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Material for promoting repairing of defect and deficiency tissue of teeth and preparation method of material

A technology for tissue repair and tooth application in dental preparations, dentistry, pharmaceutical formulations, etc., which can solve problems such as slow restoration, cracks at the interface between teeth and materials, and poor mechanical properties, so as to promote tooth tissue restoration. The preparation method is simple, The effect of low equipment requirements

Inactive Publication Date: 2019-09-17
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As time goes by, the mechanical properties of the restorative material are poor after restoration, and cracks will appear at the interface between the tooth and the material, which will cause secondary caries and even the restoration material will fall off
A Chinese invention patent for the preparation of a demineralization-resistant enamel repair material (application number: 201810568053.1 application date: 2018-06-05), the prepared material is mainly aimed at the poor mechanical properties of the enamel repair material after restoration, and fix slowness

Method used

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  • Material for promoting repairing of defect and deficiency tissue of teeth and preparation method of material
  • Material for promoting repairing of defect and deficiency tissue of teeth and preparation method of material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Dissolve 0.05g of polyacrylic acid in 500g of distilled water to make a polyacrylic acid solution with a concentration of 0.1g / L;

[0032] 2) Dissolving 0.1 g of sodium β-phosphoglycerate in the polyacrylic acid solution of step 1) to obtain a mixed solution of 0.2 g / L sodium β-phosphoglycerate;

[0033] 3) Dissolve 0.2 g of potassium dihydrogen phosphate in the solution of step 2) to obtain a 0.4 g / L potassium dihydrogen phosphate mixed solution;

[0034] 4) Dissolving 0.01 g of enamel matrix protein in the solution of step 3) to obtain 0.02 g / L enamel matrix protein mixed solution 1;

[0035] 5) 0.2g of calcium chloride was dissolved in 500g of distilled water to obtain 0.4g / L of calcium chloride mixed solution II;

[0036] 6) Filter the mixed solution 1 of step 4) and the mixed solution 2 of step 5) respectively with a filter of 0.45 μm;

[0037] 7) Mixing equal volumes of the two solutions filtered in step 6) to obtain the material.

[0038] Gained material is...

Embodiment 2

[0041] 1) Dissolve 0.04g of polyacrylic acid in 500g of distilled water to make a polyacrylic acid solution with a concentration of 0.08g / L;

[0042] 2) Dissolving 0.4 g of sodium β-phosphoglycerate in the polyacrylic acid solution of step 1) to obtain a mixed solution of 0.8 g / L sodium β-phosphoglycerate;

[0043] 3) Dissolving 0.3 g of potassium dihydrogen phosphate in the solution of step 2) to obtain 0.06 g / L of enamel matrix protein mixed solution 1;

[0044] 4) Dissolving 0.02 g of enamel matrix protein in the solution of step 3) to obtain 0.04 g / L of enamel matrix protein mixed solution 1;

[0045] 5) Dissolve 0.3g calcium chloride in 500g distilled water to obtain 0.6g / L calcium chloride mixed solution II;

[0046] 6) Filter the mixed solution 1 of step 4) and the mixed solution 2 of step 5) respectively with a filter of 0.45 μm;

[0047] 7) Mixing equal volumes of the two solutions filtered in step 6) to obtain the material.

[0048] Gained material is tested, test...

Embodiment 3

[0051] 1) Dissolve 0.06g of polyacrylic acid in 500g of distilled water to make a polyacrylic acid solution with a concentration of 0.12g / L;

[0052] 2) Dissolving 0.54 g of sodium β-phosphoglycerate in the polyacrylic acid solution of step 1) to obtain a mixed solution of 1.08 g / L of sodium β-phosphoglycerate;

[0053] 3) Dissolving 0.5 g of potassium dihydrogen phosphate in the solution of step 2) to obtain a 1.0 g / L potassium dihydrogen phosphate mixed solution;

[0054] 4) Dissolving 0.04 g of enamel matrix protein in the solution of step 3) to obtain 0.08 g / L of enamel matrix protein mixed solution 1;

[0055] 5) the calcium chloride of 0.4g is dissolved in 500g distilled water, obtains the calcium chloride mixed solution 2 of 0.8g / L;

[0056] 6) Filter the mixed solution 1 of step 4) and the mixed solution 2 of step 5) respectively with a filter of 0.45 μm;

[0057] 7) Mixing equal volumes of the two solutions filtered in step 6) to obtain the material.

[0058] Gaine...

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Abstract

The invention discloses a material for promoting repairing of the defect and deficiency tissue of teeth and a preparation method. The material is gel and comprises 0.2-0.5 g of calcium chloride, 0.2-0.8 g of mono potassium phosphate, 0.04-0.1 g of polyacrylic acid, 0.01-0.05 g of dental enamel matrix protein, 0.1-1.0 g of beta-phosphoric acid sodium glycerinate and 1000 g of distilled water. The preparation method of the material is easy to implement and low in cost and requirement for equipment. The defect and deficiency parts of the teeth are filled with the material, which can promote repairing of the tooth tissue, main components of a repairing layer are hydroxyapatite crystals, the composition of the repairing layer is basically identical to that of dental enamel, and the interface between the filling material and natural teeth is eliminated; the tooth cavities with the depth of 1 millimeter are filled with the material, and after seven days, the highest thickness of the repairing layer can reach 0.63 millimeter.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a material for promoting the restoration of tooth defect and missing tissue and a preparation method thereof. Background technique [0002] Restoration of tooth defects is currently performed with filling restoration materials, such as composite resin, silver amalgam, glass ionomer, etc. The nature of the composition of this type of restorative material is different from that of natural tooth tissue, and there is an interface between the restored material and the natural tooth. As time goes by, the mechanical properties of the restorative material are poor after restoration, and cracks will appear at the interface between the tooth and the material, which will cause secondary caries and even the loss of the restorative material. A Chinese invention patent for the preparation of a demineralization-resistant enamel repair material (application number: 201810568053.1 a...

Claims

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Application Information

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IPC IPC(8): A61K6/00A61K6/027A61K6/033A61K6/083A61K6/838
CPCA61K6/00A61K6/831A61K6/838A61K6/887
Inventor 李志安陈智
Owner WUHAN UNIV
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