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Ion Separation and Detection Method Based on Quadrupole Linear Ion Trap Tandem Mass Spectrometer

A linear ion trap and tandem mass spectrometry technology, which is applied in the field of efficient selective reaction monitoring of target substances, can solve the problems of difficult popularization, failure to achieve results, and little effect, and achieve the effect of efficient detection

Active Publication Date: 2021-10-29
NAT INST OF METROLOGY CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Of course, to address this problem, increasing the ion capacity of LIT (it is difficult to increase by more than 20 times) is a possible solution through multiple ion implantation, but the complexity and difficulty of implementation are too great and the results are minimal.
Therefore, even if the instrument of Q-LIT (or QTrap) appears on the market, it does not achieve the desired effect, and its application is difficult to popularize.

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  • Ion Separation and Detection Method Based on Quadrupole Linear Ion Trap Tandem Mass Spectrometer
  • Ion Separation and Detection Method Based on Quadrupole Linear Ion Trap Tandem Mass Spectrometer
  • Ion Separation and Detection Method Based on Quadrupole Linear Ion Trap Tandem Mass Spectrometer

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Embodiment Construction

[0037] Attached below Figure 1-3And the following specific examples describe the method of the present invention in detail.

[0038] Such as figure 1 The shown quadrupole linear ion trap tandem mass spectrometer mass spectrometry device includes an ion source 101, an ion guidance system (including an ion introduction pipeline 111 and an ion guidance pipeline 112), a pre-quadrupole 121, and a filter quadrupole Rod 122 , rear quadrupole rod 123 , linear ion trap 131 , multi-stage gradient vacuum system 110 , detector 151 for detecting ions, and buffer gas injection system 161 for injecting buffer gas into linear ion trap 131 through gas conduit 141 .

[0039] The multi-stage gradient vacuum system 110 includes a plurality of vacuum intervals in which the air pressure decreases sequentially, and each vacuum interval has a through hole. The ion introduction system includes an ion introduction pipeline 111 communicated with the ion source 101 and an Ion guide lines 112 in each v...

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Abstract

A method for ion separation and detection based on a quadrupole linear ion trap tandem mass spectrometer, is to use a quadrupole to screen out sample ions of interest (monitored ions), inject the monitored ions into a linear ion trap (131), etc. The monitored ions enter the linear ion trap (131), using edge collisions to induce dissociation of the monitored ions, and edge isolation to retain the fragmented product ions of the monitored ions (characteristic ions of the monitored ions). Such a long-term operation series can Efficiently enrich the fragmented product ions of the monitored ions, so as to realize the efficient detection of the monitored ions. This method is especially suitable for the qualitative and quantitative analysis of trace substances (objects of interest) in complex matrices.

Description

technical field [0001] The invention relates to a qualitative and quantitative operation method for target substances based on a quadrupole linear ion trap tandem mass spectrometer, in particular to an operation method for efficient selective reaction monitoring of target substances. Background technique [0002] The method of mass spectrometry is to ionize material particles (atoms, molecules) into ions, and separate them according to their spatial position and time sequence through an appropriate stable or changing electric field or magnetic field to achieve mass-to-charge ratio separation, and detect their intensity for qualitative, Analytical methods for quantitative analysis. Because the mass spectrometry method directly measures the material particles, and has the characteristics of high sensitivity, high resolution, high throughput and high applicability, mass spectrometry plays an important role in modern science and technology. With the development of life science,...

Claims

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Application Information

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IPC IPC(8): H01J49/42G01N27/62
CPCH01J49/42G01N27/623
Inventor 熊行创方向江游黄泽建龚晓云
Owner NAT INST OF METROLOGY CHINA