High-throughput microfluidic chip and method for sorting cancer cells
A microfluidic chip and high-throughput technology, applied in cell dissociation methods, tumor/cancer cell, tissue cell/virus culture devices, etc., can solve problems such as false positives, unreliable data, and low efficiency, and achieve High screening accuracy, short screening cycle and high efficiency
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Embodiment 1
[0042] A high-throughput microfluidic chip and a method for screening white blood cells.
[0043] The high-throughput microfluidic chip has such figure 1 The structure shown includes a sample injection channel 1, a buffer solution inlet channel 2, a main channel 3, a first liquid outlet channel 4, and a second liquid outlet channel 5, and the main channel 3 includes an arc-shaped channel with a gradually increasing radius of curvature 31 and the straight channel 32, the arc channel 31 and the straight channel 32 communicate with each other, and naturally transition; wherein, the angle α=30° between the sample injection channel 1 and the tangent line of the arc channel 31, the width is 150 μm, and the height is 196 μm; the buffer solution The angle between the liquid inlet channel 2 and the tangent line of the arc channel 31 is β=90°, the width is 850 μm, and the height is 196 μm; the width of the main channel 3 is 1000 μm, the height is 196 μm, and the arc starting from the en...
Embodiment 2
[0049] A high-throughput microfluidic chip and its method for screening microbeads (the microbeads involved in the method are particles with a particle size of about 10 μm, which are used to simulate white blood cells).
[0050] The high-throughput microfluidic chip has such figure 1 The structure shown includes a sample injection channel 1, a buffer solution inlet channel 2, a main channel 3, a first liquid outlet channel 4, and a second liquid outlet channel 5, and the main channel 3 includes an arc-shaped channel with a gradually increasing radius of curvature 31 and the straight channel 32, the arc channel 31 and the straight channel 32 communicate with each other, and naturally transition; wherein, the angle α=45° between the sample injection channel 1 and the tangent line of the arc channel 31, the width is 150 μm, and the height is 190 μm; the buffer solution The angle β=90° between the inlet channel 2 and the tangent line of the arc channel 31, the width is 850 μm, and...
Embodiment 3
[0056] A high-throughput microfluidic chip and its method for screening cancer cells.
[0057] The high-throughput microfluidic chip has such figure 1The structure shown includes a sample injection channel 1, a buffer solution inlet channel 2, a main channel 3, a first liquid outlet channel 4, and a second liquid outlet channel 5, and the main channel 3 includes an arc-shaped channel with a gradually increasing radius of curvature 31 and the straight channel 32, the arc channel 31 and the straight channel 32 communicate with each other, and naturally transition; wherein, the angle α=30° between the sample injection channel 1 and the tangent line of the arc channel 31, the width is 150 μm, and the height is 192 μm; the buffer solution The angle between the liquid inlet channel 2 and the tangent line of the arc channel 31 is β=90°, the width is 850 μm, and the height is 192 μm; the width of the main channel 3 is 1000 μm, the height is 192 μm, and the arc starting from the end of...
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