A rotary table device used for producing microdroplets from a liquid material and a device for producing microspheres

A liquid material, turntable technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of limited turntable method, small force, uneven force, etc., to ensure drug safety, reduce residual levels, The effect of uniform particle size

Pending Publication Date: 2019-05-21
ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the current turntable devices are not ideal enough. The droplet generating device used in CN101816913A has a structure similar to a turntable, but it needs to add the mixed liquid evenly to the center of the rotating disc, otherwise it cannot ensure that the droplets are evenly dispersed on the disc. All directions, and the disc is a horizontal disc, the resistance of the micro-droplets is small, so the freedom of movement of the micro-droplets is relatively large, and it is easy to be unevenly stressed, so the appearance of the microspheres obtained by this patented method is not round enough.
If it is a high-viscosity liquid, it is far from enough to rely on the high-speed centrifugal force of the flat disc to disperse, even if the ultra-high speed is used, it is not good for equipment protection
[0010] The rotating disk method mentioned in US7758778B2 and CN103260603B is very limited in practical application, and the reason is that it utilizes centrifugal force and surface tension to stretch the active force of material liquid into a ball too small, for those material solutions with larger viscosity and little surface tension very restricted

Method used

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  • A rotary table device used for producing microdroplets from a liquid material and a device for producing microspheres
  • A rotary table device used for producing microdroplets from a liquid material and a device for producing microspheres
  • A rotary table device used for producing microdroplets from a liquid material and a device for producing microspheres

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Experimental program
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Effect test

Embodiment 1

[0043] Such as Figure 1-3 As shown, a turntable device for producing droplets from liquid materials, the device is a turntable structure, a cup-shaped container 24 and its first driving device 33 are arranged in the center of the turntable structure, and the outside of the cup-shaped container 24 At least two layers of butterfly turntables are sequentially nested, and each layer of butterfly turntables is equipped with a corresponding driving device. Two layers of butterfly turntables are provided in the accompanying drawings, that is, the first layer of butterfly turntables 26 and the second layer of butterfly turntables 28, the first layer of butterfly turntables 26 are driven to rotate by the second drive device 34, and the second layer of butterfly turntables 28 is driven to rotate by the third driving device 35, and the first driving device 33, the second driving device 34 and the third driving device 35 can be high-speed rotary motors, or strong magnetic high-speed moto...

Embodiment 2

[0048] Such as Figure 4 Shown, a kind of equipment for making microsphere, described equipment comprises main tank body 23 and embodiment 1 and is used for producing the turntable device of liquid material droplet, the bottom of described turntable device is supported by auxiliary structure 39 is installed in the main tank body 23;

[0049] The main tank 23 is an inverted tapered stainless steel double-layer tank capable of withstanding positive pressure, and a first temperature control element 40 that can adjust temperature is installed on the side wall of the tank. The first temperature control element 40 may be a temperature control water bath placed outside the jacket layer of the main tank body 23 .

[0050] The minimum inner diameter of the main tank body 23 is preferably more than 80 cm. When the longest diameter disc-shaped turntable rotates at the highest rotational speed, the droplets that fly out do not contact the inner wall of the main tank body 23 . Any target...

Embodiment 3

[0065] (1) Dissolve 25g of triamcinolone acetonide acetate and 75g of PLGA7525 in 375g of dichloromethane to obtain a uniformly dispersed solution with a viscosity of 285cp; this step is obtained in the sample preparation device.

[0066] (2) The homogeneous solution described in step (1) is supplied into the cup-shaped container 24 through the liquid supply port 22 (liquid supply speed 5mL / min), the first driving device 33 is adjusted, the rotating speed of the cup-shaped container 24 is set to 40m / s, the first The rotational speed of the disc-shaped turntable 26 on the first layer is 80m / s, and the rotational speed of the second-layer disc-shaped turntable 28 is 150m / s. The surface of the turntable 26 is dispersed into droplets, and the formed droplets continue to hit the second layer of dish-shaped turntable 28 that runs in the opposite direction. Under the effect, the organic solvent volatilizes continuously, and the solidified microspheres are collected by the first sampl...

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Abstract

A rotary table device used for producing microdroplets from a liquid material and a device for producing microspheres are provided. The rotary table device has a rotary table structure the center of which is provided with a cup container and a driver thereof. At least two dish-shaped rotary table layers are embedded outside the cup container in order, with each dish-shaped rotary table layer beingprovided with a corresponding driver. A power unit below the cup container is started, a material solution in the cup container passes through the cup opening under the function of high-speed centrifugal force and hits the surface of an outer dish-shaped rotary table under functions of centrifugal force and impact force to form microdroplets; the formed microdroplets move to the edge of the rotary table and hit the surface of an outer dish-shaped rotary table having a larger inner diameter; after two or more times, the microdroplets move to the edge of the outer dish-shaped rotary table having the largest inner diameter, fly out of the rotary table and gradually cure to form microspheres; and then the dried microspheres are collected by a collector below the rotary table device.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a turntable device for producing microdrops from liquid materials and equipment for manufacturing microspheres. Background technique [0002] Microspheres refer to the microparticle dispersion system formed by dispersing or adsorbing drugs in macromolecules and polymer matrices. There are many carrier materials for preparing microspheres, which are mainly divided into natural polymers and synthetic polymers. Poly(lactic-co-glycolic acid) (PLGA) is by far the most researched, safest and most widely used synthetic polymer carrier material. Up to now, among the more than ten microsphere products that have been on the market, except and are lipid microspheres, and the rest are PLGA microspheres. Microspheres can be administered orally, intramuscularly, subcutaneously, intravitreally and intraarticularly, to increase the residence time of drugs in specific parts, increase loc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04
Inventor 于崆峒蒋朝军
Owner ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
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