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Thin-layer determination method for atropine sulfate and diphenhydramine hydrochloride in joint pain-relieving paste
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A technology of diphenhydramine hydrochloride and atropine sulfate, applied in measuring devices, instruments, scientific instruments, etc., can solve problems such as inability to obtain more accurate results
Inactive Publication Date: 2019-08-23
GUIZHOU LIANSHENG PHARMA
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[0004] The present invention aims at joint pain relief ointment as a combination of traditional Chinese medicine and western medicine. The coating of the samples is carried out at high temperature, and all the active substances are in the colloid. It is difficult to separate them by the existing thin-layer identification and determination method when analyzing the active ingredients of the medicine. The extraction of atropine sulfate and diphenhydramine hydrochloride leads to the inability to obtain more accurate results. A TLC method for the determination of atropine sulfate and diphenhydramine hydrochloride in joint pain relief ointment is provided
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Embodiment 1
[0047] The thin-layer determination method of atropine sulfate and diphenhydramine hydrochloride in joint pain ointment, including atropine sulfate thin-layer identification determination method and diphenhydramine hydrochloride thin-layer identification determination method. The thin-layer identification determination method for atropine sulfate includes the preparation of the control group reagent, the preparation of the test groupreagent and the thin-layer identification determination. The preparation of the control group reagent includes the following steps:
[0048] S1, take atropine sulfate and add a dissolving reagent to prepare a control reagent;
[0049] The preparation of reagents for the assay group includes the following steps:
[0050] S1, take the joint pain relief cream, place it in a flask, add reflux reagent, heat to reflux, let cool, filter, concentrate and cool to room temperature to prepare a concentrated liquid;
[0051] S2, take the concentrated liquid reagent, ...
Embodiment 2
[0067] The thin-layer determination method of atropine sulfate and diphenhydramine hydrochloride in joint pain ointment, including atropine sulfate thin-layer identification determination method and diphenhydramine hydrochloride thin-layer identification determination method. The thin-layer identification determination method for atropine sulfate includes the preparation of the control group reagent, the preparation of the test group reagent and the thin-layer identification determination. The preparation of the control group reagent includes the following steps:
[0068] S1: Take 2 mg of atropine sulfate and add 1 mL of absolute ethanol to prepare a control reagent;
[0069] The preparation of reagents for the assay group includes the following steps:
[0070] S1, take joint pain relief cream 280cm 2 , Cut into narrow strips, remove the lid liner, put in a 250ml flask, add 100ml of 0.1% sulfuric acid solution, heat to reflux for 1 hour, cool to room temperature, filter, and concentr...
Embodiment 3
[0087] In order to ensure the effect of the present invention, the applicant has carried out corresponding experimental research and demonstration on the identification method of atropine sulfate and diphenhydramine hydrochloride in the preparation, and the details are as follows:
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Abstract
The invention relates to the technical field of effective components of medicines, and in particular relates to a thin-layer determination method for atropinesulfate and diphenhydramine hydrochloridein a joint pain-relieving paste; the method comprises a thin-layer identification and measurement method of atropinesulfate and a thin-layer identification and measurement method of diphenhydraminehydrochloride. By aiming at the characteristics of all pharmaceutical ingredients in the joint pain-relieving paste, suitable extraction and preparation processes and needed preparations are providedbased on the thin-layer identification characteristics of atropinesulfate and diphenhydraminehydrochloride, so that components to be measured can be separated and extracted from a plurality of effective pharmaceutical ingredients of the joint pain-relieving paste to complete the thin-layer identification determination. The preparation method solves the problems that a relatively accurate resultcannot be obtained when atropine sulfate and diphenhydraminehydrochloride are singly extracted by the existing thin-layer identification and measurement method through medical effective ingredient analysis caused by the fact that sample coating in the traditional Chinese medicine and western medicine combination paste in the joint pain-relieving paste is all carried out at a high temperature, andall effective components are in colloid.
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