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Proton intelligent online monitoring system and method

A monitoring system and proton technology, applied in the field of proton range and dose online monitoring, can solve the problem of not giving a solution to the uncertainty of proton range, achieve good noise immunity, reduce the requirements of spatial resolution, reduce number and effect

Active Publication Date: 2019-09-10
彭浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

No solution given for proton range uncertainty

Method used

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  • Proton intelligent online monitoring system and method
  • Proton intelligent online monitoring system and method
  • Proton intelligent online monitoring system and method

Examples

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Embodiment 1

[0048] Such as figure 1 As shown in , a beam monitoring device (8), namely BTD (Beam tagging device), is provided in front of the treatment head 7, and the treatment head 7 emits a proton beam to the patient located in the treatment cabin 6 (coach). The proton intelligent online monitoring system of the present invention includes a plurality of gamma ray detector units (1) arranged along the beam path;

[0049] A grating 2 is arranged upstream of the gamma-ray detector unit 1 . With this structure, accurate monitoring of transient photons (PG) and positron-electron annihilation photons (PEAG) is realized.

[0050] Such as figure 1 As shown, the proton beam passes through the beam monitoring device (8) (Beamtagging device) after it emerges from the treatment head 7 (Nozzle). This device can not only monitor the position and flux of the proton beam, but also serve as a time signal Starting point T1. After the proton beam is injected into the human body, a series of reactions...

Embodiment 2

[0074] A kind of monitoring method that adopts the proton intelligent online monitoring system described in embodiment 1, comprises the following steps:

[0075] s1. Multiple gamma-ray detectors are placed along the beam transmission path to monitor two types of gamma photons produced by nuclear reactions in proton therapy: including PEAG and PG;

[0076] s2. Input the phase space information of the detected gamma photons, including space information, energy information and time evolution information, into the feed-forward neural network trained by a large sample database for machine learning, so as to reconstruct the range of the proton.

[0077] In the preferred scheme, the following steps are also included:

[0078] s3. Use the spatial dose convolution filtering method to perform anisotropic Gaussian broadening on the dose of each voxel point in the original plan to obtain the actual dose distribution.

[0079] Such as Image 6 As shown in , by adopting the spatial dose c...

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Abstract

The invention provides a proton intelligent online monitoring system and a method. The system includes a plurality of gamma ray detector units arranged along a beam path; and gratings are disposed infront of the gamma ray detector units. The gamma ray detector units include an array of scintillation crystals and one-to-one corresponding array of photomultiplier tubes. Two types of [gamma] photonsgenerated due to nuclear reactions in proton therapy are detected by placing sparsely distributed gamma ray detectors on a beam transport path: one is produced by positron nuclides [beta]+decay annihilation, and the other is generated by de-excitation of a nucleus in an excited state. Then phase space information of detected [gamma] photons is input to a feedforward neural network trained by a large sample database for performing machine learning to reconstruct a range of protons. Actual dosage distribution is obtained by utilizing a spatial dosage convolution filtering method, and accurate monitoring of proton beam ranges and dosages are finally achieved.

Description

technical field [0001] The invention relates to the field of on-line proton range and dose monitoring, in particular to a proton intelligent on-line monitoring system and method. Background technique [0002] The goal of ideal tumor radiation therapy is to deliver the maximum lethal dose to the tumor volume while minimizing the radiation dose to surrounding normal organs. Compared with traditional X-ray therapy, the proton beam has a unique dosimetric characteristic, the Bragg peak. This greatly reduces the energy deposition of the proton beam before reaching the tumor tissue, and the energy deposition after the Bragg peak drops rapidly, so that the irradiation dose of the normal tissue around the tumor tissue is greatly reduced. Therefore, proton beams can deliver higher irradiation doses to tumor tissues while better protecting normal organs. [0003] The Bragg peak is the physical advantage of proton beam therapy, but it also brings a huge challenge to the clinical appl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
CPCA61N5/1031A61N5/1071A61N5/1064A61N2005/1034A61N2005/1087
Inventor 彭浩代智涛
Owner 彭浩
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