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Antibacterial anti-adhesion reinforcement tablet and preparation method and application thereof

An anti-adhesion and patch technology, applied in the field of medical materials, can solve the problems of low clinical application and popularity, failure of hernia patch repair, and inaccurate effect, so as to prevent and treat internal infection problems, promote wound healing, and antibacterial effects. long lasting effect

Pending Publication Date: 2019-06-28
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the requirements of laparoscopic hernia repair for hernia mesh are still focused on good tensile properties, biocompatibility, anti-infection and anti-adhesion, etc., in order to prevent the occurrence of laparoscopic hernia repair. Complications such as regional infection and intestinal obstruction caused by intra-abdominal adhesions lead to failure of hernia mesh repair
In terms of anti-infection and anti-adhesion performance, although this type of single-function product currently exists on the market, it is expensive, the effect is not accurate, and the clinical application and popularity are not high.

Method used

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  • Antibacterial anti-adhesion reinforcement tablet and preparation method and application thereof
  • Antibacterial anti-adhesion reinforcement tablet and preparation method and application thereof
  • Antibacterial anti-adhesion reinforcement tablet and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An antibacterial anti-adhesion patch, comprising a polypropylene mesh and a polytea polyphenol film and nano-silver particles coated on the surface of the polypropylene mesh, its preparation process is as follows:

[0031] S1. Weigh 0.5g of tea polyphenols, add it to 50mL of hydrochloric acid with a concentration of 2mol / L, and then add 30ml of DMSO solution;

[0032] S2. Soak the polypropylene mesh in the solution prepared in step S1, heat at 70° C., and magnetically stir for 48 hours. After the reaction, wash with water and dry at room temperature to obtain a polypropylene / tea polyphenol patch;

[0033] S3. Maintain neutral reaction conditions at room temperature, soak the polypropylene / tea polyphenol patch in 30mmol / L AgNO 3 After being in the solution for more than 12 hours, the magnetic stirring is continued to obtain an antibacterial and anti-adhesion patch.

Embodiment 2

[0035] An antibacterial anti-adhesion patch, comprising a polypropylene mesh and a polytea polyphenol film and nano-silver particles coated on the surface of the polypropylene mesh, its preparation process is as follows:

[0036] S1. Weigh 0.5g of tea polyphenols, add to 50mL of hydrochloric acid with a concentration of 2.5mol / L, and then add 35ml of DMSO solution;

[0037]S2. Soak the polypropylene mesh in the solution prepared in step S1, heat at 75° C., and magnetically stir for 40 hours. After the reaction, wash with water and dry at room temperature to obtain a polypropylene / tea polyphenol patch;

[0038] S3. Maintain neutral reaction conditions at room temperature, soak the polypropylene / tea polyphenol patch in 25mmol / L AgNO 3 After being in the solution for more than 12 hours, the magnetic stirring is continued to obtain an antibacterial and anti-adhesion patch.

Embodiment 3

[0040] An antibacterial anti-adhesion patch, comprising a polypropylene mesh and a polytea polyphenol film and nano-silver particles coated on the surface of the polypropylene mesh, its preparation process is as follows:

[0041] S1. Weigh 0.5g of tea polyphenols, add it to 50mL of hydrochloric acid with a concentration of 1.5mol / L, and then add 25ml of DMSO solution;

[0042] S2. Soak the polypropylene mesh in the solution prepared in step S1, heat at 65° C., and magnetically stir for 60 hours. After the reaction, wash with water and dry at room temperature to obtain a polypropylene / tea polyphenol patch;

[0043] S3. Maintain neutral reaction conditions at room temperature, soak the polypropylene / tea polyphenol patch in 35mmol / L AgNO 3 After being in the solution for more than 12 hours, the magnetic stirring is continued to obtain an antibacterial and anti-adhesion patch.

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Abstract

The invention relates to the technical field of medical materials and discloses an antibacterial anti-adhesion reinforcement tablet and a preparation method and application thereof. The antibacterialanti-adhesion reinforcement tablet comprises a polypropylene mesh, a poly-tea polyphenol membrane and nano-silver particles, and the poly-tea polyphenol membrane and the nano-silver particles wrap thesurface of the polypropylene mesh. The antibacterial anti-adhesion reinforcement tablet has an excellent antibacterial anti-adhesion effect, the raw materials are low in price and easy to obtain, therelated complications after the neoplasty of hernia reinforcement tablets can be reduced, the success rate of repairing of the hernia reinforcement tablets is increased, the clinical treatment effectof repairing of the hernia reinforcement tablets is improved, and the reinforcement tablet has good application prospects. The preparation method of the antibacterial anti-adhesion reinforcement tablet is simple, easy to implement and high in practicability.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an antibacterial and anti-adhesion patch and its preparation method and application. Background technique [0002] Hernia is a common disease in general surgery. Its concept is that the tissues and organs in the normal cavity of the human body leave the normal anatomical position through the weak part of the human body, which can lead to changes in organ function, incarceration, ischemic necrosis and other complications. Timely and effective clinical intervention is an important means to prevent complications. In my country, the number of new hernia cases is not less than 3.5 million each year, and more than half of the patients need surgical treatment. At least 1.8 million pieces of hernia repair materials are needed in my country every year. At present, the clinical treatment for such diseases mainly adopts surgical operation for hernia mesh repair. At present, the ...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/08A61L31/10A61L31/14A61L31/16
Inventor 杨梓锋王辉黄榕康吴丁财周铭洪过文泰林燕欢胡民辉罗坚王怀明秦秀森杨清云路婧焦燕叶新梅吴小剑兰平汪建平
Owner SUN YAT SEN UNIV