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Polyvinyl alcohol crosslinked hyaluronic acid gel and preparation method thereof

A technology of hyaluronic acid and polyvinyl alcohol, applied in the field of polyvinyl alcohol-crosslinked hyaluronic acid gel and its preparation, can solve the problems of insufficient transparency, reduced purity, hidden safety hazards and the like, and achieve high purity and less impurities , the effect of low impurities

Inactive Publication Date: 2019-08-06
无锡元旭生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies in the above prior art, the present invention provides polyvinyl alcohol cross-linked hyaluronic acid gel and its preparation method, the purpose is to solve the problem in the prior art that cross-linked hyaluronic acid needs to be used Linking agents and organic solvents lead to one or more residues of organic solvents, oil phase substances, surfactants and cross-linking agents in the final cross-linked hyaluronic acid product, resulting in reduced purity, insufficient transparency, and technical problems of potential safety hazards

Method used

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  • Polyvinyl alcohol crosslinked hyaluronic acid gel and preparation method thereof

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Embodiment 1

[0024] The present embodiment provides the preparation method of polyvinyl alcohol cross-linked hyaluronic acid gel, comprising the following steps:

[0025] S1, dissolving polyvinyl alcohol in water to obtain a polyvinyl alcohol solution, the mass fraction of the polyvinyl alcohol solution is 50%, wherein the molecular weight of hyaluronic acid is 20,000 Daltons;

[0026] S2, dissolving hyaluronic acid in water to obtain a hyaluronic acid solution, the mass fraction of the hyaluronic acid solution is 1%, and the molecular weight of polyvinyl alcohol is 2 million Daltons;

[0027] S3, adding the polyvinyl alcohol solution in step S1 to the hyaluronic acid solution in step S2, stirring and mixing according to the mass ratio of the hyaluronic acid solution and the polyvinyl alcohol solution being 1:1, to obtain a mixed solution;

[0028] S4, after sealing the mixed solution in step S3, put it into freezing treatment at 0° C. for 24 hours, and then put it into room temperature fo...

Embodiment 2

[0033] The present embodiment provides the preparation method of polyvinyl alcohol cross-linked hyaluronic acid gel, comprising the following steps:

[0034] S1, dissolving polyvinyl alcohol in water to obtain a polyvinyl alcohol solution, the mass fraction of the polyvinyl alcohol solution is 2%, wherein the molecular weight of hyaluronic acid is 10,000 Daltons;

[0035] S2, dissolving hyaluronic acid in water to obtain a hyaluronic acid solution, the mass fraction of the hyaluronic acid solution is 30%, wherein the molecular weight of polyvinyl alcohol is 300,000 Daltons;

[0036] S3, adding the polyvinyl alcohol solution in step S1 to the hyaluronic acid solution in step S2, stirring and mixing according to the mass ratio of the hyaluronic acid solution and the polyvinyl alcohol solution being 100:1, to obtain a mixed solution;

[0037] S4, after sealing the mixed solution in step S3, put it into freezing treatment at -60°C for 1 hour, and then put it into room temperature ...

Embodiment 3

[0042] The present embodiment provides the preparation method of polyvinyl alcohol cross-linked hyaluronic acid gel, comprising the following steps:

[0043] S1, dissolving polyvinyl alcohol in water to obtain a polyvinyl alcohol solution, the mass fraction of the polyvinyl alcohol solution is 25%, wherein the molecular weight of hyaluronic acid is 150,000 daltons;

[0044] S2, dissolving hyaluronic acid in water to obtain a hyaluronic acid solution, the mass fraction of the hyaluronic acid solution is 15%, wherein the molecular weight of polyvinyl alcohol is 1 million Daltons;

[0045] S3, adding the polyvinyl alcohol solution in step S1 to the hyaluronic acid solution in step S2, stirring and mixing according to the mass ratio of the hyaluronic acid solution and the polyvinyl alcohol solution being 50:1, to obtain a mixed solution;

[0046] S4, after sealing the mixed solution in step S3, put it into freezing treatment at -30°C for 12 hours, and then put it into room tempera...

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Abstract

The invention belongs to the technical field of hyaluronic acid gel preparation, in particular to a preparation method of a polyvinyl alcohol crosslinked hyaluronic acid gel, and the preparation method comprises the following steps: S1, preparing a polyvinyl alcohol solution; S2, preparing a hyaluronic acid solution; S3, adding the polyvinyl alcohol solution into the hyaluronic acid solution, stirring and mixing uniformly; S4, freezing and thawing the mixed solution; S5, repeating the step S4 for many times; and S6, obtaining the polyvinyl alcohol crosslinked hyaluronic acid gel after cleaning. The invention also provides the polyvinyl alcohol cross-linked hyaluronic acid gel prepared according to the method, the polyvinyl alcohol cross-linked hyaluronic acid gel has high purity and transparency, can be used for producing medical or preventive products, is used for injection, tissue repair and tissue enhancement of animals, especially human beings, has good biocompatibility and degradability, and is clinically safe.

Description

technical field [0001] The invention belongs to the technical field of hyaluronic acid gel preparation, and in particular relates to polyvinyl alcohol-crosslinked hyaluronic acid gel and a preparation method thereof. Background technique [0002] Hyaluronic acid is a linear polymer polysaccharide in which β-D-N-acetylglucosamine and β-D-glucuronic acid are combined with each other. The distribution of hyaluronic acid in the human body has superior biocompatibility. For example, moisturizing effect, for example, exerts many medicinal effects, so it is attracting attention as a natural material in the fields of medicine and beauty. Also, hyaluronic acid gel has excellent handling properties and is a very useful material in the medical and cosmetic fields. Generally, hyaluronic acid needs to be chemically modified to prepare a cross-linked hyaluronic acid gel. [0003] Polyvinyl alcohol (PVA) is a widely used water-soluble polymer material. It has good film-forming, emulsify...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L29/04C08J3/075C08J3/24
CPCC08J3/075C08J3/24C08J2305/08C08J2329/04C08J2405/08C08J2429/04
Inventor 杨淑艳赵科研郭文平
Owner 无锡元旭生物技术有限公司
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