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Panax ginseng stem leaf effective parts, extracting method thereof and application of panax ginseng stem leaf effective parts in lowering blood glucose

A technology of ginseng stems and leaves and effective parts, which is applied in the field of hypoglycemic application, effective parts of ginseng stems and leaves and its extraction, can solve the problems of unclear active ingredients of ginseng stems and leaves, general effect, and unknown hypoglycemic mechanism, and achieve great promotion Application value, reducing glucose tolerance, effect of small dosage

Pending Publication Date: 2019-08-09
上海复浩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problems in the prior art that the active ingredients of ginseng stems and leaves are unclear, the mechanism of hypoglycemia is unclear, and the effect is general.

Method used

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  • Panax ginseng stem leaf effective parts, extracting method thereof and application of panax ginseng stem leaf effective parts in lowering blood glucose
  • Panax ginseng stem leaf effective parts, extracting method thereof and application of panax ginseng stem leaf effective parts in lowering blood glucose
  • Panax ginseng stem leaf effective parts, extracting method thereof and application of panax ginseng stem leaf effective parts in lowering blood glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Take 2 kg of dried ginseng stems and leaves (purchased from the medicinal material wholesale market), extract them twice with 60 L and 20 L of ethanol aqueous solution with a concentration of 30% at 50°C, for the first time for 1 hour, and for the second time After 1 hour of extraction, the two extracts were combined and filtered with filter paper, and the filtrate was collected and concentrated under reduced pressure at 50°C to obtain 5L ginseng stem and leaf extract. The filter paper type is not limited.

[0039] (2) Get the ginseng stem and leaf extract obtained in step (1), centrifuge to get the supernatant, put on the pretreated D101 macroporous adsorption resin, the resin column volume is 9L, wash 5 column volumes with water first, and then use 70% Ethanol aqueous solution was used to desorb ginsenosides to obtain 27 L of desorption liquid, which was concentrated under reduced pressure at 65° C. to 6 L of aqueous solution.

[0040] (3) Take the 6L concentrate...

Embodiment 2

[0043] (1) Take 1.5 kg of dried ginseng stems and leaves (purchased from the medicinal materials wholesale market), and use 60 L and 45 L of ethanol concentration of 90% aqueous solution to extract twice at 90 ° C, the first time for 3 hours, and the second time After 3 hours of extraction, the two extracts were combined and filtered through filter paper, and the filtrate was collected and concentrated under reduced pressure at 65°C to obtain 5L ginseng stem and leaf extract.

[0044] (2) Get the ginseng stem and leaf extract obtained in step (1), centrifuge to get the supernatant, put on the pretreated AB-8 macroporous adsorption resin, the volume of the resin column is 7L, wash 5 column volumes with water first, and then use Desorb ginsenosides with 70% ethanol aqueous solution to obtain 21 L of stripping solution, which was concentrated under reduced pressure at 65° C. to 4 L of aqueous solution.

[0045] (3) Take the 4L concentrated aqueous solution obtained in step (2) an...

Embodiment 3

[0049] (1) Take 2 kg of dried ginseng stems and leaves (purchased from the medicinal materials wholesale market), and use 60 L and 20 L of ethanol aqueous solution with a concentration of 75% to extract twice at 75 ° C, the first time for 3 hours, and the second time After 2 hours of extraction, the two extracts were combined and filtered with filter paper, and the filtrate was collected and concentrated under reduced pressure at 65°C to obtain 3L ginseng stem and leaf extract.

[0050] (2) Get the ginseng stem and leaf extract obtained in step (1), centrifuge to get the supernatant, put on the pretreated D101 macroporous adsorption resin, the resin column volume is 9L, wash 5 column volumes with water first, and then use 70% Ethanol aqueous solution was used to desorb ginsenosides to obtain 27 L of desorption solution, which was concentrated under reduced pressure at 65° C. to obtain 6.3 L of aqueous solution.

[0051] (3) Take the 6.3L aqueous solution obtained in step (2) a...

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Abstract

The invention discloses panax ginseng stem leaf effective parts, an extracting method thereof and application of the panax ginseng stem leaf effective parts in lowering the blood glucose, and belongsto the field of drugs. The panax ginseng stem leaf effective parts comprise, by mass, 1-30% of ginsenoside Rg1, 10-40% of ginsenoside Re, 1-20% of ginsenoside Rb2 and 1-30% of ginsenoside Rd. The invention further discloses the extracting method of the panax ginseng stem leaf effective parts and the application of the panax ginseng stem leaf effective parts in treating diabetes. The panax ginsengstem leaf effective parts can correct glucose metabolic disorders, lower fasting blood glucose, reduce impaired glucose tolerance, improve insulin resistance and insulin sensitivity, and have the function of treating or preventing diabetes and complications of the diabetes.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to an effective part of ginseng stems and leaves, an extraction method thereof and an application for lowering blood sugar. Background technique [0002] According to the latest statistics from IDF, as of 2018, the incidence of diabetes in Chinese adults was 11.6%, and the number reached 114 million, ranking first in the world, of which type 2 diabetes accounted for 90% and type 1 diabetes accounted for 5%. Potential diabetes and impaired glucose tolerance patients are as high as 50%, about 500 million people. In recent years, diabetes has shown a trend of rejuvenation, high growth, high morbidity, and rising mortality, which will definitely bring a heavy economic burden to the society. For the current drug treatment of diabetic patients, type 1 diabetes is an absolute deficiency of insulin secretion, and patients can only be treated with insulin replacement. From the curren...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P3/10A61P5/50A61K135/00
CPCA61K36/258A61K2236/333A61K2236/39A61K2236/55A61P3/10A61P5/50
Inventor 周平滕宝松杨宏杰
Owner 上海复浩生物科技有限公司
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