Use of clove volatile oil in preparing medicine for preventing and treating motion sickness
A technology of clove volatile oil and motion sickness is applied in the field of drug preparation of clove volatile oil for preventing motion sickness and relieving motion sickness, and can solve the problems of poor safety and use compliance, difficulty in playing its due role, and difficulty in taking traditional Chinese medicine, etc. question
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Embodiment 1
[0035] Embodiment 1 Oral clove volatile oil improves the mouse motion sickness index
[0036] The purpose of this example is to confirm the prevention and treatment effect of clove volatile oil on motion sickness.
[0037] Test drug
[0038] Clove volatile oil: cloves were purchased from the local Chinese herbal medicine market, and the extraction method was adopted (Li Peng, Zhang Qiongguang, Ding Yingping, Shi Zhaohua, Dai Hongjian. Comparison of different methods for extracting volatile oil from cloves[J]. Chinese Journal of Hospital Pharmacy, 2006(08): 945 -947.) mentioned steam distillation extraction.
[0039] experimental animals
[0040] 160 mice, weighing 18-22g, were purchased from Guangdong Medical Animal Center
[0041] Grouping and Administration
[0042] Experiment is established 8 groups, comprises, normal animal group, blank control group (model group), scopolamine control group, clove oil group (dose is 5mg / kg, 10mg / kg, 50mg / kg, 100mg / kg, 200mg / kg, 500mg ...
Embodiment 2
[0050] The improvement effect of clove volatile oil extracted by different extraction methods of embodiment 2 on mouse motion sickness index
[0051] The purpose of this example is to test whether the clove volatile oil obtained by different extraction methods has a significant difference in the prevention and treatment of motion sickness.
[0052] Test drug
[0053] Clove volatile oil: cloves were purchased from the local Chinese herbal medicine market, and the extraction method was adopted (Li Peng, Zhang Qiongguang, Ding Yingping, Shi Zhaohua, Dai Hongjian. Comparison of different methods for extracting volatile oil from cloves[J]. Chinese Journal of Hospital Pharmacy, 2006(08): 945 -947.) The 6 methods mentioned to extract clove volatile oil.
[0054] experimental animals
[0055] 160 mice, weighing 18-22g, were purchased from Guangdong Medical Animal Center
[0056] Grouping and Administration
[0057] Eight groups were set up in the experiment, including blank contro...
Embodiment 3
[0062] Example 3 The safety test of high-dose clove volatile oil to rats
[0063] The purpose of this example is mainly to initially observe the safety risk of clove volatile oil at higher doses, and to confirm that clove volatile oil has a larger therapeutic window and is feasible for actual clinical use.
[0064] Test drug:
[0065] Clove volatile oil: cloves were purchased from the local Chinese herbal medicine market, and the extraction method was extracted using the method in Example 1.
[0066] experimental method
[0067] The drug preparation method adopts the method in Example 1, and only the concentration of the drug solution is adjusted appropriately. Ready to use every day.
[0068] SD rats, SPF grade, a total of 60 (male) were introduced, and selected after the adaptation period, and the body weight of D0 male mice was 229-245 g.
[0069]
[0070] The appearance, signs, behavioral activities, glandular secretion, respiration, urine and feces properties, and ...
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