Use of chlorophyll derivatives to improve ear microcirculation disorder

A technology of microcirculation disorder and chlorophyll, which is applied in the field of medicine, can solve the problems of high drug prices, ear site treatment efficacy, toxic and side effects, etc., and achieve the effect of wide application, safety, cost-effectiveness and simple process

Active Publication Date: 2022-01-11
武汉联合药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the curative effect, toxic and side effects, and users of the existing drugs for the ear part need to be improved.
In addition, existing medicines are often expensive

Method used

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  • Use of chlorophyll derivatives to improve ear microcirculation disorder
  • Use of chlorophyll derivatives to improve ear microcirculation disorder
  • Use of chlorophyll derivatives to improve ear microcirculation disorder

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] Preparation of reference solution: Accurately weigh 0.143g of spectrally pure ferric oxide dried at 130°C to constant weight, put it in a beaker, add 5ml of hydrochloric acid solution (1→2) to dissolve, transfer to a 100ml measuring bottle, add Add 4ml of hydrochloric acid solution (1→2), add water to the mark, shake well, accurately measure 10ml, put it in a 100ml measuring bottle, add water to the mark, shake well to get a solution containing about 100μg of Fe per 1ml. Accurately measure 0, 0.2, 0.4, 0.6, 0.8 and 1.0ml of the above solutions respectively, put them in a 10ml measuring bottle, add nitric acid solution (1→500) to the mark, shake well, and you get it.

[0045]Preparation of the test solution: Take an appropriate amount of sample, grind it finely, accurately weigh 10mg, put it in a 50ml beaker, add 1.5ml of nitric acid, 3 drops of perchloric acid, cover with a watch glass, heat to nearly dry at 150-160°C, add Nitric acid (1→2) 2ml, cover with a watch glass...

Embodiment 1

[0079] Example 1 Protective effect of silkworm excrement extract on ear acute microcirculation disorder

[0080] According to the above-mentioned method, the iron chlorophyllin sodium weight percent content is about 37.6%, and other chlorophyll derivatives are calculated as iron chlorophyllin (b) for more than 60.0% of the silkworm excrement extract, for its effect on rabbit ear acute microcirculation disorder The role of the test, the results are as follows.

[0081] Table 1 The effect of silkworm excrement extract on the change rate of rabbit ear microcirculation ( n=6)

[0082]

[0083]

[0084] Note: Compared with the negative control group: *: P<0.05, **: P<0.01

[0085] Table 1 shows that compared with the negative control group, the change rate of blood cell aggregation (CMBC) in the high-dose silkworm excrement extract group was significantly reduced (P<0.05), and other assessment indicators in the high-, medium-, and low-dose silkworm excret extract groups we...

Embodiment 2

[0086] Example 2 The protective effect of silkworm excrement extract on acute microcirculation disturbance

[0087] The experiment of Example 1 was repeated, except that the iron chlorophyllin sodium sodium iron chlorophyllate content was about 29.1% by weight, and other chlorophyll derivatives were tested with iron chlorophyllin (b) as the silkworm excrement above 60.0%. The results showed that the blood perfusion (PU), blood cell aggregation (CMBC) and moving blood cell velocity (V) rate of change in the high, middle and low dose groups all decreased, indicating that the ear microcirculation disorder of the tested rabbits was improved.

[0088] As can be seen from the above examples, sodium ferric chlorophyllin and chlorophyll derivatives containing sodium ferric chlorophyllin (such as silkworm excrement) can effectively improve or regulate blood perfusion, concentration of moving blood cells and speed of moving blood cells, thereby improving ear Acute microcirculation disor...

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Abstract

The invention belongs to the field of medicine, and relates to the use of chlorophyll derivatives for improving ear microcirculation disorders, in particular to the use of chlorophyll derivatives in preparing medicines for treating and / or preventing ear microcirculation disorders. The chlorophyll derivatives of the present invention, such as chlorophyll extracts and silkworm excrement extracts, have good curative effects on improving ear microcirculation disorders. The chlorophyll derivatives can also comprehensively prevent and improve ear microcirculation disturbance by acting in multiple links. Moreover, the toxic and side effects of the chlorophyll derivatives are improved, the applicable population is wide and safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, the preparation method of the chlorophyll derivative and the process applied to the preparation of medicine are relatively simple, and the cost is effectively controlled.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the use of chlorophyll derivatives for improving ear microcirculation disturbance. Background technique [0002] With the improvement of people's living standards, the improvement of diet structure, the change of lifestyle, and the influence of genetic factors, the incidence of microcirculation disorders is on the rise. The high prevalence and high recurrence rate are the main causes of microcirculation disorders. main feature. Microcirculation is very sensitive to various pathogenic factors, such as physical, chemical and biological stimuli. Under the action of pathogenic factors, pathological changes in local or systemic microcirculation may occur. For example, if the microcirculation function is impaired, it will not be able to meet the needs of tissue cells for oxygen and nutrient metabolism, directly affecting the physiological functions of various organs. Such conditions are known a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/409C07D487/22A61P27/16
CPCA61K31/409C07D487/22A61P27/16
Inventor 刘朝胜罗京吴瑜付雯刘敏余明森王根才周红晖袁建新徐发新
Owner 武汉联合药业有限责任公司
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