Preparation method of high purity domestic fungus vitamin D2 extract

A preparation process and high-purity technology, applied in the production of bulk chemicals, organic chemistry, etc., can solve the problems of low efficiency and long time required, and achieve the effect of reducing by-products and improving conversion efficiency

Active Publication Date: 2019-08-23
浙江慧和健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the existing patent literature, direct irradiation treatment of slices or powder of fruiting bodies of edible mushrooms is generally carried out by ultraviolet rays, which takes a long time (generally several hours), while ergosterol is converted into VD 2 less efficient

Method used

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  • Preparation method of high purity domestic fungus vitamin D2 extract
  • Preparation method of high purity domestic fungus vitamin D2 extract
  • Preparation method of high purity domestic fungus vitamin D2 extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] S1: crush the dried fruiting bodies of Hericium erinaceus and sieve with 40 meshes.

[0037] S2: After sieving, dry under vacuum at 60° C. for 1 hour. The drying equipment adopts the German Binder binder VD23 vacuum drying oven.

[0038] S3: After drying for 1 hour, weigh 150g and put it into the extraction kettle. 2 extraction. The extraction equipment adopts the American Thar supercritical fluid ultrafine micro-granulation system SFP, the extraction pressure is set to 35MPa, the time is 3h, the temperature is 50°C, and the CO 2 The flow rate was 20 g / min.

[0039] S4: Collect the oily extract in the separation kettle.

[0040] S5: Carry out saponification treatment on the collected oily extract, the saponification temperature is 85° C., and the saponification time is 30 min.

[0041] S6: After saponification, extract with 150 mL of n-hexane for 3 times and combine the extracts.

[0042] S7: After the extraction of n-hexane, vacuum rotary evaporation was performe...

Embodiment 2

[0049] A high-purity edible mushroom vitamin D 2 The preparation technology of extract comprises the following steps:

[0050] S1: Crush the mushroom seeds and sieve them through a 30-mesh sieve.

[0051] S2: After sieving, dry under vacuum at 50° C. for 1 hour. The drying equipment adopts the German Binder binder VD23 vacuum drying oven.

[0052] S3: After drying for 1 hour, weigh 160g and put it into the extraction kettle. 2 extraction. The extraction equipment adopts the American Thar supercritical fluid ultra-fine granulation system SFP, the extraction pressure is set to 25MPa, the time is 1h, the temperature is 45°C, CO 2 The flow rate was 10 g / min.

[0053] S4: Collect the oily extract in the separation kettle.

[0054] S5: Perform saponification treatment on the collected oily extract, the saponification temperature is 70° C., and the saponification time is 20 minutes.

[0055] S6: After saponification, extract with 100 mL of n-hexane for 3 times and combine the ...

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Abstract

The invention discloses a preparation method of a high purity domestic fungus vitamin D2 extract. According to the preparation method, at early stage, supercritical extraction, saponification, and molecule distillation pre-treatment enrichment are adopted to obtain a domestic fungus ergosterol extract; then pulse high light short time irradiation treatment is adopted, full utilization of the energy of a plurality of ultraviolet rays and other wavelength light of pulse high light is adopted, rapid high efficiency conversion generation of VD2 is realized, and the high purity domestic fungus vitamin D2 extract is obtained. The preparation method is beneficial for development of related medical health care food, special medical food, or dietary supplement, and is capable of promoting value increasing of editable medicinal fungus resources.

Description

technical field [0001] The invention relates to the extraction and separation of ergosterol in edible fungi, and the conversion of high-purity natural vitamin D by pulsed strong light irradiation 2 The preparation process, specifically a high-purity edible fungus vitamin D 2 Extract preparation process. Background technique [0002] Vitamin D (vitamin D, VD) is a group of fat-soluble steroid derivatives, a total of five compounds, including vitamin D 2 (ergocalciferol) and vitamin D 3 (cholecalciferol) two active structures, of which VD 2 It cannot be synthesized in the human body, mainly through the intake of vegetables and dietary supplements. [0003] Vitamin D not only plays an important role in bone diseases (including nutritional rickets, rickets, osteoporosis, etc.). With the deepening of clinical research in recent years, VD also plays a very important role in non-skeletal diseases. Basic research has confirmed that vitamin D receptors (VDR) are widely distribu...

Claims

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Application Information

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IPC IPC(8): C07C401/00
CPCC07C401/00C07C2601/14C07C2602/24Y02P20/54
Inventor 杨开李坤叶帮伟
Owner 浙江慧和健康科技有限公司
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