A kind of preparation method of embedding resveratrol
A technology of adding resveratrol and methanol is applied in the field of composite materials, which can solve the problems of unsuitability for large-scale industrial production and many application restrictions, and achieve the effects of good performance, improved absorption and utilization rate in the body, and good slow-release effect.
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Embodiment 1
[0024] (1) Preparation of carboxymethyl-β-cyclodextrin
[0025] Pipette an appropriate amount of sodium hydroxide solution with a concentration of 25% in a round-bottomed flask, add a certain amount of β-CD (β-cyclodextrin), and stir to dissolve it completely. A certain amount of chloroacetic acid aqueous solution was added dropwise to the alkaline solution of β-CD under stirring, and the reaction was carried out at room temperature for 9 h. After the reaction is completed, neutralize with dilute hydrochloric acid, adjust the pH value of the system to 9, then add 80 mL of methanol until the system no longer has a white precipitate, leave it for 12 hours, filter, and add water to dissolve the precipitate (precipitation and water are maintained at 1:1), To this solution was added methanol until no more precipitate formed, filtered and dried in vacuo at 80°C.
[0026] (2) Preparation of carboxymethyl-β-cyclodextrin chitosan hydrochloride nanoparticles
[0027] Prepare a 1 mg / mL...
Embodiment 2
[0031] (1) Preparation of carboxymethyl-β-cyclodextrin
[0032] Pipette an appropriate amount of sodium hydroxide solution with a concentration of 25% by mass into a round-bottomed flask, add a certain amount of β-CD, and stir with warming to dissolve it completely. A certain amount of chloroacetic acid aqueous solution was added dropwise to the alkaline solution of β-CD under stirring, and the reaction was carried out at room temperature for 9 h. After the reaction is completed, neutralize with dilute hydrochloric acid, adjust the pH of the system to 9, then add 80 mL of methanol until the system no longer has a white precipitate, leave it for 12 hours, filter, add water to dissolve the precipitate (the amount of precipitate and water is kept at 1:1), add to the solution. Methanol was added to this solution until no more precipitation occurred, filtered and dried under vacuum at 80°C.
[0033] (2) Preparation of carboxymethyl-β-cyclodextrin chitosan hydrochloride nanoparticl...
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