Ligament bracket, shaping method of ligament bracket, and ligament implanting materials formed from ligament bracket

A ligament and biological technology, applied in the field of medical tissue engineering scaffold manufacturing, can solve the problems of difficult and rapid large-scale preparation, low mechanical strength of ligament scaffolds, etc. Effect

Inactive Publication Date: 2019-08-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem solved by the present invention is: the mechanical strength of the ligament bracket composed of electrospun nanofibers is low, and it is difficult to prepare rapidly and on a large scale

Method used

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  • Ligament bracket, shaping method of ligament bracket, and ligament implanting materials formed from ligament bracket
  • Ligament bracket, shaping method of ligament bracket, and ligament implanting materials formed from ligament bracket
  • Ligament bracket, shaping method of ligament bracket, and ligament implanting materials formed from ligament bracket

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Embodiment 1

[0025] Figure 1 to Figure 7 A first embodiment of the invention is shown. in, figure 1 A ligament support 6 of the present embodiment is shown, which is used for a cruciate ligament support. The ligament support 6 is a core-sheath composite structure, wherein the core is a USP2-0PDSII biodegradable suture 1 with a length of 150 mm and a diameter of 0.35 mm. The sheath of the ligament support 6 is composed of a nanofiber membrane 5 prepared by electrospinning a mixed solution of silk fibroin and polycaprolactone, which is tightly wrapped and fixed on the outside of the suture 1 through twisting and twisting. The direction is Z twist, and the twist is about 90 twists / m. The initial shape of the electrospun nanofiber membrane 5 is a rectangle, the initial length is 80 mm, the initial width is 40 mm, and the initial thickness is 0.3 mm. The main body of the ligament support 6 is approximately cylindrical and has a diameter of 6 mm. Due to the twisting, the final main body len...

Embodiment 2

[0032] Figure 8 to Figure 14 A second embodiment of the invention is shown. in, Figure 8A ligament support 6 of the present embodiment is shown, which is used for a cruciate ligament support. The ligament support 6 is a core-sheath composite structure, in which the core is 2 USP7-OPDSII biodegradable sutures 1 with a length of 170 mm and a diameter of 0.07 mm bundled together. The sheath of the ligament support 6 is a nanofiber membrane 5 prepared by electrospinning a mixed solution of silk fibroin and caprolactone lactate copolymer P (LLA-CL), which is tightly wrapped and fixed by twisting and twisting. It is formed outside the suture 1, the twist direction is S twist, and the twist is about 80 twists / m. The wrapped electrospun nanofiber membrane 5 has an initial shape of a rectangle, an initial length of 100 mm, an initial width of 50 mm, and an initial thickness of 0.4 mm. The main body of the ligament support 6 is approximately cylindrical and has a diameter of 7 mm....

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Abstract

The invention provides a ligament bracket, a shaping method of the ligament bracket, and ligament implanting materials formed from the ligament bracket. The ligament bracket comprises a core part anda sheath part, wherein the core part is a threadlike or bunchy suture formed from biologic degradable high molecular polymers, the sheath part is formed through twirling and twisting biodegradable electrospun nanofiber membranes to closely wrap and be fixed outside the suture, and two ends of the suture extend from two ends of the sheath part to form a first traction line part and a second traction line part. According to the ligament bracket disclosed by the invention, by a twirling and twisting method, the electrospun nanofiber membranes closely wrap the outside of the suture, higher positive pressure is produced between fibers, tangential friction is enlarged, the ligament bracket has higher tensile violence in the axis direction, and besides, not less than two ligament brackets can bedoubled and twisted or knitted to form the ligament implanting materials having better tensile violence. Compared with the prior art, the ligament bracket can provide more effective mechanical supportto maintain stability of joints, and besides, quick scaleable preparation is facilitated.

Description

technical field [0001] The invention relates to the technical field of manufacturing medical tissue engineering brackets, in particular to a ligament bracket, a forming method thereof and a ligament implant formed therefrom. Background technique [0002] Ligaments are fibrous dense connective tissues that connect bone tissue, and play an important role in maintaining joint movement stability and normal physiological activities. Sports trauma, accidental injury, etc. often lead to damage or even rupture of the ligament. Due to the poor healing ability of the ligament itself, it is necessary to use graft reconstruction to restore its physiological function clinically. At present, the reconstruction and repair materials after ligament injury or rupture mainly include autografts, allografts and artificial ligaments. Among them, autografts cause damage to autologous tissues, resulting in complications at the donor site, and the source of donors is limited, and it is not clear wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/58D02G3/36D02G3/40D02G3/44D04H1/4382D04H1/728A61F2/08
CPCA61F2/08A61L27/26A61L27/58A61L2430/10D02G3/36D02G3/40D02G3/448D04H1/4382D04H1/728D10B2509/06C08L89/00C08L67/04
Inventor 裴泽光
Owner DONGHUA UNIV
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