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Method for synthesizing antibacterial hydrogel capable of hydrolyzing under weak alkaline condition

A synthesis method and a hydrogel technology are applied in the synthesis field of antibacterial hydrogels, which can solve the problems of poor biodegradability, use a large amount of solvents, cumbersome preparation methods, etc., and achieve high yield, simple process and good sterilization effect. Effect

Active Publication Date: 2019-09-27
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Quaternary ammonium salts are generally introduced through the quaternization reaction of tertiary amines and halogenated alkanes or halogens and tertiary amines. Tertiary amines interact with halogen atoms to form ionic structures. However, many quaternary ammonium salts antibacterial hydrogels currently have cumbersome preparation methods. , poor biodegradability, and the use of a large amount of solvents, etc., still need in-depth research

Method used

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  • Method for synthesizing antibacterial hydrogel capable of hydrolyzing under weak alkaline condition
  • Method for synthesizing antibacterial hydrogel capable of hydrolyzing under weak alkaline condition
  • Method for synthesizing antibacterial hydrogel capable of hydrolyzing under weak alkaline condition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Octavinyl POSS (0.63 g, 1 mmol) and 3-(dimethylamino)-1-propanethiol (DPT) (1.19 g, 10 mmol), followed by dry THF (5 mL) were added to a 25 mL flask. The flask was wrapped with aluminum foil, and then the photoinitiator DMPA (41 mg, 0.16 mmol) was added thereto. After sealing, use high-purity N 2 The mixture is purged to remove oxygen. Then, the aluminum foil was removed and the reaction was triggered under UV irradiation at 365 nm at room temperature. As the reaction progressed, the octavinyl POSS gradually dissolved in the solution. After 1 hour, turn off the UV light. Excess 3-(dimethylamino)-1-propanethiol was removed by vacuum evaporation at 30°C. A viscous liquid was obtained with a yield of 87.45%.

[0023] Gained 1mmol compound that contains eight tertiary amines, 1mmol hexanediol chloroacetate, 6mmol hexadecyl alcohol chloroacetate are directly mixed, reacted for a period of time and then injected into the membrane tool to obtain quaternary ammonium salt a...

Embodiment 2

[0027] Octavinyl POSS (0.63 g, 1 mmol) and 3-(dimethylamino)-1-propanethiol (DPT) (1.19 g, 10 mmol), followed by dry THF (5 mL) were added to a 25 mL flask. The flask was wrapped with aluminum foil, and then the photoinitiator DMPA (41 mg, 0.16 mmol) was added thereto. After sealing, use high-purity N 2 The mixture is purged to remove oxygen. Then, the aluminum foil was removed and the reaction was triggered under UV irradiation at 365 nm at room temperature. As the reaction progressed, the octavinyl POSS gradually dissolved in the solution. After 1 hour, turn off the UV light. Excess 3-(dimethylamino)-1-propanethiol was removed by vacuum evaporation at 30°C. A viscous liquid was obtained with a yield of 87.45%.

[0028] Gained 1mmol compound that contains eight tertiary amines, 1mmol hexanediol chloroacetate, 6mmol tetradecyl chloroacetate are directly mixed, reacted for a period of time and then injected into the membrane tool to obtain quaternary ammonium salt and Gel...

Embodiment 3

[0030] Octavinyl POSS (0.63 g, 1 mmol) and 3-(dimethylamino)-1-propanethiol (DPT) (1.19 g, 10 mmol), followed by dry THF (5 mL) were added to a 25 mL flask. The flask was wrapped with aluminum foil, and then the photoinitiator DMPA (41 mg, 0.16 mmol) was added thereto. After sealing, use high-purity N 2 The mixture is purged to remove oxygen. Then, the aluminum foil was removed and the reaction was triggered under UV irradiation at 365 nm at room temperature. As the reaction progressed, the octavinyl POSS gradually dissolved in the solution. After 1 hour, turn off the UV light. Excess 3-(dimethylamino)-1-propanethiol was removed by vacuum evaporation at 30°C. A viscous liquid was obtained with a yield of 87.45%.

[0031] Gained 1mmol compound containing eight tertiary amines, 1mmol hexanediol chloroacetate, 6mmol dodecyl alcohol chloroacetate are directly mixed, reacted for a period of time and then injected into the membrane tool, to obtain quaternary ammonium salt and ...

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Abstract

The invention discloses a method for synthesizing an antibacterial hydrogel capable of hydrolyzing under a weak alkaline condition. The method comprises the following steps: sequentially adding octavinyloctasilasesquioxane, a tertiary amine thiol and dry tetrahydrofuran into a reactor, packaging the reactor with an aluminum foil, adding a photoinitiator, sealing the reactor, purging the obtained mixture with high-purity N2 to remove oxygen, removing the aluminum foil, and performing room-temperature stirring ad reacting under the irradiation of 365 nm ultraviolet rays for 1-12 h; carrying out rotary evaporation after the completion of the reaction in order to remove the solvent and the excess tertiary amine thiol in order to obtain a viscous liquid; and taking the viscous liquid, uniformly mixing the viscous liquid with dihalogenated hydrocarbon ester and a monohalogenated hydrocarbon ester at room temperature, carrying out a reaction for a period of time, adding the obtained reacted mixture into a mold to obtain a cured gel, and immersing the cured gel in ultrapure water for sufficient swelling in order to obtain the product. The hydrogel obtained in the invention has the advantages of short gel forming time, simple preparation process, hydrolyzing under the weak alkaline condition, and excellent antibacterial effect, and can be applied in the fields of biological dressings and the like.

Description

technical field [0001] The invention relates to a synthesis method of an antibacterial hydrogel that can be hydrolyzed under weak alkalinity, specifically a silicon oxide hydrogel that contains quaternary ammonium salts, long-chain alkyl antibacterial groups, and can be hydrolyzed under weak alkalinity. bonded and ester bonded gel polymers. Background technique [0002] Antibacterial hydrogel is an important antibacterial material, which has important applications in medical dressings, medical device coatings, and tissue engineering. At present, common antibacterial polymers include quaternary ammonium salt polymers, quaternary phosphonium salt polymers, haloamine polymers, guanidine polymers, and the like. An ideal antibacterial hydrogel material should have high antibacterial activity, good biocompatibility, good biodegradability, simple and mild preparation method and low cost. However, such hydrogels with various properties are rarely reported so far. Therefore, it is...

Claims

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Application Information

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IPC IPC(8): C08G77/392C08G77/388
CPCC08G77/388C08G77/392
Inventor 韩金陈钦越沈宇鹏马佳奇冯祎平钟明强
Owner ZHEJIANG UNIV OF TECH