Use of clove volatile oil in preparing medicine for preventing and treating motion sickness

A technology of clove volatile oil and motion sickness is applied in the field of drug preparation of clove volatile oil for preventing motion sickness and relieving motion sickness, and can solve the problems of poor safety and use compliance, difficulty in playing its due role, and difficulty in taking traditional Chinese medicine, etc. question

Inactive Publication Date: 2019-07-19
SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs used to treat motion sickness in traditional Chinese medicine are mostly commonly used drugs, most of which cannot be used for a long time, and the taste is poor, which is not convenient for children to use
[0006] There are various types of drugs that can treat and prevent motion sickness, but their safety and compliance are poor, especially in children. Due to the characteristics of chemical drugs, children use chemical drugs. The taste makes it difficult to take the medicine, and it is difficult to play its due role

Method used

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  • Use of clove volatile oil in preparing medicine for preventing and treating motion sickness
  • Use of clove volatile oil in preparing medicine for preventing and treating motion sickness
  • Use of clove volatile oil in preparing medicine for preventing and treating motion sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 Oral clove volatile oil improves the mouse motion sickness index

[0036] The purpose of this example is to confirm the prevention and treatment effect of clove volatile oil on motion sickness.

[0037] Test drug

[0038] Clove volatile oil: cloves were purchased from the local Chinese herbal medicine market, and the extraction method was adopted (Li Peng, Zhang Qiongguang, Ding Yingping, Shi Zhaohua, Dai Hongjian. Comparison of different methods for extracting volatile oil from cloves[J]. Chinese Journal of Hospital Pharmacy, 2006(08): 945 -947.) mentioned steam distillation extraction.

[0039] experimental animals

[0040] 160 mice, weighing 18-22g, were purchased from Guangdong Medical Animal Center

[0041] Grouping and Administration

[0042] Experiment is established 8 groups, comprises, normal animal group, blank control group (model group), scopolamine control group, clove oil group (dose is 5mg / kg, 10mg / kg, 50mg / kg, 100mg / kg, 200mg / kg, 500mg ...

Embodiment 2

[0050] The improvement effect of clove volatile oil extracted by different extraction methods of embodiment 2 on mouse motion sickness index

[0051] The purpose of this example is to test whether the clove volatile oil obtained by different extraction methods has a significant difference in the prevention and treatment of motion sickness.

[0052] Test drug

[0053] Clove volatile oil: cloves were purchased from the local Chinese herbal medicine market, and the extraction method was adopted (Li Peng, Zhang Qiongguang, Ding Yingping, Shi Zhaohua, Dai Hongjian. Comparison of different methods for extracting volatile oil from cloves[J]. Chinese Journal of Hospital Pharmacy, 2006(08): 945 -947.) The 6 methods mentioned to extract clove volatile oil.

[0054] experimental animals

[0055] 160 mice, weighing 18-22g, were purchased from Guangdong Medical Animal Center

[0056] Grouping and Administration

[0057] Eight groups were set up in the experiment, including blank contro...

Embodiment 3

[0062] Example 3 The safety test of high-dose clove volatile oil to rats

[0063] The purpose of this example is mainly to initially observe the safety risk of clove volatile oil at higher doses, and to confirm that clove volatile oil has a larger therapeutic window and is feasible for actual clinical use.

[0064] Test drug:

[0065] Clove volatile oil: cloves were purchased from the local Chinese herbal medicine market, and the extraction method was extracted using the method in Example 1.

[0066] experimental method

[0067] The drug preparation method adopts the method in Example 1, and only the concentration of the drug solution is adjusted appropriately. Ready to use every day.

[0068] SD rats, SPF grade, a total of 60 (male) were introduced, and selected after the adaptation period, and the body weight of D0 male mice was 229-245 g.

[0069]

[0070] The appearance, signs, behavioral activities, glandular secretion, respiration, urine and feces properties, and ...

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PUM

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Abstract

The present invention discloses a use of clove volatile oil in preparing a medicine for preventing and treating motion sickness and particularly the use of the clove volatile oil in a medicinal composition for preventing and treating the motion sickness. The clove volatile oil can be prepared by a steam extraction method, a microwave extraction method, an ultrasonic extraction method, an n-hexaneextraction method, an ethanol extraction method, and a supercritical carbon dioxide extraction method. When the clove volatile oil is used for preventing and treating the motion sickness, use amount of the clove volatile oil is 0.001-0.1 g / kg body weight / time according to a therapeutic effective amount of animal (mouse) in-vivo experiments, the dose is converted into 0.005-0.5 g / 60 kg / time in human body, and more preferably, the dose ranges of the human body medication are 0.01 g-0.2 g / 60 kg body weight / time. The medicinal composition has relatively good preventive and therapeutic effects on the motion sickness by oral administration, has functions of preventing and alleviating symptoms of the motion sickness (such as carsickness, seasickness, etc.), and is prepared from medicinally and edibly homogenous traditional Chinese medicine of cloves, safer compared with existing chemicals in the market, and suitable for a wider range of people, especially children.

Description

technical field [0001] The invention relates to a new application of clove volatile oil, in particular to the application of clove volatile oil in the preparation of medicines for preventing motion sickness and alleviating motion sickness. Background technique [0002] In addition to bringing unprecedented convenience to people's life, fast transportation means also lead to a rapid increase in the incidence of motion sickness. [0003] Motion sickness refers to general discomfort caused by riding various means of transportation. The main symptoms are dizziness, nausea, vomiting, and cold sweats. Periodic nausea and vomiting are characteristic and may be preceded by yawning, hyperventilation, salivation, pallor, profuse cold sweats, and lethargy. Aerophagia, dizziness, headache, general malaise, and fatigue may also occur. Nausea and vomiting can lead to weakness, difficulty concentrating, or severe nausea. With the prolongation of time in the exercise environment, the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61P1/08A61P43/00A61P25/00
CPCA61K36/61A61P1/08A61P25/00A61P43/00
Inventor 冯贻东唐田宝艳儒黄传贵冯汉林曾伟珍
Owner SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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