Unlock instant, AI-driven research and patent intelligence for your innovation.

Glabridin-multiple-coated solid preparation and preparation method thereof

A technology of glabridin and solid preparations, applied in skin care preparations, anti-toxins, pharmaceutical formulations, etc., can solve the problems of limiting the use of glabridin microcapsules, and achieve high yield, good water solubility, and high stability Effect

Pending Publication Date: 2019-08-27
佛山市康伲爱伦生物技术有限公司
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A method for preparing glabridin microcapsules by composite coacervation-spray drying method (application number 201410126307.6) discloses a method for preparing glabridin microcapsules by composite coacervation-spray drying method, because formaldehyde, a carcinogenic substance, is added for curing. And formaldehyde may remain, so greatly limited the application of this glabridin microcapsules in cosmetics

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glabridin-multiple-coated solid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A kind of preparation of glabridin multi-encapsulation solid preparation, its raw material is listed as follows according to weight ratio:

[0016] Glabridin 18.0%;

[0017] Hydroxypropyl-beta-cyclodextrin 20%;

[0018] Glycyrrhizic Acid 20%;

[0019] Glycyrrhiza polysaccharides added to 100%;

[0020] Other auxiliary ingredients are deionized water and absolute ethanol

[0021] The preparation steps are: step (1), dissolving glabridin in absolute ethanol, the ratio of glabridin to absolute ethanol is 1:10; step (2), dissolving cyclodextrin derivatives in anhydrous In ethanol, the ratio of cyclodextrin derivatives to absolute ethanol is 1:10; in step (3), the absolute ethanol formed by glabridin and cyclodextrin derivatives is dissolved, mixed and stirred for a certain period of time, then concentrated and dried to obtain Primary wrapping; step (4), dissolving licorice polysaccharide in deionized water, then adding glycyrrhizic acid in proportion, heating to 80°C, s...

Embodiment 2

[0023] A kind of preparation of glabridin multi-encapsulation solid preparation, its raw material is listed as follows according to weight ratio:

[0024] Glabridin 5.0%;

[0025] Hydroxypropyl-beta-cyclodextrin 20%;

[0026] Glycyrrhizic Acid 20%;

[0027] Glycyrrhiza polysaccharides added to 100%;

[0028] Other auxiliary ingredients are deionized water and absolute ethanol

[0029] The preparation steps are: step (1), dissolving glabridin in absolute ethanol, the ratio of glabridin to absolute ethanol is 1:10; step (2), dissolving cyclodextrin derivatives in anhydrous In ethanol, the ratio of cyclodextrin derivatives to absolute ethanol is 1:10; in step (3), the absolute ethanol formed by glabridin and cyclodextrin derivatives is dissolved, mixed and stirred for a certain period of time, then concentrated and dried to obtain Primary wrapping; step (4), dissolving licorice polysaccharide in deionized water, then adding glycyrrhizic acid in proportion, heating at 80°C, st...

Embodiment 3

[0031] A kind of preparation of glabridin multi-encapsulation solid preparation, its raw material is listed as follows according to weight ratio:

[0032] Glabridin 10.0%;

[0033] Hydroxypropyl-alpha-cyclodextrin 10%;

[0034] Glycyrrhizin 15%;

[0035] Glycyrrhiza polysaccharides added to 100%;

[0036] Other auxiliary ingredients are deionized water and absolute ethanol

[0037] The preparation steps are: step (1), dissolving glabridin in absolute ethanol, the ratio of glabridin to absolute ethanol is 1:10; step (2), dissolving cyclodextrin derivatives in anhydrous In ethanol, the ratio of cyclodextrin derivatives to absolute ethanol is 1:10; in step (3), the absolute ethanol formed by glabridin and cyclodextrin derivatives is dissolved, mixed and stirred for a certain period of time, then concentrated and dried to obtain Primary wrapping; step (4), dissolving licorice polysaccharide in deionized water, then adding glycyrrhizic acid in proportion, heating at 80°C, stirr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a glabridin-multiple-coated solid preparation and a preparation method thereof, and belongs to the field of medicine and cosmetics. The gabridin-multiple-coated solid preparation is prepared from the following components in percentage by weight: 0.5-20 percent of glabridin, 0.5-40 percent of a cyclodextrin derivative, 1-20 percent of glycyrrhiza polysaccharide, and 0.1-20 percent of glycyrrhizic acid. The preparation method of the glabridin-multiple-coated solid preparation involved in the invention comprises the following steps: dissolving an extract which is extractedfrom licorice root and contains the glabridin into an ethanol solution, adding certain proportion of the cyclodextrin derivative, heating and stirring until the dissolution is complete; concentratinguntil a solid just separates out, adding certain proportion of the glycyrrhiza polysaccharide and a glycyrrhizic acid water solution, and adding a small amount of ethanol until the solution clarifies; adjusting pH, heating and stirring, concentrating, and performing vacuum drying to obtain the glabridin-multiple-coated solid preparation. According to the glabridin-multiple-coated solid preparation and the preparation method thereof disclosed by the invention, the glabridin is subjected to multiple coating by fully using self active matters of cyclodextrin and the licorice root, the prepared glabridin solid preparation has the advantages of good water solubility, small safety risk, high stability, good slow release transdermal property and the like, the preparation process is simple, and the yield is high.

Description

technical field [0001] The invention belongs to the technical field of medicine and cosmetics, and relates to a preparation method of multi-encapsulation, in particular to a glabridin multi-encapsulation solid preparation and its preparation method. Background technique [0002] Glabridin is a kind of flavonoids in licorice, it shows a strong anti-free radical oxidation effect in the cytochrome P450 / NADPH oxidation system, can obviously inhibit the free radicals produced in the process of metabolism in the body, and has anti-tumor , anti-blood acid, lowering blood fat, anti-oxidation, anti-aging and other biological activities. In the field of cosmetics, glabridin has various effects such as whitening and freckle removal, and preventing skin aging. [0003] However, because glabridin is insoluble in water and is prone to change in light, high pH, ​​metal ions, high temperature and other environments, microencapsulation is of great significance to improve the water solubilit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/73A61K8/63A61K8/49A61Q19/02A61Q19/08A61K31/352A61K9/00A61K47/69A61K47/36A61K47/28A61P39/06A61P35/00A61P3/06A61P7/02
CPCA61K8/738A61K8/73A61K8/63A61K8/498A61Q19/02A61Q19/08A61K31/352A61K9/0014A61K47/6951A61K47/36A61K47/28A61P39/06A61P35/00A61P3/06A61P7/02
Inventor 杜志云王毅林丽朱林静韩萍李志威杜朋
Owner 佛山市康伲爱伦生物技术有限公司