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Medical suture line and preparation method thereof

A technology of sutures and compounds, applied in pharmaceutical formula, medical science, coatings, etc., can solve problems such as no curative effect, drug shedding, affecting suture strength, etc., and achieve the effect of improving therapeutic effect, sustained release, and increasing gene concentration

Pending Publication Date: 2019-08-16
AFFILIATED HOSPITAL OF NANTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing drug-loaded sutures mainly load the drug onto the surface of the suture by direct dipping. However, we found after our research that some tissues, especially tendon tissue, are relatively dense when suturing. It is easy to fall off due to resistance, and the drug cannot be delivered into the tissue with the suture, and the treatment effect is very poor, basically no curative effect
There are also studies by directly preparing the drug into the suture, but this will definitely affect the strength of the suture, especially for some tissues that require a certain suture strength, this kind of suture is difficult to meet the requirements

Method used

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  • Medical suture line and preparation method thereof
  • Medical suture line and preparation method thereof
  • Medical suture line and preparation method thereof

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preparation example Construction

[0045] A kind of preparation method of medical suture, comprises the following steps:

[0046] a), dissolving the dopamine monomer in a weakly alkaline solution to obtain a dopamine solution;

[0047] b) Soak the suture body 1 in the dopamine solution to obtain a polydopamine-modified suture;

[0048] c) Putting the polydopamine-modified suture into the gene-carrying nanoparticle solution to obtain the polydopamine-modified gene-carrying nanoparticle suture.

[0049] In the preparation method, firstly, the dopamine is dissolved in a weak alkaline solution with a pH value of 8.0-8.9. Wherein, the weak alkaline solution includes but not limited to Tris-HCl, PBS, ammonia water, sodium hydroxide and other solutions.

[0050] In this preparation method, the concentration of the dopamine solution is preferably 0.1-8 mg / mL, more preferably 1-4 mg / mL, specifically 3 mg / mL; the Tris-HCl concentration is preferably 0.01-1 M, specifically can be The choice is 0.05M; the pH value of th...

specific Embodiment

[0084] Preparation of polydopamine-modified sutures

[0085] step 1)

[0086] Weigh 1.21g of Tris (Tris, Mw=121.14) and add it to 1000mL of double-distilled water. After fully dissolving, adjust the pH value to about 8.5 with hydrochloric acid to prepare a 0.01M Tris-HCl weak alkaline solution.

[0087] Step 2)

[0088] Weigh 100mg of dopamine (Dopamine, Mw=153) and add it to the 100mL Tris-HCl solution configured in step 1). After fully dissolving, a 1mg / mL dopamine solution is obtained, and then the PDSII of the surgical suture Ethicon is immersed in the dopamine solution. And stir slowly at room temperature to make dopamine oxidize and self-polymerize, about 2-4 hours, a layer of polydopamine coating is formed on the surface of the suture, such as figure 1 as shown, figure 2 PDSII sutures coated with polydopamine compared with ordinary sutures.

[0089] Preparation of Gene-Loaded Nanoparticles

[0090] step 1)

[0091] Weigh 20 mg of PLGA (lactide:glycolide=65:35 (n:...

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Abstract

The invention discloses a medical suture line and a preparation method thereof. The suture line comprises a suture line body, an adhesive coating layer and a drug-loaded layer. The suture line body isimmersed in an adhesive to form the adhesive coating layer on the surface, and then a line with the adhesive coating layer is immersed in drug-loaded nanoparticles, so that the drug-loaded nanoparticles can be adsorbed on the adhesive coating layer to form a drug-loaded layer, and the multi-layer drug-loaded layer can be formed by repeated immersion. The medical suture line can greatly improve the adsorptive force of the drug-loaded nanoparticles attached onto the line, and the suture line can uniformly slowly release a drug after use.

Description

technical field [0001] The invention relates to a medical suture and a preparation method thereof, in particular to a drug-loaded medical suture and a preparation method thereof. Background technique [0002] Tissue damage caused by diseases and accidents is very common in clinical practice. How to promote tissue regeneration and repair is still a common problem in surgery, especially for tissues that are difficult to heal, such as tendon tissue, or tissues of diabetic patients. At present, the main method is to increase the strength of surgical suture, improve suture materials and methods, etc., but the effect is limited. Some studies have injected genes that promote healing into damaged tissues. However, due to the small amount of injection, it is easy to leak and cannot achieve continuous supply. At the same time, the injected genes are easily degraded by enzymes in the tissue, resulting in mediocre therapeutic effects. [0003] To this end, we plan to load the previousl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/00A61L17/10A61L17/14A61B17/06
CPCA61L17/145A61L17/10A61L17/005A61B17/06166A61L2300/258A61L2300/624A61L2300/412A61L2300/404C08L77/04C08L89/00
Inventor 周友浪汤锦波张鲁中杨纤纤
Owner AFFILIATED HOSPITAL OF NANTONG UNIV
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