The invention discloses a blocked type variable cross-section reciprocating squeezing, twisting and upsetting forming method for ultra-fine grain bars. On the basis of a three-way hydraulic forming machine, the die assembly force is provided through an upper slide block, and pressure required for forming of punches at the two ends is provided through a left slide block and a right slide block. A die inner cavity is a linear channel formed by sequentially connecting a first squeezing channel, a middle twisting channel and a second squeezing channel on the same straight line. The section area of the middle twisting channel is smaller than the section area of the first squeezing channel and the section area of the second squeezing channel. The punches at the two ends are located at the two ends of the linear channel in a one-to-one correspondence manner, and a blocked variable section cavity is formed through the reciprocating punches at the two ends. By means of reciprocating of the punches at the two ends, the reciprocating squeezing, twisting and upsetting process of a to-be-processed blank in the linear channel is achieved, and preparation of the ultra-fine grain bars is completed through multi-pass forming. By means of the blocked type variable cross-section reciprocating squeezing, twisting and upsetting forming method, bar grains can be effectively refined, the forming limit of the bars is improved, and the blocked type variable cross-section reciprocating squeezing, twisting and upsetting forming method is easy to operate, high in applicability and capable of being easily applied in an engineered manner.