Method capable of simultaneously preparing avermectin B2a fine powder and ointment

A technology of abamectin and refined powder is applied in the field of simultaneously preparing abamectin B2a refined powder and ointment, which can solve the problems of lack of drug efficacy and the like, and achieve the effect of expanding the industrial chain

Inactive Publication Date: 2019-08-09
江苏物网慧农科技集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditionally produced B1 fine powder and B1 ointment have a broad spectrum of insecticidal properties, but the B2 component is specific to nematodes and has a medicinal effect that B1a does not have

Method used

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  • Method capable of simultaneously preparing avermectin B2a fine powder and ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] like figure 1 Shown, a kind of method that can prepare Abamectin B2a fine powder and ointment simultaneously, comprises the steps:

[0025] (a) Abamectin B1a crystallization mother liquor is concentrated and desolvated: the abamectin B1a crystallization mother liquor is evaporated under reduced pressure to obtain a concentrate, and toluene is added to the concentrate and heated to 83° C. and stirred for 35 minutes to fully dissolve, and the extraction is obtained. Liquid, wherein, the volume ratio of the added amount of toluene to the concentrate is 2.8:1;

[0026] (b) Washing with water: add 83°C hot water with 28% volume of the extract, stir for 33 minutes, let stand for 1.5 hours, remove the water phase and emulsion phase, and obtain the extract after washing;

[0027] (c) Cooling crystallization and centrifugation: cooling the washed extract to 3° C. in a circulating water bath and maintaining it for 3 hours; using a centrifuge to centrifuge in a closed manner to o...

Embodiment 2

[0032] like figure 1 Shown, a kind of method that can prepare Abamectin B2a fine powder and ointment simultaneously, comprises the steps:

[0033] (a) Abamectin B1a crystallization mother liquor is concentrated and desolventized: Abamectin B1a crystallization mother liquor is evaporated and desolvated under reduced pressure to obtain a concentrate, and toluene is added to the concentrate and heated to 80° C. and stirred for 30 minutes to fully dissolve to obtain an extraction Liquid, wherein, the volume ratio of the added amount of toluene to the concentrate is 2.5:1;

[0034] (b) Washing: add 80°C hot water with 25% volume of the extract, stir for 30 minutes, let stand for 1 hour, remove the water phase and the milk phase, and obtain the extract after washing;

[0035] (c) Cooling crystallization and centrifugation: cooling the washed extract to 0° C. in a circulating water bath and maintaining it for 2 hours; centrifuging in a centrifuge to obtain primary coarse crystals of...

Embodiment 3

[0040] like figure 1 Shown, a kind of method that can prepare Abamectin B2a fine powder and ointment simultaneously, comprises the steps:

[0041] (a) Abamectin B1a crystallization mother liquor is concentrated and desolventized: the abamectin B1a crystallization mother liquor is evaporated under reduced pressure to obtain a concentrate, and toluene is added to the concentrate and heated to 85° C. and stirred for 45 minutes to fully dissolve, and the extraction is obtained. Liquid, wherein, the volume ratio of the added amount of toluene to the concentrate is 3.0:1;

[0042] (b) washing with water: adding 85°C hot water with 30% volume of the extract, stirring for 35 minutes, standing for 2 hours, removing the water phase and the milk phase, and obtaining the extract after washing;

[0043] (c) Cooling crystallization and centrifugation: cooling the washed extract to 5° C. in a circulating water bath and maintaining it for 4 hours; using a centrifuge to centrifuge in a sealed...

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Abstract

The invention discloses a method capable of simultaneously preparing avermectin B2a fine powder and ointment. The method includes the steps of avermectin B1a crystallized mother liquor concentrating and solvent removal, water washing, cooling crystallization, centrifugation, avermectin B2a fine powder preparation, recrystallized mother liquor vacuum evaporation and solvent removal, methanol addingfor adjustment to obtain B2a ointment and the like. According to the method, by studying the B2a component, screening solvents and optimizing the production process, the B2a component fine powder isextracted and the B2a ointment is obtained; due to the fact that the B2a component is extracted from a B1a extraction by-product, the method can expand the avermectin industrial chain.

Description

technical field [0001] The invention relates to the technical field of pesticide preparation, in particular to a method capable of simultaneously preparing abamectin B2a fine powder and ointment. Background technique [0002] Abamectin, the English name Avermectins, is a class of sixteen-membered macrolide compounds with insecticidal, acaricidal, and nematicidal activities first developed by Satoshi Omura of Kitasato University in Japan and Merck Corporation of the United States. It was produced from Streptomyces Produced by fermentation of Streptomyces avermitilis. Consisting of 8 homologues, B1 and B2 are two of the higher proportions among the shuffled homologues. Traditionally produced B1 fine powder and B1 ointment have a broad spectrum of insecticidal properties, but the B2 component is specific to nematodes and has a medicinal effect that B1a does not have. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06A01N43/90A01N25/04A01N25/12A01P7/04A01P7/02A01P5/00
CPCC07H17/08C07H1/06A01N43/90A01N25/04A01N25/12
Inventor 刘文彬赵欣郭炜
Owner 江苏物网慧农科技集团有限公司
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