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A kind of preparation method of high-strength biomass tissue engineering scaffold material

A tissue engineering scaffold, biomass technology, applied in the direction of prosthesis, medical science, etc., can solve the problem of unachievable strength, and achieve the effect of increasing porosity, increasing strength, providing strength and resilience

Active Publication Date: 2021-07-13
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the strength of scaffold materials prepared by sodium alginate gel or chitosan gel cannot meet the requirements of practical applications.

Method used

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  • A kind of preparation method of high-strength biomass tissue engineering scaffold material

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Experimental program
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Effect test

Embodiment 1

[0041] A double network sodium alginate and chitosan-based multi-responsive high-strength biomass tissue engineering scaffold material with excellent biocompatibility of the present invention is prepared as follows:

[0042] (1) 20 o Under C, add 2.3g chitosan and 1.02g O-hydroxyethyl chitosan-grafted polylactic acid in 0.1mol / L acetic acid solution in 100ml concentration, obtain aqueous solution A after stirring for 5 hours;

[0043] (2) Add 40ml of sodium alginate aqueous solution B with a mass concentration of 2.5% to aqueous solution A, and stir evenly to form aqueous solution C;

[0044] (3) Continuously drop 11.5ml of 1g / mL sodium β-glycerophosphate aqueous solution into the aqueous solution C, stir well and form the prepolymer solution D;

[0045] (4) Raise the temperature of the pre-poly solution D to 38 o C and left for 30 minutes to form gel A;

[0046] (5) Rinse gel A repeatedly with water, and store it at -40 o Freeze and vacuum dry in C for 24 hours to obtain ...

Embodiment 2

[0060] A double network sodium alginate and chitosan-based multi-responsive high-strength biomass tissue engineering scaffold material with excellent biocompatibility of the present invention is prepared as follows:

[0061] (1) 20 o Under C, add 2.6g chitosan and 1.14g O-hydroxyethyl chitosan-grafted polylactic acid in 0.1mol / L acetic acid solution in 100ml concentration, obtain aqueous solution A through 6 hours stirring;

[0062] (2) Add 45ml of sodium alginate aqueous solution B with a mass concentration of 2.5% to aqueous solution A, and stir evenly to form aqueous solution C;

[0063] (3) Continuously drip 13.2ml of 1g / mL sodium β-glycerophosphate aqueous solution into the aqueous solution C, stir well and form the prepolymer solution D;

[0064] (4) Raise the temperature of the pre-poly solution D to 38 o C and left for 30 minutes to form gel A;

[0065] (5) Rinse gel A repeatedly with water, and store it at -40 o Freeze and vacuum dry in C for 24 hours to obtain 10...

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Abstract

The invention relates to a preparation method of sodium alginate and chitosan-based high-strength biomass group engineering scaffold material. The double-network gel constructed by the two-network is obtained after freeze-drying. The scaffold has excellent strength, resilience, large porosity, good biocompatibility and certain surface hydrophobicity, and can be used in the field of human tissue engineering.

Description

technical field [0001] The invention belongs to a preparation method of a biomass tissue engineering scaffold material, in particular to a preparation method of a biomass-based scaffold with high strength and good biocompatibility. Background technique [0002] Tissue engineering scaffold materials refer to materials that can be combined with living cells of tissues and implanted into different tissues of the organism, and replace the functions of the tissues according to specific conditions. In order to proliferate and differentiate seed cells, it is necessary to provide a cell scaffold composed of biomaterials, which is equivalent to artificial extracellular matrix. Tissue engineering scaffold materials include: tissue scaffold materials for bone, cartilage, blood vessels, nerves, skin and artificial organs, such as liver, spleen, kidney, bladder, etc. [0003] The current tissue engineering materials have various preparations and sources of raw materials, mainly includin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/56A61L27/58
CPCA61L27/20A61L27/56A61L27/58C08L5/08C08L5/04
Inventor 陈一卢嘉威
Owner HUNAN UNIV OF TECH