Preparation method of water-soluble cannabidiol inclusion compound (nano capsule)

A technology of cannabidiol and nanocapsules, which is applied in the field of preparation of water-soluble cannabidiol inclusion compounds (nanocapsules), to achieve the effect of expanding the scope of use

Inactive Publication Date: 2019-08-30
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
View PDF5 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods only change the route of administration of cannabidi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Accurately weigh 100g of cannabidiol solid powder (purity above 99%) and 500g of ethanol into a 1L single-necked round bottom flask; place the flask in a water bath at 40°C and stir mechanically for 30 minutes to fully dissolve the cannabidiol solid; After the dissolution is complete, cool to room temperature for later use.

[0024] 2) Accurately weigh 300g of α-cyclodextrin and 900g of primary purified water into a 2L single-necked round bottom flask, place the flask in a 40°C water bath, and stir mechanically for 30 minutes to fully dissolve the α-cyclodextrin in the water. A transparent solution is formed; after the dissolution is complete, add the solution described in step (1) into it at one time, and continue stirring for 10 minutes.

[0025] 3) Preparation of clathrate: ultrasonic method

[0026] Transfer the mixed solution prepared in step 2) to an ultrasonic generator, seal the mouth of the bottle with a rubber stopper, and perform ultrasonic treatment for ...

Embodiment 2

[0029] 1) Accurately weigh 100g of cannabidiol solid powder (purity above 99%) and 500g of ethanol into a 1L single-necked round bottom flask; place the flask in a water bath at 40°C and stir mechanically for 30 minutes to fully dissolve the cannabidiol solid; After the dissolution is complete, cool to room temperature for later use.

[0030] 2) Accurately weigh 200g of α-cyclodextrin and 600g of primary purified water into a 2L single-necked round bottom flask, place the flask in a 40°C water bath, and stir mechanically for 30 minutes to fully dissolve the α-cyclodextrin in the water. A transparent solution is formed; after the dissolution is complete, add the solution described in step (1) into it at one time, and continue stirring for 10 minutes.

[0031] 3) Preparation of clathrate: stirring method

[0032] Put the mixed solution prepared in step 2) into a constant temperature water bath, stir with an electric mixer for 3 hours, set the speed at 300r / min, and set the temp...

Embodiment 3

[0035] 1) Accurately weigh 100g of cannabidiol solid powder (purity above 99%) and 300g of ethanol into a 1L single-necked round bottom flask; place the flask in a 55°C water bath, and stir mechanically for 30 minutes to fully dissolve the cannabidiol solid; After the dissolution is complete, cool to room temperature for later use.

[0036] 2) Accurately weigh 300g of α-cyclodextrin and 900g of primary purified water into a 2L single-necked round bottom flask, place the flask in a 40°C water bath, and stir mechanically for 30 minutes to fully dissolve the α-cyclodextrin in the water. A transparent solution is formed; after the dissolution is complete, add the solution described in step (1) into it at one time, and continue stirring for 10 minutes.

[0037] 3) Preparation of clathrate: high pressure homogenization method

[0038] Put the mixed liquid prepared in step 2) into a high-pressure homogenizer, start the high-pressure pump, and homogenize three times at a pressure of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a preparation method of a water-soluble cannabidiol inclusion compound (nano capsule). The method comprises the following steps: step 1, dissolving high-purity cannabidiol solid powder in ethanol to form a solution; step 2, dissolving cyclodextrin in pure water to form a solution; step 3, uniformly mixing the solutions formed in the step 1 and the step 2, carrying out cannabidiol inclusion by using any one of an ultrasonic method, a stirring method and a high-pressure homogenization method, and performing vacuum concentration by using a rotary evaporator after the inclusion so as to remove most of solvent and moisture; and step 4, drying the materials in the step 3 to obtain the cannabidiol inclusion compound (nano capsule). The method improves the solubility of the cannabidiol in water by thousands of times so as to thoroughly solve the problem of water solubility.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of a water-soluble cannabidiol inclusion compound (nanocapsule). Background technique [0002] Industrial hemp refers to cannabis with a tetrahydrocannabinol content of less than 0.3%. In my country, industrial hemp is called hemp, which is a 1-year-old herb of the genus Cannabis in the family Cannabinaceae. At present, there are more than 100 kinds of cannabinoids (CBs) isolated from the plant cannabis, mainly including tetrahydrocannabinol (tetrahydrocannabinol, THC), cannabidiol (cannabidiol, CBD) and cannabinol (cannabinol, CBN). and cannabichromene (CBC), among which THC and CBD have the highest content. Tetrahydrocannabinol (THC) has limited the development of its medicinal value due to its hallucinogenic and addictive properties. Cannabidiol is extracted from industrial hemp and is the main active ingredient in cannabinoids. Cann...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/60A61K47/69A23L2/38A23L2/52
CPCA23L2/38A23L2/52A61K36/60A61K47/6951
Inventor 刘胜贵王钲霖李智高付彬彬孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap