Cyanoacrylate material carrying antitumor drug
A technology of cyanoacrylate and cyanoacrylate diester is applied in the field of cyanoacrylate materials, which can solve the problems of easy overflow of liquid drugs and failure to achieve long-term administration.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0114] The preparation of embodiment 1 formula glue
[0115] Using cyanoacrylate monomers BCA, MOE-CA, CA-TEG-CA, CA-PEG 600 -CA, CA-PEG 2000 -CA, according to the recipe in Table 1 to prepare formula glue. Under the condition of nitrogen protection, the corresponding monomer components are mixed by stirring, shaking, etc., and a clear and transparent formula glue can be obtained. The formula glue is polymerized at normal temperature and pressure in the air to form a glue block. The degradation rate and bonding strength of the rubber blocks were tested, and the results are shown in Table 1.
[0116] The structure of each monomer is as follows:
[0117]
[0118] BCA R=-CH 2 -CH 2 -CH 2 -CH 3 CA-TEG-CA W=-(CH 2 CH 2 O) 3 -CH 2 CH 2 -
[0119] MOE-CA R=-CH 2 -CH 2 -O-CH 3 CA-PEG 600 -CA W=PEG 600
[0120] MOEOE-CA R=-CH 2 -CH 2 -O-CH 2 -CH 2 -O-CH 3 CA-PEG 2000 -CA W=PEG 2000
[0121] Table 1 The composition of the formula glue and the degradatio...
Embodiment 2
[0127] The preparation of embodiment 2 drug-loaded glue
[0128] The formula glue in Table 1 was mixed with fluorouracil, curcumin, doxorubicin, paclitaxel, and docetaxel respectively, and each drug was used in multiple mass ratios (0.1%, 0.25%, 0.5%, 0.75%, 1%, 1.25%, 1.5%, 2%, 2.5%), clear and transparent drug-loaded gel solutions can be obtained.
Embodiment 3
[0129] The in vitro drug release test of the drug-loaded glue of embodiment 3 different monomer formulations
[0130] Take the drug-loaded gel solution containing 1.25% fluorouracil as an example. Add 1.25% by mass fluorouracil to the formulated gels of groups A, F, G, I, J, K, and M, and mix them uniformly to obtain drug-loaded gels in the form of clear solutions. Take 0.1g drug-loaded gel solution and polymerize it into a gel block (area 2.5×1cm 2 ), placed in 50mL PBS solution (pH7.4), and then put the solution containing the gel pieces into a constant temperature shaker (SHZ-82A, JINTAN RONGHUA, China, 60rpm) at 37°C. Samples were taken at a certain time point to test the fluorouracil content in the solution, and then the drug release amount of each group was calculated. Determination of the content of fluorouracil: firstly, through the method of high performance liquid phase, different concentrations of standard products are configured, and the peak area-concentration s...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More 
PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.
