly, and measure the pH between 0.8-1.3;

[0071] Then, 56 parts of trialkoxysilane was added dropwise, and after the dropwise addition was completed, the mixture was stirred and reacted at 30-50°C for 6-8 hours to carry out the hydrolysis reaction;

[0072] Then, add 9 parts of phytic acid to promote polycondensation, and add 28 parts of calciu...

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Abstract

The invention discloses a formula and a preparation method of a POSS-based regenerative medical material. The formula comprises 38-80 parts of trialkoxysilane, 40-72 parts of methanol, 10-22 parts deionized water, 2.6-3.2 parts of concentrated hydrochloric acid, 5-20 parts of phytic acid and 23-36 parts of calcium-containing salt, and a calcium and phosphorus element inlaid novel bioactive material with a cage structure composed of a Si-O- Si bond framework of silicon oxide is formed by adopting a specific proportion and accordingly achieves higher bioactivity. The material can achieve molecular hybridization enhancement with other medical macromolecules; The active groups on the periphery of the cage structure can be grafted with target functional groups so as to realize targeted repair.

Description

technical field [0001] The invention relates to a formula and a preparation method of a POSS-based regenerative medical material. Background technique [0002] At present, bioactive materials that can be implanted into the human body and induce tissue regeneration have been the unremitting pursuit of modern medicine. During this development process, bioactive glass has always been a hot spot in this research field; this kind was developed by Professor L.L.Hench of the University of Florida in the 20th century The material invented in the 1970s has a wide range of applications due to its direct bonding with human bones. After decades of development, the process of bioactive glass is also being gradually optimized. From the initial high-energy and high-pollution melt quenching method to the current relatively environmentally friendly sol-gel method, the process has gradually stabilized. However, some performance defects of bioactive glass limit its application field. The low ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/50A61L27/58
Inventor 胡方郭创洲王健罗国东
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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