Salvia extract nanocrystal self-stabilizing pickering emulsion and preparation method thereof

An extract and nanocrystal technology, applied in the field of Salvia miltiorrhiza extract nanocrystal self-stabilizing Pickering emulsion and its preparation, can solve the problems of complex extract components, limiting the drug-carrying capacity of the emulsion, etc.

Active Publication Date: 2021-07-09
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Pickering emulsions may still have the following two problems: ①Pickering emulsions mostly use silica nanoparticles as solid particles to stabilize emulsion droplets when administered orally, and there are potential safety problems; ②Drugs are mainly dissolved in the oil phase, The solubility of the oil phase directly limits the drug loading capacity of the emulsion
However, the inventor's research group has always used monomer compounds as raw materials to prepare nanocrystalline self-stabilizing Pickering emulsions, and has not yet applied this new drug nanocrystalline self-stabilizing Pickering emulsion preparation to traditional Chinese medicine extracts with complex components.
Compared with the monomer, the composition of the extract is complex, often containing a variety of water-soluble components and insoluble components, as well as macromolecular impurities such as proteins and polysaccharides; neither the extract nanocrystal suspension nor its Pickering emulsion has been reported

Method used

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  • Salvia extract nanocrystal self-stabilizing pickering emulsion and preparation method thereof
  • Salvia extract nanocrystal self-stabilizing pickering emulsion and preparation method thereof
  • Salvia extract nanocrystal self-stabilizing pickering emulsion and preparation method thereof

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preparation example Construction

[0041] The preparation method of the Danshen extract nanocrystal self-stabilizing Pickering emulsion of the present invention comprises the following steps:

[0042] A. Prepare the primary suspension: dissolve the salvia miltiorrhiza extract in an organic solvent, add it into water with a pH value of 9-13 under stirring, continue heating and stirring to evaporate the organic solvent, and obtain the primary suspension A;

[0043] B. Preparation of nanocrystal suspension: Homogenize the primary suspension A obtained in step A to obtain nanocrystal suspension B through high-pressure homogenization;

[0044] C. Preparation of nanocrystalline self-stabilizing Pickering emulsion: the nanocrystalline suspension B obtained in step B is mixed with oil phase macrogol glycerol oleate, and homogenized under high pressure to obtain nanocrystalline self-stabilizing Pickering emulsion of Salvia miltiorrhiza extract.

[0045] In the above-mentioned preparation method:

[0046] The organic so...

Embodiment 1

[0140] The preparation method of embodiment 1 salvia miltiorrhiza extract nanocrystal self-stabilizing Pickering emulsion, comprises the following steps:

[0141] (1) Weigh 80 mg of the salvia miltiorrhiza extract raw material, add it to 5 mL of ethanol, shake it in a constant temperature water bath at 50 ° C for 4 hours, pour it into 40 ml of pure water with an initial pH value of 9, stir and evaporate the ethanol at 60 ° C, and obtain the primary suspension A ;

[0142] (2) The primary suspension A is homogeneously circulated 10 times under the condition of 600bar to prepare the nanocrystal suspension B;

[0143] (3) Mix the prepared nanocrystal suspension B with 4ml of the mixed oil phase (baldwood volatile oil: polyethylene glycol oleic acid glyceride = 2:1), and then use a high-pressure homogenizer to circulate under the condition of 600bar 10 times, a self-stable Pickering emulsion formulation can be prepared.

[0144] The particle size was detected by photon correlati...

Embodiment 2

[0145] The preparation method of embodiment 2 Danshen extract nanocrystal self-stabilizing Pickering emulsion, comprises the following steps:

[0146] (1) Weigh 160mg of salvia miltiorrhiza extract raw material drug, add 5ml of acetone: ethanol (1:1) mixed solvent, oscillate in a constant temperature water bath at 50°C for 4h, inject into 40ml of pure water with an initial pH value of 9, stir and evaporate at 60°C Remove the organic solvent to obtain primary suspension A;

[0147] (2) The primary suspension A is homogeneously circulated 20 times under the condition of 800bar to prepare the nanocrystal suspension B;

[0148] (3) Mix the prepared nanocrystal suspension B with 4ml of mixed oil phase (balm balm volatile oil: macrogol glycerol oleate=1:2), and then use a high-pressure homogenizer to circulate at 800bar After 20 times, a self-stable Pickering emulsion formulation can be obtained.

[0149] The particle size was detected by photon correlation spectroscopy (PCS), and...

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Abstract

The invention belongs to the field of preparations, and in particular relates to a nano-crystal self-stabilizing Pickering emulsion of salvia miltiorrhiza extract and a preparation method thereof. In the present invention, the content of salvianolic acid B is 60-100 mg / g, the content of danshensu is 3-10 mg / g, the content of rosmarinic acid is 3-10 mg / g; the content of tanshinone II A is 5-20 mg / g, the content of cryptotanshinone is 2-10mg / g, and the content of tanshinone I is 3-10mg / g. Salvia miltiorrhiza extract is the raw material drug, and the oil-in-water type Pickering emulsion made with oil phase and water phase, this The invention is a nanocrystalline self-stabilizing Pickering emulsion with stable properties prepared by taking the Danshen extract containing both the water-soluble and insoluble medicinal ingredients of Danshen as the raw material drug, in which the distribution of water-soluble ingredients such as salvianolic acid B In the water phase, some insoluble components such as tanshinone are distributed in the oil phase, and some are adsorbed on the emulsion droplet interface to stabilize the emulsion.

Description

technical field [0001] The invention belongs to the field of preparations, and in particular relates to a nano-crystal self-stabilizing Pickering emulsion of salvia miltiorrhiza extract and a preparation method thereof. Background technique [0002] Pickering emulsions are emulsions that are stabilized by adsorption of solid particles at the oil-water interface, forming a film structure. There are three main types of solid particles used: ① Inorganic salts, such as silicon dioxide, clay, ferric oxide, etc.; ② Nano-synthetic materials, such as carbon nanotubes, nanosheets, gold nanoparticles-graphene oxide hybrids, etc. ; ③ biodegradable materials, such as starch, cellulose, soybean protein, fat, chitosan and so on. Compared with traditional emulsions, Pickering emulsions do not require the use of surfactants, have better safety, and have better stability against mergers. They are a potentially excellent drug delivery system and have been used for oral administration. For e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/14A61K9/107A61K36/537A61P9/00A61K36/48
CPCA61K9/107A61K36/48A61K36/537A61K47/14A61P9/00A61K2300/00
Inventor 张继芬徐晓玉张焦王帆
Owner SOUTHWEST UNIV
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