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Application of probiotic mixture Nagqu 4580 in foods to improve sleep quality

A technology for improving sleep quality and probiotics, applied in the field of microorganisms, can solve problems such as tolerance, residual effects, addiction, etc., and achieve the effect of improving sleep status, improving the effect, and shortening the time to fall asleep

Inactive Publication Date: 2019-09-06
河北一然生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of drugs can easily cause adverse reactions such as addiction, tolerance, and residual effects

Method used

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  • Application of probiotic mixture Nagqu 4580 in foods to improve sleep quality
  • Application of probiotic mixture Nagqu 4580 in foods to improve sleep quality
  • Application of probiotic mixture Nagqu 4580 in foods to improve sleep quality

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of Nagqu4580 probiotic mixed preparation:

[0019] a. Mixing: Add MRS medium into the chemical tank, then add sodium glutamate 10-30g / L, dissolve and stir for 10-15min, and keep the temperature of the feed liquid at 55-60°C;

[0020] b. Sterilization: After sterilizing the feed liquid, put it into the fermenter, pasteurize it at 105-115°C for 15-20 minutes;

[0021] c. Fermentation: Inoculate Nagqu4580 starter (provided by Hebei Yiran Biotechnology Co., Ltd.) into the feed liquid treated in step b for fermentation, the fermentation temperature is 37-45°C, and the fermentation temperature is 28-35h;

[0022] d. When the pH value of the fermentation is 4.4-4.6, stir in the fermentation tank;

[0023] e. Cryogenic granulation (dropping the liquid bacteria liquid into liquid nitrogen, and instantly cooling down to -193°C), freeze-drying (vacuum freeze-drying, freeze-drying temperature at -20~-70°C), to obtain Nagqu4580 probiotics Mixed preparations.

Embodiment 2

[0025] Improvement effect of Nagqu4580 probiotic mixture preparation on sleep quality. The test participants are required to take the mixed probiotic Nagqu 4580 (Nagqu 4580) of the present invention at a dosage of 0.5-2g / day.

[0026] The experiment is divided into 3 groups: 1) youth group (18-40 years old); 2) middle-aged group (41-59 years old); 3) elderly group (over 60 years old), taking 2 weeks, half an hour before going to bed to 1 Take it hours ago, the result is as follows Figure 1-3 and shown in Table 1-3.

[0027] Table 1 Results of Nagqu4580 Effective Rate of Revisited Subjects

[0028] crowd Efficient youth group 93％ Middle-aged group 87.5％ Old age group 100％

[0029] It can be seen from Table 1 that the effective rate of Nagqu4580 probiotic mixture preparation on improving sleep quality is above 93% on average.

[0030] Depend on Figure 1-3 It can be seen that the effective days for the youth group to feel that sleep is sig...

Embodiment 3

[0040] Embodiment 3 takes Nagqu4580 probiotic mixed preparation to improve sleep quality Pittsburgh Sleep Quality Index (PSQI) questionnaire statistical result

[0041] The Pittsburgh Sleep Quality Index (PSQI) reflects the sleep quality, sleep time, sleep time, sleep efficiency, sleep disorders, hypnotic drugs, daytime dysfunction and other indicators in the last month. Scoring scale: 0-5 points: good sleep quality; 5-10 points: fair sleep quality; 11-15 points: average sleep quality; 16-21 points: poor sleep quality. The result is as Figure 4 shown.

[0042] Depend on Figure 4 It can be seen that the PSQI index of the youth group decreased by 42.19% after taking it for one week, and 57.27% in the second week compared with before taking it; the PSQI index of the middle-aged group decreased by 32.96% after taking it for one week, The PSQI index decreased by 46.96% compared with before taking; the PSQI index of the elderly group decreased by 39.37% after taking for one wee...

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Abstract

The invention belongs to the technical field of microorganisms and relates to application of probiotic mixture Nagqu 4580 in foods to improve sleep quality. After taking Nagqu 4580 for two weeks, thesleep conditions of people of different agents are evidently improved; with the time of taking Nagqu 4580 getting longer, the improvement effect is better; the improvement rate is 93% and above; administration days focus to 3-4 days; in terms of symptom improvement, sleep latency is shorter, sleep time is extended, and the symptoms can be improved, such as waking up at midnight.

Description

technical field [0001] The invention belongs to the technical field of microbes, and relates to the application of mixed probiotic Nagqu 4580 (Nagqu 4580) in food for improving sleep quality. The mixed probiotic Nagqu 4580 (Nagqu 4580) has good acid resistance and can grow well under the environmental conditions of PH3.0; it can produce high content of GABA, 5-HT, acetic acid, malic acid, citric acid and Tartaric acid has obvious effects on sleep and anti-fatigue. Background technique [0002] Sleep is an important part of people's daily life. With the acceleration of the pace of social life, various social pressures such as buying a house and employment, various forms of sleep quality problems such as sleep disorders and insomnia have also gradually emerged among the crowd. The tendency to spread. [0003] Poor sleep quality is a risk factor for many diseases, and is closely related to high blood pressure, coronary heart disease, diabetes, etc. At the same time, it can al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135
CPCA23L33/135A23V2002/00A23V2400/147A23V2400/165A23V2400/249A23V2200/322
Inventor 赵林森杨玲孙策李玲贾洪利仵红岩
Owner 河北一然生物科技股份有限公司
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