Method and system for separately continuous sterilizing carbon source and nitrogen source in bacitracin zinc production

A technology of bacitracin zinc and carbon source, applied in the field of carbon source and nitrogen source separation and continuous sterilization method and system, can solve the problems of high energy consumption, destruction of nutrients in culture medium, etc., reduce energy consumption, relieve cooling pressure, The effect of fermentation unit improvement

Inactive Publication Date: 2019-08-02
山东宝利甾体生物科技有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problems of actual sterilization used in the production of bacitracin zinc in the prior art, high energy consumption, and serious damage to the nutrient components of the culture medium at the first level, the present invention provides a carbon source and nitrogen source separated and connected in the production of bacitracin zinc. Sterilization method and system to solve the above technical problems

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  • Method and system for separately continuous sterilizing carbon source and nitrogen source in bacitracin zinc production

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Embodiment 1

[0035] The invention provides a carbon source and nitrogen source separation and continuous sterilization method in the production of bacitracin zinc, which sequentially includes a system emptying step, a nitrogen source sterilization step, a water sterilization step, a carbon source sterilization step, and a water sterilization step ,Specific steps are as follows:

[0036] (1) System decontamination step: simultaneously decontaminate the fermenter and the continuous sterilization system at 120-140°C and 0.1MPa-0.4MPa for 20-60 minutes.

[0037](2) Carbon source sterilization step: put the pre-prepared carbon source into the continuous sterilization system with a batching pump and maintain it for 1-20 minutes under the conditions of 120-150°C and 0.1MPa-0.5MPa for sterilization, and then quickly The temperature is lowered to 30-40 DEG C, and then enters the fermenter; the carbon source is composed of the following components by weight, 1-3% of glucose, 1-5% of starch, and the ...

Embodiment 2

[0042] A carbon source in the production of bacitracin zinc, nitrogen source separation continuous sterilization method, comprising system empty elimination step, nitrogen source sterilization step, water sterilization step, carbon source sterilization step, water sterilization step, detailed steps are :

[0043] (1) System decontamination step: simultaneously decontaminate the fermenter and the continuous sterilization system at 120-140°C and 0.1MPa-0.4MPa for 20-60 minutes;

[0044] (2) Carbon source sterilization step: inject the material in the pre-prepared carbon source tank into the inlet of the spiral plate heat exchanger Ⅰ through the batching pump, enter the spray heater from the exit of the spiral plate heat exchanger Ⅰ, and then pass through the spray After the heater is heated, it enters the maintenance tank for sterilization, and then enters the heating medium inlet of the spiral plate heat exchanger Ⅰ from the upper end of the maintenance tank to exchange heat wi...

Embodiment 3

[0049] A carbon source and nitrogen source separation and continuous sterilization system in the production of bacitracin zinc, comprising a batching pump 10, the inlet of the batching pump 10 is used to connect the clean water tank 1, the carbon source tank 3, and the nitrogen source tank respectively through pipelines 2. Valves 9 are respectively set between the batching pump 10 and the clean water tank 1, the carbon source tank 3, and the nitrogen source tank 2; the outlet of the batching pump 10 is connected to the inlet 41 of the spiral plate heat exchanger I through a pipeline, and the spiral The outlet 41 of the plate heat exchanger I is connected to the jet heater 6, and the jet heater 6 is connected to the maintenance tank 8, and the outlet of the maintenance tank 8 is connected to the heating medium inlet 44 of the spiral plate heat exchanger I, and the spiral plate heat exchanger I The heating medium outlet 43 of the spiral plate heat exchanger II is connected to the...

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Abstract

The invention belongs to the technical field of bacitracin zinc production and specifically relates to a method and a system for separately continuous sterilizing a carbon source and a nitrogen sourcein bacitracin zinc production. The method comprises the following steps in turn: removing impurities from the space of system; sterilizing the nitrogen source; sterilizing water; sterilizing the carbon source; sterilizing water. A continuous sterilizing technology is adopted by the invention, so that the purposes of separately sterilizing the carbon source and the nitrogen source, reducing loss of nutritional ingredients of culture medium and increasing fermentation unit can be achieved.

Description

technical field [0001] The invention belongs to the technical field of bacitracin zinc production, and specifically relates to a method and system for separating and continuous elimination of carbon and nitrogen sources in the production of bacitracin zinc. Background technique [0002] Bacitracin zinc is light yellow to brown powder; odorless, bitter taste. Soluble in pyridine, almost insoluble in water, methanol, acetone, chloroform or ether, used as feed additive. [0003] At present, practical sterilization is used in the production of bacitracin zinc. The specific operation is to put the prepared medium into a fermenter or other devices, and inject steam to sterilize the medium under pressure. [0004] The existing operation for the actual sterilization of bacitracin zinc has the problems of high energy consumption, and the mixed sterilization of carbon and nitrogen sources seriously destroys the nutrient components of the medium and reduces the fermentation unit. Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/07A61L2/04A61L2/26
CPCA61L2/04A61L2/07A61L2/26
Inventor 张全有张安全
Owner 山东宝利甾体生物科技有限公司
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