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Powder-needle nitrogen filling device and nitrogen filling method

A powder injection and nitrogen technology, applied in the direction of pressurization/gasification packaging, screwless plugs, etc., can solve the problems of complex design, inability to popularize and use, and the residual oxygen content cannot be effectively controlled, and achieves simple structure and debugging. convenient effects

Pending Publication Date: 2019-05-28
SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The first method is complex in design, and the mechanical structure needs regular maintenance
In the second method, the medicine bottle needs to be transferred, the production efficiency is low, and there may be a risk of bacterial contamination during the transfer process
The current third nitrogen filling method cannot be widely used because the residual oxygen content cannot be effectively controlled.

Method used

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  • Powder-needle nitrogen filling device and nitrogen filling method
  • Powder-needle nitrogen filling device and nitrogen filling method
  • Powder-needle nitrogen filling device and nitrogen filling method

Examples

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Embodiment 1

[0040] See figure 1 , a kind of powder needle nitrogen charging device designed in the preferred embodiment of the present invention, it mainly includes: buffer tank 30 and diversion gas charging mechanism, this device is used together with conveying belt 5 and rubber plug wheel mechanism 6, completes the medicine bottle Nitrogen filling, each component and connection relationship will be described in detail below.

[0041] See Figure 1 to Figure 3 , The buffer tank 30 includes: a cylindrical tank body 31 , an air source mouthpiece 32 protruding and inserted in the middle of the bottom end of the tank body 31 , and a distribution seat 33 sealed and installed on the top end of the tank body 31 . The end of the gas source interface tube 32 is a quick-loading chuck at the gas source inlet, which is directly connected to the pipe mouth clamp of the nitrogen source. The other end of the gas source interface tube 32 inserted into the tank body 31 adopts a sealing design, so it mus...

Embodiment 2

[0062] A method for filling nitrogen into powder needles according to the second preferred embodiment of the present invention, specifically comprising:

[0063] First use the nitrogen filling device described in the preferred embodiment 1 to form a nitrogen filling channel that continuously sprays nitrogen gas. The length of the nitrogen filling channel is not less than 350mm, and the height of the nitrogen filling channel from the bottle mouth is 3mm. The nitrogen source pressure of the nitrogen filling device Not less than 8psi, the powder-filled medicine bottle passes directly under the nitrogen filling channel at a speed of 224 bottles per minute on the conveyor belt, and the bottle is filled with nitrogen gas; after passing through the nitrogen filling channel, the rubber plug wheel mechanism is used to The bottle mouth is pressed into the rubber stopper.

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Abstract

The invention discloses a powder-needle nitrogen filling device. The powder-needle nitrogen filling device comprises a buffering tank and a flow-division inflation mechanism, wherein the buffering tank and the flow-division inflation mechanism are connected with a nitrogen source; the flow-division inflation mechanism comprises an air division cover and an air cavity box; the air division cover comprises a cover plate, air inlet interface tubes which communicate with the buffering tank through silicon rubber hoses, and air dividing tubes which horizontally and fixedly communicate with the bottom ends of the air inlet interface tubes; the air inlet interface tubes are inserted and fixed to the cover plate; multiple groups of primary air dividing holes are provided with an opening; the coverplate covers the opening; the air dividing tubes are positioned in the middle of a cavity body of the air cavity box; secondary air dividing holes which are arranged into columns are formed in the bottom face of the air cavity box; and a nitrogen filling channel is formed by the secondary air dividing holes which can continuously eject out nitrogen. The powder-needle nitrogen filling device disclosed by the invention has the advantages that through two-stage air dividing channels, the nitrogen is uniformly and slowly injected into a medicinal bottle, so that medicinal powder which is filled with the medicinal bottle cannot be blown out, and entrance of the nitrogen into the medicinal bottle also can be ensured; and moreover, after the bottle is sealed by using a rubber plug, residual oxygen detector is used to detect, and an average value of the content of the residual oxygen is less than 0.5 percent.

Description

technical field [0001] The invention relates to an inflator, which is mainly used as a nitrogen inflator in the production of injection powder. Background technique [0002] In the production of sterile powder injections, for easily oxidized powders, it is necessary to fill the medicine bottle with nitrogen gas after filling the medicine powder to discharge the air in the medicine bottle, and then press the rubber stopper to seal. Due to the oxidation reaction between oxygen and the powder, impurities will be produced in the powder, and the color level of the powder will increase by several color levels from the original color, and finally the efficacy will decrease and bring unknown negative effects. Therefore, relying on the inertness of nitrogen to alleviate the change of the color level of the drug, so as to achieve the effect of improving the stability of the drug. [0003] There are three types of conventional nitrogen filling methods: [0004] 1. Before the medicine...

Claims

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Application Information

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IPC IPC(8): B65B31/06B67B1/04
Inventor 刘远新王孟李月联张斌朱晓东肖佳
Owner SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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