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Hydrophobic coating, preparation method thereof, application thereof and absorbable implantable device

A hydrophobic coating and implantable technology, applied in the field of absorbable implantable devices and hydrophobic coatings, can solve the problems of difficulty in use, limitation, and reduce the degradation rate of degradable matrix materials, so as to improve porosity and delay degradation. Effect

Active Publication Date: 2019-08-16
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, most of the existing published patents use coatings based on inorganic materials to reduce the degradation rate of degradable matrix materials, and inorganic material coatings are often brittle, so they are only suitable for orthopedic implants. It is difficult to use degradable cardiovascular stents and cerebrovascular stents with high requirements; in addition, the inorganic material coatings in the published patents have special requirements for the preparation process and matrix materials, which are limited to magnesium and magnesium alloy materials. deal with

Method used

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  • Hydrophobic coating, preparation method thereof, application thereof and absorbable implantable device
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  • Hydrophobic coating, preparation method thereof, application thereof and absorbable implantable device

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preparation example Construction

[0068] The preparation method of the hydrophobic coating of an embodiment, comprises the steps:

[0069] Step 110: providing a hydrophobic monomer, which is a block copolymer comprising a hydrophobic block, a degradable block and a cross-linking functional group.

[0070] The hydrophobic monomer is the same as above, and will not be repeated here.

[0071] In one embodiment, the following method is used to prepare hydrophobic monomers:

[0072] Use a polymer containing terminal hydroxyl groups to form a hydrophobic block (that is, A-OH, both ends contain hydroxyl groups, the following expressions represent the same meaning, and will not be described in detail below) as an initiator to synthesize a hydrophobic block containing terminal hydroxyl groups And the polymer of the degradable block (ie B-A-B-OH), and then use acryloyl chloride to react with the terminal hydroxyl group of the polymer containing the hydrophobic block and the degradable block at the end to obtain the hyd...

Embodiment 20～ Embodiment 24

[0113] Embodiment 20~embodiment 24 and comparative example 1~comparative example 4 adopt following test method:

[0114] In vivo sample metal weight loss measurement method: the absorbable implantable device is implanted in the animal body for a period of time, and then the animal is sacrificed, and the absorbable implantable device is taken out. Micro-CT with a resolution of 5 μm was used for high-resolution scanning, and the results were processed to calculate the volume of undegraded metal, so as to calculate weight loss=1-volume of undegraded metal / initial metal volume.

[0115] Table 1 Embodiment 1-19 hydrophobic coating components

[0116]

[0117]

Embodiment 1

[0119] Cut a pure iron sheet with a thickness of 200 μm (purity >99.9%) into 22mm×26mm, polish it with 800, 1500, 2000, and 3000 mesh sandpaper in sequence, and put the polished iron sheet in acetone and absolute ethanol for ultrasonic cleaning in sequence 10min, then dry the surface of the iron sheet with nitrogen, and place the iron sheet in an oven at 60°C to fully dry.

[0120] Dissolve polylactic acid (PLA) with a molecular weight of 60,000 in ethyl acetate to prepare a polylactic acid solution with a concentration of 0.01 g / mL. The polylactic acid solution was sprayed on the surface of the treated iron sheet by an ultrasonic spraying method to prepare an iron sheet with a PLA coating on the surface with a thickness of 4 μm. During the spraying process, the flow rate of the pump liquid is 0.1mL / min, and the ultrasonic power is 5.0W. Place the PLA-coated iron sheet in a fume hood to fully evaporate the ethyl acetate solvent.

[0121] With reference to the method in the a...

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Abstract

The invention relates to a hydrophobic coating, a preparation method thereof, an application thereof and an absorbable implantable device. The hydrophobic coating is the coating formed by cross-linking of hydrophobic monomers, and the hydrophobic monomer is a segmented copolymer comprising a hydrophobic block, a degradable block, and a cross-linking functional group. When the hydrophobic coating provided by the invention covers the surface of a degradable material, the hydrophobic block enables the hydrophobic coating to function as a good water-resisting effect at an early stage, so that thedegradable material hardly degrades; in the later stage, the degradable block is degraded, and the porosity of the hydrophobic coating is increased, so that the body fluid can contact the degradable matrix material through the pores of the hydrophobic coating to promote the degradation of the matrix material.

Description

technical field [0001] The invention belongs to the technical field of degradable materials, and in particular relates to a hydrophobic coating, its preparation method, application and absorbable implantable device. Background technique [0002] In the medical field, degradable materials can be degraded and absorbed by the body after serving in the body, which can avoid the negative effects caused by secondary surgical removal and long-term existence of materials, so they are widely used in orthopedic internal fixation, drug slow and controlled release carriers, Tissue engineering stents, cardiovascular stents and other fields. [0003] The degradation rate and mechanical properties of degradable materials are two important properties that are concerned when they are applied clinically. Ideal implantable devices (such as degradable vascular stents, absorbable bone plates, bone nails, etc.) usually need to maintain good mechanical support for a period of time in the early st...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/10A61L31/14A61L17/10A61L17/14
CPCA61L17/10A61L17/145A61L31/06A61L31/10A61L31/146A61L31/148A61L2420/02A61L2420/08
Inventor 丁建东齐永丽李昕何垚李佩泽
Owner FUDAN UNIV
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