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Bioartificial liver reactor and operating method thereof

A bioartificial and reactor technology, applied in the field of medical devices, can solve the problems of complex fluid flow control operations, uneven perfusion, unfavorable liver cells, etc., and achieve the effect of material exchange and cell activity balance

Active Publication Date: 2022-03-29
SHANGHAI CELLIVER BIOTECHNOLOGY CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese invention patent application with the publication number CN101837151A discloses a control system and method for a two-way perfusion bioreactor. The invention is provided with a flow direction controller to automatically switch the flow direction of the fluid, and forms a filter between the filter membrane and the mandrel. Disconnected interstitial regions are created to avoid low exchange efficiency due to uneven perfusion, dead space, and clogging
However, although the reactor can simulate the cell culture and treatment stages of the bioartificial liver, due to the multiple fluid channels, the fluid flow control operation is complicated, which is not conducive to the effective oxygen supply to the liver cells to maintain the activity

Method used

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  • Bioartificial liver reactor and operating method thereof
  • Bioartificial liver reactor and operating method thereof
  • Bioartificial liver reactor and operating method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0071] Embodiment 1 of the present invention provides a first bioartificial liver reactor, the first bioartificial liver reactor has a first container body, a first control unit, a first drive unit, a first carrier unit, a second carrier unit and first delivery unit.

[0072] In this embodiment, the first control unit is arranged outside the first container body, and the first control unit has a first flow control unit, a first rate control unit and a first time control unit. The first conveying unit has a first liquid inlet part and a first liquid outlet part; the first liquid inlet part has a straight liquid inlet pipe and a liquid distribution cover.

[0073] The first carrier unit has a first bearing part, the second carrier unit has a second bearing part, the inside of the first bearing part and the inside of the second bearing part accommodate a carrier, and the first The structure of the bearing part is the same as that of the second bearing part.

[0074] Figure 3a...

Embodiment 2

[0117] This embodiment provides a second bioartificial liver reactor, the difference between the second bioartificial liver reactor and the first bioartificial liver reactor in Example 1 of the present invention is that the second bioartificial liver reaction The second drive unit of the device is a fixed pulley assembly.

[0118] Figure 9a It is a schematic structural diagram of the second drive unit in Embodiment 2 of the present invention. Figure 9b for Figure 9a The schematic diagram of the structure of the rotation axis along the B direction is shown.

[0119] refer to Figure 4a , Figure 9a and Figure 9b , the second drive unit 9 has the fixing member 341 , the rotating shaft 91 and the transmission belt 92 , and the direction B is perpendicular to the rotating shaft 91 . One end of the rotating shaft 91 passes through the center of the fixing member 341 to be electrically connected to a first rate control unit (not shown in the figure) of the first control un...

Embodiment 3

[0124]This embodiment provides a third bioartificial liver reactor, the difference between the third bioartificial liver reactor and the first bioartificial liver reactor in Example 1 of the present invention is that the third bioartificial liver reaction The third driving unit of the device has a slide rail and a mechanical arm, the third bioartificial liver reactor has a third carrier unit, the third carrier unit has a third loading part, and the third bioartificial liver reactor The liquid inlet pipe is opened on the side wall of the first container body.

[0125] Figure 10 It is a schematic structural diagram of the third bioartificial liver reactor in Example 3 of the present invention. Referring to Figure 3 and Figure 10 , the third driving unit (not shown in the figure) of the third bioartificial liver reactor 100 has a mechanical arm 102 and a slide rail 103, and a part of the second liquid inlet part 101 runs through the side wall of the cylindrical bottle body 33...

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Abstract

The invention provides a bioartificial liver reactor, which includes a container body, a control unit, a drive unit, a carrier unit and a delivery unit; the control unit includes a flow control unit, a rate control unit and a time control unit; the rate control unit Control the motion rate of the carrier unit to be 0.5-5mm / s, so that the drive unit drives the carrier unit or the liquid to perform periodic motion, and control the carrier in each motion cycle in combination with the time control unit The time for the hepatocytes in the unit to exchange substances in the liquid phase is 60-400s, and the time for controlling the hepatocytes to exchange substances in the gas phase is 5-120s to ensure that the hepatocytes can exchange with the liquid Sufficient contact can also obtain effective oxygen supply in the oxygen-containing gas, so that the liver cells can achieve a balance of material exchange and cell activity in the liquid and the oxygen-containing gas. The invention also provides the operation method of the bioartificial liver reactor.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a bioartificial liver reactor and an operating method thereof. Background technique [0002] Liver failure is the end-stage manifestation of various liver diseases, and the shortage of donors and high technical difficulty greatly limit the widespread implementation of liver transplantation. The bioartificial liver uses human-derived or animal-derived hepatocytes to replace the liver that cannot perform biological functions in the body through an in vitro bioreactor to perform compensatory functions, and provides an effective means for the treatment of liver failure. [0003] The bioreactor is the core part of the bioartificial liver. As a place where the patient's blood or plasma interacts with liver cells and exchanges substances, its performance is directly related to the efficiency and effect of artificial liver support. An ideal bioreactor is a dynamic system, and wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/36C12M1/00C12M3/00
CPCC12M41/48C12M41/34C12M41/00C12M25/00
Inventor 鄢和新
Owner SHANGHAI CELLIVER BIOTECHNOLOGY CO LTD