A kind of preparation method of 3-peroxy-2-indolone compound in water phase
A technology of indolinone and peroxy, which is applied in the field of preparing 3-peroxy-2-indolinone compounds, can solve problems such as unsatisfactory reaction yields, and achieve the effect of simple operation and easy purification
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Embodiment 1
[0031]
[0032] In the Schlenk bottle, add 2-indolinone derivatives (41.8 mg, 0.2 mmol) shown in formula 1a, tert-butanol peroxide (t-BuOOH, 43.2 mg, 0.48 mmol), then add solvent water (2 mL), Then the reactor was stirred and reacted in an air atmosphere at 60°C, and the reaction process was monitored by TLC until the raw materials disappeared (reaction time was 24 hours). After the reaction was completed, the reaction solution was extracted three times with ethyl acetate, and the organic phase was extracted with anhydrous Dry over sodium sulfate, filter and concentrate under reduced pressure to remove the solvent, and the residue is separated by column chromatography (elution solvent: ethyl acetate / n-hexane) to obtain the target product I-1. (42% yield); 1 H NMR (400MHz, CDCl 3 )δ: 8.62(s, 1H), 7.45-7.43(m, 2H), 7.34-7.25(m, 5H), 7.08(t, J=8.0Hz, 1H), 6.90(d, J=7.6Hz, 1H ), 1.19(s, 9H); 13 C NMR (100MHz, CDCl 3 )δ: 176.3, 141.7, 136.0, 129.8, 129.0, 128.9, 128.5, 127.0...
Embodiment 2
[0034] The reaction temperature was increased to 80° C., and the other conditions were the same as in Example 1. The yield of the target product I-1 was 94%.
Embodiment 3
[0036] The reaction temperature was raised to 100° C., and the rest of the conditions were the same as in Example 1. The yield of the target product I-1 was 92%.
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